Arrabidaea chica extract improves gait recovery and changes collagen content during healing of the Achilles tendon

Aro, Andréa Aparecida de; Simões, Gustavo Ferreira; Esquisatto, Marcelo Augusto Marretto; Foglio, Mary Ann; Carvalho, J.C.T.; Oliveira, Alexandre Leite Rodrigues de; Gomes, Luiz Fernando; Pimentel, Edson Rosa

doi:10.1016/j.injury.2012.08.055

Cited by 43 publications

(41 citation statements)

References 38 publications

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“…Liu et al () reported that the local application of safflower yellow improved tendon healing by up‐regulating expression of bFGF and collagen type I. Previous data from our group also showed the effectiveness of topical application of Aloe vera ointment and Arrabidaea chica extract during tendon healing, with higher MMP‐2 activity and higher collagen organization compared with control groups (Aro et al, ).…”

Section: Discussionsupporting

confidence: 59%

“…Our results indicated that tendons treated with C. officinalis showed higher concentrations of hydroxyproline, an indicator of total collagen content in the tissue, when compared with control tendons. Data obtained by our group (Aro et al, ) showed increased total collagen content in injured tendons in the inflammatory phase. This result was due to increased cell migration to the injured area with subsequent synthesis of collagen for the formation of granulation tissue.…”

Section: Discussionmentioning

confidence: 61%

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Effect of Calendula Officinalis Cream on Achilles Tendon Healing

Aro

Perez

Vieira

et al. 2014

The Anatomical Record

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In recent years, the scientific community has undertaken research on plant extracts, searching for compounds with pharmacological activities that can be used in diverse fields of medicine. Calendula officinalis L. is known to have antioxidant, anti-inflammatory, antibacterial, and wound healing properties when used to treat skin burns. Therefore, the purpose of this study was to analyze the effects of C. officinalis on the initial phase of Achilles tendon healing. Wistar rats were separated in three groups: Calendula (Cal)-rats with a transected tendon were treated with topical applications of C. officinalis cream and then euthanized 7 days after injury; Control (C)-rats were treated with only vehicle after transection; and Normal (N)-rats without tenotomy. Higher concentrations of hydroxyproline (an indicator of total collagen) and non-collagenous proteins were observed in the Cal group in relation to the C group. Zymography showed no difference in the amount of the isoforms of metalloproteinase-2 and of metalloproteinase-9, between C and Cal groups. Polarization microscopy images analysis showed that the Cal group presented a slightly higher birefringence compared with the C group. In sections of tendons stained with toluidine blue, the transected groups presented higher metachromasy as compared with the N group. Immunocytochemistry analysis for chondroitin-6-sulfate showed no difference between the C and Cal groups. In conclusion, the topical application of C. officinalis after tendon transection increases the concentrations of collagen and non-collagenous proteins, as well as the collagen organization in the initial phase of healing. Anat Rec, 298:428-435, 2015. V C 2014 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 61%

Effect of Calendula Officinalis Cream on Achilles Tendon Healing

Aro

Perez

Vieira

et al. 2014

The Anatomical Record

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“…during the tendon healing process. 4 Antimicrobial, 5 antiinflammatory, 6 and antioxidant 7 potentials of this species have also been reported.…”

Section: Introductionmentioning

confidence: 80%

Chitosan–tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity

Servat-Medina¹,

González-Gómez²,

Reyes-Ortega³

et al. 2015

IJN

103

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Natural products using plants have received considerable attention because of their potential to treat various diseases. Arrabidaea chica (Humb. & Bonpl.) B. Verlot is a native tropical American vine with healing properties employed in folk medicine for wound healing, inflammation, and gastrointestinal colic. Applying nanotechnology to plant extracts has revealed an advantageous strategy for herbal drugs considering the numerous features that nanostructured systems offer, including solubility, bioavailability, and pharmacological activity enhancement. The present study reports the preparation and characterization of chitosan–sodium tripolyphosphate nanoparticles (NPs) charged with A. chica standardized extract (AcE). Particle size and zeta potential were measured using a Zetasizer Nano ZS. The NP morphological characteristics were observed using scanning electron microscopy. Our studies indicated that the chitosan/sodium tripolyphosphate mass ratio of 5 and volume ratio of 10 were found to be the best condition to achieve the lowest NP sizes, with an average hydrodynamic diameter of 150±13 nm and a zeta potential of +45±2 mV. Particle size decreased with AcE addition (60±10.2 nm), suggesting an interaction between the extract’s composition and polymers. The NP biocompatibility was evaluated using human skin fibroblasts. AcE-NP demonstrated capability of maintaining cell viability at the lowest concentrations tested, stimulating cell proliferation at higher concentrations. Antiulcerogenic activity of AcE-NP was also evaluated with an acute gastric ulcer experimental model induced by ethanol and indomethacin. NPs loaded with A. chica extract reduced the ulcerative lesion index using lower doses compared with the free extract, suggesting that extract encapsulation in chitosan NPs allowed for a dose reduction for a gastroprotective effect. The AcE encapsulation offers an approach for further application of the A. chica extract that could be considered a potential candidate for ulcer-healing pharmaceutical systems.

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“…However, in this study, positive changes were observed when GT was administered together with a glycine diet. Our group has searched for different therapies, such as the use of a low level laser (8,51), electroacupuncture (45) and plant extracts (46,57), to improve the structure of the Achilles tendon, considering biochemical and structural elements after partial rupture. These alternatives mainly aim to accelerate tissue healing because the tendon shows low vascularity and cellularity, which directly influences the tissue remodeling and recovery time.…”

Section: Discussionmentioning

confidence: 99%

Green tea and glycine aid in the recovery of tendinitis of the Achilles tendon of rats

Vieira

Guerra

Oliveira

et al. 2014

Connective Tissue Research

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Arrabidaea chica extract improves gait recovery and changes collagen content during healing of the Achilles tendon

Cited by 43 publications

References 38 publications

Effect of Calendula Officinalis Cream on Achilles Tendon Healing

Effect of Calendula Officinalis Cream on Achilles Tendon Healing

Chitosan–tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity

Green tea and glycine aid in the recovery of tendinitis of the Achilles tendon of rats

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Arrabidaea chica extract improves gait recovery and changes collagen content during healing of the Achilles tendon

Cited by 43 publications

References 38 publications

Effect of Calendula Officinalis Cream on Achilles Tendon Healing

Effect of Calendula Officinalis Cream on Achilles Tendon Healing

Chitosan&ndash;tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and&nbsp;antiulcerogenic activity

Green tea and glycine aid in the recovery of tendinitis of the Achilles tendon of rats

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Chitosan–tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity