Long-term survival after orthotopic and heterotopic cardiac transplantation.

Cooper, D. K. C.; Charles, Richard G.; Fraser, R C; Beck, Walter; Barnard, Christiaan N.

doi:10.1136/bmj.281.6248.1093

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…The 1‐yr survival at that time was approximately 50%, with rejection and infection being the main problems [10–12]. About 20% of patients, however, were long‐term survivors [12,13].…”

Section: Cape Townmentioning

confidence: 99%

Outwitting evolution*

Cooper¹

2010

Xenotransplantation

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The author pays tribute to those who stimulated him to follow a career in clinical cardiothoracic surgery and experimental transplantation. Highlights of his career have been in contributing to (i) the first hypothermic perfusion storage of the donor heart to be used successfully in clinical practice, (ii) hormonal therapy in the management of the brain-dead potential organ donor, (iii) the identification of Gal alpha 1,3Gal as the major antigenic target for primate natural anti-pig antibodies, (iv) the 2- to 6-month survival of alpha1,3-galactosyltransferase gene-knockout hearts transplanted into baboons, and (v) the 3- to 12-month normoglycemia following the transplantation of islets from CD46-transgenic pigs into diabetic monkeys. Many friends have been made through a mutual interest in transplantation, particularly through the activities of the International Xenotransplantation Association (IXA). The author thanks the many mentors, colleagues, and research fellows with whom it has been his great privilege and pleasure to work during the past several decades, and readily acknowledges that it is largely their contributions that have enabled him to receive the honor of Honorary Membership of the IXA.

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“…The 1‐yr survival at that time was approximately 50%, with rejection and infection being the main problems [10–12]. About 20% of patients, however, were long‐term survivors [12,13].…”

Section: Cape Townmentioning

confidence: 99%

Outwitting evolution*

Cooper¹

2010

Xenotransplantation

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“…Only two patients (both men, aged 59 and 47 years respectively) underwent this procedure: the first succumbed to a pulmonary embolus -l l l days after transplantation, and the other remains well and actively employed six and a quarter years later; this patient has been reinvestigated and reported recently (Cooper et al 1980). Both patients suffered recurrent attacks of recipient heart dysrhythmias including ventricular fibrillation, during which time the donor heart satisfactorily supported the circulation alone, but for this reason the technique was superseded by biventricular bypass.…”

Section: Left Ventricular Bypassmentioning

confidence: 99%

“…Nevertheless, 4 patients (44%) survived for more than one year, enjoying an excellent quality of life, and 2 remain active today twelve and ten years respectively since operation (Cooper et al 1980). These 2 long-term survivors were the only patients under the age of 50 years at the time of operation.…”

Section: Introductionmentioning

confidence: 99%

Clinical Transplantation of the Heart: A Review of 13 Years’ Personal Experience¹

Barnard

Cooper

1981

J R Soc Med

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The results of the heart transplantation operations performed personally by one surgeon (CNB) at Groote Schuur Hospital between 1967 and 1980 are reviewed. Of 9 orthotopic transplants performed between 1967 and 1973, 4 survived for more than one year and 2 remain alive today twelve and ten years later. Of 11 heterotopic transplants performed since 1974, one-year patient survival has been 82%, though one patient survived on his own heart after irreversible graft rejection. Three of the original 4 patients remain alive over five years later. These results are rather better than the overall results of our unit, where a total of 37 heterotopic transplants has been performed; the possible reasons for this are discussed. One patient, previously unreported, who underwent transplantation of the heart and both lungs in 1971, died after 23 days from pulmonary complications. Heterotopic transplantation using a xenograft (baboon or chimpanzee heart) has been performed on two occasions as a means of temporary circulatory support in patients with acutely failing hearts when no human donor was available. The chimpanzee heart supported the circulation satisfactorily for four days.

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Cardiac Retransplantation - Indications and Results

Taniguchi¹,

Cooper²

The Transplantation and Replacement of Thoracic Organs

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Long-term survival after orthotopic and heterotopic cardiac transplantation.

Abstract: Summary and conclusionsFive long-term survivors of heart transplantation were reinvestigated. Two patients had undergone orthotopic heart transplantation over 11 and 9 years earlier and constitute two of the world's longest-surviving patients after this procedure. Three

Cited by 8 publications

References 6 publications

Outwitting evolution*

Outwitting evolution*

Clinical Transplantation of the Heart: A Review of 13 Years’ Personal Experience¹

Cardiac Retransplantation - Indications and Results

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Long-term survival after orthotopic and heterotopic cardiac transplantation.

Abstract: Summary and conclusionsFive long-term survivors of heart transplantation were reinvestigated. Two patients had undergone orthotopic heart transplantation over 11 and 9 years earlier and constitute two of the world's longest-surviving patients after this procedure. Three

Cited by 8 publications

References 6 publications

Outwitting evolution*

Outwitting evolution*

Clinical Transplantation of the Heart: A Review of 13 Years’ Personal Experience1

Cardiac Retransplantation - Indications and Results

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Clinical Transplantation of the Heart: A Review of 13 Years’ Personal Experience¹