Arrhythmogenic and Cardiodepressive Effects of Contrast Media on Isolated Rat Atria

Refsum, Helge; Passwal, Masjedi

doi:10.1097/00004424-197809000-00009

Cited by 12 publications

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“…Therefore, the time course and the magnitude of the effects we observed in this study have to be interpreted in the light of this. A 10% contrast medium concentration was chosen since this concentration previously has been shown to induce significant mechanical and electrophysiological effects in isolated myocardial preparations (Refsum & Passwal 1978;Hotvedt & Refsum 1980;Chuck et al 1984). Both the direction and the magnitude of the observed mechanical effects of contrast media in vitro are consistent with the haemodynamic effects observed in vivo (Higgins et al 1980;Deutsch el al.…”

Section: Electrophysiological Effectsmentioning

confidence: 94%

Electromechanical Effects of Two Low Osmolality Contrast Media, Ioxaglate and Iohexol, on Isolated Rat Atria

Tande¹,

Klew

Refsum³

1990

Pharmacology & Toxicology

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This study aimed at investigating the direct effects of two low osmolality radiographic contrast media, iohexol (non-ionic) and ioxaglate (ionic), on transmembrane action potentials, contractile force and refractoriness of isolated rat atrial preparations. Superfused with 10% solution, ioxaglate induced a biphasic mechanical response, initially decreasing and thereafter increasing contractile force. The same concentration of iohexol only increased contractile force. The two contrast media increased the resting membrane potential, action potential amplitude and rate of depolarization to the same extent. Iohexol prolonged repolarization. Both contrast media decreased the effective refractory period. The direct effects of contrast media on myocardial contractility in this study can explain the different haemodynamic effects of iohexol and ioxaglate in vivo. The observed effects on the action potentials in vitro can explain commonly observed ECG changes during coronary arteriography. The changes in depolarization, repolarization and refractoriness are probably related to the arrhythmogenic properties of these contrast media.

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Section: Electrophysiological Effectsmentioning

confidence: 94%

Electromechanical Effects of Two Low Osmolality Contrast Media, Ioxaglate and Iohexol, on Isolated Rat Atria

Tande¹,

Klew

Refsum³

1990

Pharmacology & Toxicology

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Comparison of ionic and non‐ionic contrast agents in cardiac catheterization: The effects of ventriculography and coronary arteriography on hemodynamics, electrocardiography, and serum creatinine

Cooper

Reed

1991

Cathet. Cardiovasc. Diagn.

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We compared two nonionic contrast agents (ioxaglate and iohexol) with an ionic agent (Renografin-76) on the effects of ventriculography and coronary arteriography on the hemodynamics, electrocardiography, and serum creatinine in one hundred consecutive patients. Patients were randomized to nonionic or ionic groups and were further evaluated regarding the effect of fluid loading prior to catheterization. The ionic agent more often produced subjective reactions (rash, nausea/vomiting). Following ventriculography, both ionic and non-ionic agents produced an increase in left ventricular end diastolic pressure and this effect was undetermined by fluid loading. Nonionic agents decreased aortic diastolic pressure following ventriculography and this effect was unaltered by fluid loading. In contrast, the ionic agent produced profound hemodynamic changes (drop in both systolic and diastolic pressures) following coronary arteriography and these effects were blunted by prior fluid loading. The ionic agent produced significantly greater heart rate slowing and prolongation of the QT interval than the nonionic agents, suggesting that the latter are potentially less arrhythmogenic. Comparing the two non-ionic agents, we found that both decreased aortic diastolic pressure and increased left ventricular end diastolic pressure following ventriculography. Iohexol produced greater heart rate slowing than did ioxaglate, though the increase was minor compared to the ionic agent. Neither nonionic agent appeared to significantly affect serum creatinine. In conclusion, the two nonionic agents appeared to offer significant advantages over the ionic agent in ventriculography and coronary arteriography.

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Contrast Media in the Cardiovascular System

Higgins¹

1984

Radiocontrast Agents

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Arrhythmogenic and Cardiodepressive Effects of Contrast Media on Isolated Rat Atria

Cited by 12 publications

References 0 publications

Electromechanical Effects of Two Low Osmolality Contrast Media, Ioxaglate and Iohexol, on Isolated Rat Atria

Electromechanical Effects of Two Low Osmolality Contrast Media, Ioxaglate and Iohexol, on Isolated Rat Atria

Comparison of ionic and non‐ionic contrast agents in cardiac catheterization: The effects of ventriculography and coronary arteriography on hemodynamics, electrocardiography, and serum creatinine

Contrast Media in the Cardiovascular System

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