Aromatic C–H Functionalization

Metal‐, Oxidant‐, and Additive‐Free Sulfenylation of Imidazo[1,2‐a]pyridines Using Sulfenamides and an I2 Catalyst

“…To our great excitement, the target product 3 aa was obtained at 19% yield after reacting at 80 °C for 4.5 h with 1,2-dichloroethane (1,2-DCE) as the solvent (Table 1, entry 1). After consulting the literature, [10][11][12][13][14][15][16][17][18]22] we found that many reaction systems for constructing CÀ S bonds could be significantly improved by using iodides as catalysts. Therefore, a series of iodides were examined.…”

“…[19] Our research group is interested in developing green and sustainable methods for the synthesis of sulfides [20] and functionalizing the CÀ H bond of heterocyclic compounds. [21] Inspired by the recent works on sulfenamides and iodine-catalyzed reactions, [19,22] here we propose a method to synthesize imidazo[1,2-a]pyridyl sulfides using sulfenamides as the sulfenylation reagent without any oxidants or additives (Scheme 2b).…”

Oxidative hydrolysis of aliphatic bromoalkenes: scope study and reactivity insights

“…Enter hypervalent iodine reagents -a leading metal-free choice for oxidation reactions. These robust and low-toxicity reagents have gained popularity due to their commercial availability [1][2][3][4][5] and versatility for phenolic dearomatizations, oxidative annulations, fragmentations, and oxidative rearrangements [6][7][8][9][10][11]. In particular, iodine(III) reagents have been proven effective for a wide range of oxidative transformations, cementing their position as a go-to option for organic chemists.…”