Aronia melanocarpa Elliot anthocyanins inhibit colon cancer by regulating glutamine metabolism

Wang, Yu; Gao, Jun; Hao, Ruobing; Zhang, Chenjuan; Liu, Hongwei; Fan, Jie; Wei, Jie

doi:10.1016/j.fbio.2021.100910

Cited by 17 publications

(8 citation statements)

References 33 publications

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“…Yu et al analyzed the oncostatic e cacy of Aronia melanocarpa Elliot anthocyanins (AMA) against colon cancer in vivo (C57BL/6 mice model) and in vitro (Caco-2 colon cancer cell line). AMA signi cantly inhibited the proliferation of Caco-2 cells, suppressed cancer-related in ammation (decreased level of in ammatory cytokines), and reduced glutaminase and SLC1A5 (Yu et al 2021). Table 3 and Fig.…”

Section: Flavonoids and Redox Balance Mediated By Nrf2mentioning

confidence: 99%

Flavonoids Attentuate Cancer Metabolism by Modulating Redox State, lipid metabolism, and use of amino acids or ketone bodies

Samec

Mazuráková

Lucansky

et al. 2022

Preprint

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Metabolic reprogramming of cancer cells is a common hallmark of malignant transformation. Cancer cells rewire metabolism to meet increased nutritional requirements necessary for enhanced cellular proliferation and growth. The preference for aerobic glycolysis over oxidative phosphorylation in tumors is a well-studied phenomenon known as the Warburg effect. Importantly, metabolic transformation also involves an alteration in signaling cascades contributing to lipid metabolism, amino acid flux and synthesis, redox balance, and utilization of ketone bodies as an alternative fuel promoting carcinogenesis. Flavonoids, widely distributed phytochemicals in plants, exert various beneficial effects on human health through modulating molecular cascades altered in the pathological phenotype. Recent evidence has identified numerous flavonoids and their derivates as modulators of critical components of cancer metabolism. Flavonoids affect lipid metabolism by regulating fatty acid synthase (FAS) or transcription activity of sterol regulatory element-binding protein 1/2 (SREBP1/2), redox balance by modulating nuclear factor-erythroid factor 2-related factor 2 (Nrf2) activity, amino acid flux and synthesis by phosphoglycerate mutase 1 (PGAM1), or ketone bodies generation mediated by 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) in stromal cells to supplement energetic demands of epithelial cancer cells. Here, we discuss recent preclinical evidence evaluating the impact of flavonoids on cancer metabolism, focusing on lipid and amino acid metabolic cascades, redox balance, and ketone bodies. Flavonoids, which affect metabolic pathways of cancer cells by targeting critical enzymes and transporters, represent a promising avenue to accelerate cancer-related research; however, more in-depth investigation is essential to implement innovative and progressive therapeutic approaches in cancer management.

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Section: Flavonoids and Redox Balance Mediated By Nrf2mentioning

confidence: 99%

Flavonoids Attentuate Cancer Metabolism by Modulating Redox State, lipid metabolism, and use of amino acids or ketone bodies

Samec

Mazuráková

Lucansky

et al. 2022

Preprint

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“…It was discovered that this treatment inhibited Caco-2 cell proliferation and viability compared to untreated cells [13]. Aronia melanocarpa Elliot anthocyanins also showed anti-cancer activity by inhibiting Caco-2 cell proliferation, and the IC50 value was reported to be 148.3 μg/ml [29]. Based on in vitro and in vivo investigations, it is hypothesized that the majority of chokeberry extracts' anti-cancer properties result from the antioxidative activity of polyphenolics, particularly anthocyanins and chlorogenic acids.…”

Section: Effects Of Aronia Extract On Htert Concentrationsmentioning

confidence: 99%

“…SLC1A5 is a cancer-specific amino acid carrier that regulates cell proliferation and invasion. Targeting SLC1A5 may lead to identifying new anti-cancer drugs derived from Aronia berries [34]. Furthermore, it was discovered that the anthocyanins found in Aronia berries inhibit Caco-2 cell development via the Wnt/-catenin signaling pathway.…”

Section: Effects Of Aronia Extract On Htert Concentrationsmentioning

confidence: 99%

A preliminary study of the anti-proliferative effect of Aronia Melanocarpa extract on human colon cancer cells and its relation with human TERT protein

Caliskan¹,

Yucel²,

Celikok³

et al. 2023

j-ebr

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Aronia melanocarpa is a fruit exhibiting antioxidant, anti-inflammatory, antidiabetic, hypolipidemic, and anticarcinogenic properties. Telomerase is a critical factor in the development of colon cancer, and it is being looked at as a target for cancer treatments. In the present study, we aimed to examine the potential effect of Aronia melanocarpa extract on cell viability and protein concentration of the human telomerase reverse transcriptase (hTERT) in the human colon cancer cell line (HT-29) and the non-tumorigenic human umbilical vein endothelial cell line (HUVEC). Methods: Cell lines were treated with different concentrations of Aronia extract (50-750 μg/ml) for 48 h. The cytotoxic activity of Aronia extract was determined using the MTT assay. hTERT protein concentration (pg/ml) was measured using a sandwich ELISA. Results: The MTT assay test showed that Aronia extract induces 50% cell death (IC50) at a concentration of 186 μg/mL at 48 h post-treatment in the HT-29 cell line. Cytotoxicity results showed a dose-dependent decrease in cell viability in the HT-29 cell line. However, increasing Aronia extract concentrations showed no similar effect on the HUVEC cell line. The hTERT protein concentration in HT-29 cells was 1.9-fold higher than that of HUVEC cells. Increasing concentrations of Aronia extract was linked with a significant decrease in hTERT protein level in HT-29 cells, whereas the hTERT protein concentration in HUVEC cells did not change significantly. Conclusions: Our results suggest that A. melanocarpa may be a potential therapeutic agent for anticarcinogenic activity. Also, the anti-proliferative effects of Aronia extract may be attributed, at least partly, to the decreased hTERT protein level of HT-29 cells.

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“…anticancer activity of Black Chokeberry with a model of Azoxymethane (AOM)/Dextran Sulphate sodium (DSS) and Caco-2 mouse cells was used to evaluate the anticancer activity of Black Chokeberry. Reduces the proliferation of Caco-2 cancer cells through decreased expression of cytokines, and glutaminase in natural therapies for the prevention of CRC [39].…”

Section: Black Chokeberrymentioning

confidence: 99%

Anthocyanin as Colorectal Anticancer: A Brief Review

Siwanahono¹,

Putri²,

Azhar³

2023

IJASRE

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Colorectal Cancer (CRC) is dangerous cancer that causes many cases of death in the world. This cancer spike occurred in 2020 with 1.15 million cases and is expected to increase in 2040 by 1.92 million CRC cancer cases. Some of the most popular drugs used for CRC chemotherapy are 5-Fluorouracil, Oxaliplatin, and Irinotecan. The effects caused by chemotherapy using synthetic drugs are loss of appetite, fatigue, vomiting, numbness, hair loss, and low blood cell count. Anthocyanins are a group of flavonoid compounds and polyphenols with antioxidant, antimutagenic, and anticancer activity that can be developed as CRC anticancer. Anthocyanins do not cause side effects in CRC patients. This article is a review of anthocyanin activity to reduce the risk of colorectal cancer (CRC) in terms of molecular mechanisms, the proliferation ability of cancer cells, and promoting apoptosis of CRC cells.

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Aronia melanocarpa Elliot anthocyanins inhibit colon cancer by regulating glutamine metabolism

Cited by 17 publications

References 33 publications

Flavonoids Attentuate Cancer Metabolism by Modulating Redox State, lipid metabolism, and use of amino acids or ketone bodies

Flavonoids Attentuate Cancer Metabolism by Modulating Redox State, lipid metabolism, and use of amino acids or ketone bodies

A preliminary study of the anti-proliferative effect of Aronia Melanocarpa extract on human colon cancer cells and its relation with human TERT protein

Anthocyanin as Colorectal Anticancer: A Brief Review

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