Arrhythmias in two patients with left ventricular bypass transplants.

Kennelly, Brian M.; Corte, Pamplona; Losman, Jacques G.; Barnard, Christiaan N.

doi:10.1136/hrt.38.7.725

Cited by 12 publications

(6 citation statements)

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“…Nonetheless, most VAs in HHTx are related to the underlying recipient heart disease 9 and are clinically challenging because the recipient heart often remains functionally important. HHTx, which was originally performed as a biological LV assist device, 10 evolved into a biventricular assist configuration after the report of 2 patients who experienced heart failure related to recipient heart ventricular fibrillation 11 . In the later configuration, recipient VAs are often well tolerated and their diagnosis requires careful physical examination searching for the disappearance of the irregular pulse pattern related to donor heart parasystole.…”

Section: Discussionmentioning

confidence: 99%

“…HHTx, which was originally performed as a biological LV assist device, 10 evolved into a biventricular assist configuration after the report of 2 patients who experienced heart failure related to recipient heart ventricular fibrillation. 11 In the later configuration, recipient VAs are often well tolerated and their diagnosis requires careful physical examination searching for the disappearance of the irregular pulse pattern related to donor heart parasystole. Discrimination of the 2 superimposed rhythms on standard 12-lead ECG can be difficult, and some authors used echocardiography to identify which heart was concerned by the arrhythmia.…”

Section: Discussionmentioning

confidence: 99%

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Successful catheter ablation of recipient left ventricular tachycardia 26 years after heterotopic heart transplantation

Laredo

Varnous

Balagny

et al. 2017

HeartRhythm Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Successful catheter ablation of recipient left ventricular tachycardia 26 years after heterotopic heart transplantation

Laredo

Varnous

Balagny

et al. 2017

HeartRhythm Case Reports

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“…He remained well for four months, when he experienced the first of several attacks of paroxysmal ventricular tachycardia of his own heart, requiring electrical defibrillation and drug treatment. 5 In May 1976 he was admitted with bacterial endocarditis due to Staphylococcus aureus. He then suffered an acute myocardial infarction in his own heart.…”

Section: Casementioning

confidence: 99%

Long-term survival after orthotopic and heterotopic cardiac transplantation.

Cooper¹,

Charles²,

Fraser³

et al. 1980

BMJ

Self Cite

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“…The use of pacemaker systems in heterotopic heart transplantation 16,17 Experimental studies showed that with synchronous pacing of both hearts the extensively damaged recipient ventricle failed to open the aortic valve. It follows, therefore, that some stasis will occur within this dilated left ventricle with the subsequent possibility of thrombus formation.…”

Section: Clinical Studiesmentioning

confidence: 99%

Transplantation of the heart: An overview of 40 years' clinical and research experience at Groote Schuur Hospital and the University of Cape Town: Part I. Surgical experience and clinical studies

Hassoulas

2012

S Afr Med J

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his team performed the world's first human-tohuman heart transplant operation on 3 December 1967. It was a major historical event and a significant breakthrough for medical science. This and subsequent events received front-page media coverage around the world for months on end, describing all aspects in detail and giving progress reports on the postoperative course of the patients.Between December 1967 and November 1974, exclusively orthotopic heart transplantation was performed. Ten such heart transplants were done, and a heart and lung transplant was also performed in 1971. [1][2][3][4][5][6] Of the 10 patients who received orthotopic heart transplants, 4 lived for more than 18 months; 2 of them became long-term survivors, one living for over 13 years and the other for over 24 years. This last patient is remarkable not only for the length of his survival but for excellent recovery from the operation in spite of severe cardiac atherosclerosis at the time of the surgery. Within 3 months he had returned to work and did not miss a single day's work until he retired 15 years later. He died from a cerebrovascular accident after unsuccessful peripheral vascular surgery and lower limb amputations.In the 1971 transplantation of a heart and both lungs, the heart was placed in the orthotopic position and the lungs were transplanted separately at the left and right main bronchi. The patient died 23 days later from pneumonia and bronchopleural fistula complications. This operation was considered quite an achievement, as two such operations were performed in the USA at about the same time, but the patients did not survive longer than a day or two. This early experience established sound criteria for the selection of recipients who would derive maximum benefit from heart transplantation. Experience was also obtained in methods of diagnosis and treatment of acute rejection. 7,8 Heterotopic heart transplantationClinical experience with orthotopic heart transplantation showed that complex and difficult-to-manage situations often emerge. It has been established that full recovery of donor heart function takes place over hours to days after transplantation. Anoxic damage and myocardial cell necrosis of the graft can occur during harvesting or at implantation, especially if myocardial protection has been inadequate or prolonged. Air embolisation to the coronary arteries often contributes to this situation. However, such damage is mostly caused by the excessive catecholamine secretion that results from brain death of the donor. Poor function of the donor heart has resulted in many recipient deaths. Similarly, many recipient deaths occurred as a result of pulmonary hypertension, as the donor right ventricle is unaccustomed to pumping against elevated pulmonary pressures, resulting in acute irreversible right heart failure. The recipient's right ventricle, although diseased, has adapted with time and has hypertrophied, making it capable of maintaining the pulmonary circulation.These observations were cause for serious concern and le...

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Arrhythmias in two patients with left ventricular bypass transplants.

Cited by 12 publications

References 1 publication

Successful catheter ablation of recipient left ventricular tachycardia 26 years after heterotopic heart transplantation

Successful catheter ablation of recipient left ventricular tachycardia 26 years after heterotopic heart transplantation

Long-term survival after orthotopic and heterotopic cardiac transplantation.

Transplantation of the heart: An overview of 40 years' clinical and research experience at Groote Schuur Hospital and the University of Cape Town: Part I. Surgical experience and clinical studies

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