Arrhythmogenic Evidence for Epicardial Adipose Tissue: Heart Rate Variability and Turbulence are Influenced by Epicardial Fat Thickness

Balcıoğlu, Akif Serhat; Çiçek, Davran; Akıncı, Si̇nan; Eldem, Halil Olcay; Bal, Uğur Abbas; Okyay, Kaan; Müderrisoğlu, Haldun

doi:10.1111/pace.12512

Cited by 53 publications

(31 citation statements)

References 24 publications

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“…Third, increased epicardial fat thickness has been described in obese individuals 43 and has been associated with altered atrial electrophysiology 44 and sympathovagal imbalance of the atria. 45 In small case-control studies, increased epicardial fat has been associated with AF. 46, 47 …”

Section: Discussionmentioning

confidence: 99%

Associations of obesity and body fat distribution with incident atrial fibrillation in the biracial health aging and body composition cohort of older adults

Aronis

Wang

Phillips

et al. 2015

American Heart Journal

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Introduction Obesity is a well-recognized risk factor for atrial fibrillation (AF) yet adiposity measures other than body mass index (BMI) have had limited assessment in relation to AF risk. We examined the associations of adiposity measures with AF in a biracial cohort of older adults. Given established racial differences in obesity and AF, we assessed for differences by black and white race in relating adiposity and AF. Methods We analyzed data from 2,717 participants of the Health, Aging, and Body Composition Study. Adiposity measures were BMI, abdominal circumference, subcutaneous and visceral fat area, and total and percent fat mass. We determined the associations between the adiposity measures and 10-year incidence of AF using Cox proportional-hazards models, and assessed for their racial differences in these estimates. Results In multivariable-adjusted models, 1-standard deviation increases in BMI, abdominal circumference and total fat mass were associated with a 13–16% increased AF risk (hazard ratio [HR]: 1.14, 95% confidence interval [CI]: 1.02–1.28, HR: 1.16, 95%CI: 1.04–1.28, and HR: 1.13, 95% CI: 1.002–1.27). Subcutaneous and visceral fat areas were not significantly associated with incident AF. We did not identify racial differences in the associations between the adiposity measures and AF. Conclusion BMI, abdominal circumference, and total fat mass are associated with risk of AF over 10 years among white and black older adults. Obesity is one of a limited number of modifiable risk factors for AF; future studies are essential to evaluate how obesity reduction can modify the incidence of AF.

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Section: Discussionmentioning

confidence: 99%

Associations of obesity and body fat distribution with incident atrial fibrillation in the biracial health aging and body composition cohort of older adults

Aronis

Wang

Phillips

et al. 2015

American Heart Journal

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“…Several studies show a close relation between epicardial fat and cardiac autonomic function [4][5][6]. It was shown that the cardiac ganglionated plexus in the epicardial fat integrates the autonomic innervation between the extrinsic and intrinsic cardiac autonomic nervous system and affects atrial electrophysiology and pathophysiology [4].…”

Section: To the Editorsmentioning

confidence: 99%

“…Additionally, Balcioglu et al showed that sympathovagal imbalance, detected by heart rate variability and turbulence parameters, is related to epicardial fat thickness. As sympathovagal imbalance is a predictor of arrhythmic events, epicardial fat may play an important arrhythmogenic role [6].…”

Section: To the Editorsmentioning

confidence: 99%

Epicardial fat and liver disease; the contribution of cardio autonomic nervous system function

Ulucan

Katlandur

Kaya

2015

Journal of Hepatology

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“…[19][20][21] Importantly, recent studies have also indicated a close relationship between EAT and myocardial autonomic function. 31,32 Many EAT-derived factors can directly modulate the electrophysiological properties and ion currents of myocytes and may promote arrhythmogenesis. 33 Moreover, EAT contains both adrenergic and cholinergic nerves which interact with the extrinsic SNS and para-SNS.…”

Section: Eat and Cardiac Sympathetic Denervationmentioning

confidence: 99%

Increased Epicardial Adipose Tissue Volume Correlates With Cardiac Sympathetic Denervation in Patients With Heart Failure

Parisi

Rengo

Perrone‐Filardi

et al. 2016

Circulation Research

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Rationale: It has been reported that epicardial adipose tissue (EAT) may affect myocardial autonomic function.Objective: The aim of this study was to explore the relationship between EAT and cardiac sympathetic nerve activity in patients with heart failure. Methods and Results:In 110 patients with systolic heart failure, we evaluated the correlation between echocardiographic EAT thickness and cardiac adrenergic nerve activity assessed by Conclusions:This study provides the first evidence of a direct correlation between increased EAT thickness and cardiac sympathetic denervation in heart failure. (Circ Res.

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Arrhythmogenic Evidence for Epicardial Adipose Tissue: Heart Rate Variability and Turbulence are Influenced by Epicardial Fat Thickness

Abstract: Sympathovagal imbalance, detected by HRV and HRT parameters, is related to EAT thickness. As sympathovagal imbalance is a predictor of arrhythmic events, EAT may play an important arrhythmogenic role not limited to atrial fibrillation.

Cited by 53 publications

References 24 publications

Associations of obesity and body fat distribution with incident atrial fibrillation in the biracial health aging and body composition cohort of older adults

Associations of obesity and body fat distribution with incident atrial fibrillation in the biracial health aging and body composition cohort of older adults

Epicardial fat and liver disease; the contribution of cardio autonomic nervous system function

Increased Epicardial Adipose Tissue Volume Correlates With Cardiac Sympathetic Denervation in Patients With Heart Failure

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