Increased Epicardial Adipose Tissue Volume Correlates With Cardiac Sympathetic Denervation in Patients With Heart Failure

Parisi, Valentina; Rengo, Giuseppe; Perrone‐Filardi, Pasquale; Pagano, Gennaro; Femminella, Grazia Daniela; Paolillo, Stefania; Petraglia, Laura; Gambino, Giuseppina; Caruso, Aurelio; Grimaldi, M.; Baldascino, Francesco; Nolano, Maria; Elia, Andrea; Cannavò, Alessandro; Bellis, Antonio De; Coscioni, Enrico; Pellegrino, Teresa; Cuocolo, Alberto; Ferrara, Nicola; Leosco, Dario

doi:10.1161/circresaha.115.307765

Cited by 82 publications

(60 citation statements)

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“…Recent data indicate a possible role of adipose tissue in modulating cardiac function [12, 42, 69]. It was reported that cardiac adipocytes are able to release substances that suppress the contraction of cardiomyocytes by attenuating intracellular Ca 2+ levels [49].…”

Section: Discussionmentioning

confidence: 99%

Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor

et al. 2017

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Several studies have demonstrated the expression of odorant receptors (OR) in various human tissues and their involvement in different physiological and pathophysiological processes. However, the functional role of ORs in the human heart is still unclear. Here, we firstly report the functional characterization of an OR in the human heart. Initial next-generation sequencing analysis revealed the OR expression pattern in the adult and fetal human heart and identified the fatty acid-sensing OR51E1 as the most highly expressed OR in both cardiac development stages. An extensive characterization of the OR51E1 ligand profile by luciferase reporter gene activation assay identified 2-ethylhexanoic acid as a receptor antagonist and various structurally related fatty acids as novel OR51E1 ligands, some of which were detected at receptor-activating concentrations in plasma and epicardial adipose tissue. Functional investigation of the endogenous receptor was carried out by Ca2+ imaging of human stem cell-derived cardiomyocytes. Application of OR51E1 ligands induced negative chronotropic effects that depended on activation of the OR. OR51E1 activation also provoked a negative inotropic action in cardiac trabeculae and slice preparations of human explanted ventricles. These findings indicate that OR51E1 may play a role as metabolic regulator of cardiac function.Electronic supplementary materialThe online version of this article (doi:10.1007/s00395-017-0600-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor

et al. 2017

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“…20 Of Interest, indirect evidence for the local toxic effect of cardiac ectopic fat on AF was recently shown by a surgical biopsy study. 21 That study demonstrated the increased concentration of norepinephrine, a catecholamine that invokes a sympathetic response, in epicardial adipose tissue, as compared to subcutaneous adipose tissue or plasma. 21 These findings support the biological plausibility of a relation between pericardial fat and AF as greater local catecholamine concentration may increase the occurrence of arrhythmia.…”

Section: Discussionmentioning

confidence: 93%

“…21 That study demonstrated the increased concentration of norepinephrine, a catecholamine that invokes a sympathetic response, in epicardial adipose tissue, as compared to subcutaneous adipose tissue or plasma. 21 These findings support the biological plausibility of a relation between pericardial fat and AF as greater local catecholamine concentration may increase the occurrence of arrhythmia. Nevertheless, we did not find associations between pericardial fat with incident AF after further adjusting for risk factor determinants of AF and BMI.…”

Section: Discussionmentioning

confidence: 93%

Relation of Pericardial Fat, Intrathoracic Fat, and Abdominal Visceral Fat With Incident Atrial Fibrillation (from the Framingham Heart Study)

Lee

Yin

Hoffmann

et al. 2016

The American Journal of Cardiology

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Obesity is associated with increased risk of developing atrial fibrillation (AF). Different fat depots may have differential associations with cardiac pathology. We examined the longitudinal associations between pericardial, intrathoracic, and visceral fat with incident AF. We studied Framingham Heart Study Offspring and Third Generation Cohorts who participated in the multi-detector computed tomography sub-study examination 1. We constructed multivariable-adjusted Cox proportional hazard models for risk of incident AF. Body mass index (BMI) was included in the multivariable-adjusted model as a secondary adjustment. We included 2,135 participants (53.3% women; mean age 58.8 years). During a median follow-up of 9.7 years, we identified 162 cases of incident AF. Across the increasing tertiles of pericardial fat volume, age- and sex-adjusted incident AF rate per 1000 person-years of follow-up were 8.4, 7.5, and 10.2. Based on an age- and sex-adjusted model, greater pericardial fat [hazard ratio (HR) 1.17, 95% confidence interval (CI) 1.03-1.34] and intrathoracic fat (HR 1.24, 95% CI 1.06-1.45) were associated with increased risk of incident AF. The HRs (95% CI) for incident AF were 1.13 (0.99-1.30) for pericardial fat, 1.19 (1.01-1.40) for intrathoracic fat, and 1.09 (0.93-1.28) for abdominal visceral fat after multivariable adjustment. After additional adjustment of BMI, none of the associations remained significant (all p>0.05). Our findings suggest that cardiac ectopic fat depots may share common risk factors with AF, which may have led to a lack of independence in the association between pericardial fat with incident AF.

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“…In this issue of Circulation Research, Parisi et al 18 report the results of their study looking at the relationship between epicardial adipose density and cardiac sympathetic denervation in patients with HF. The study involved 110 patients with HF of ischemic and nonischemic pathogenesis enrolled at the HF clinic of Federico II University of Naples, Italy.…”

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confidence: 99%

Cardiac Sympathetic Denervation in the Failing Heart

White

2016

Circulation Research

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Increased Epicardial Adipose Tissue Volume Correlates With Cardiac Sympathetic Denervation in Patients With Heart Failure

Cited by 82 publications

References 50 publications

Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor

Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor

Relation of Pericardial Fat, Intrathoracic Fat, and Abdominal Visceral Fat With Incident Atrial Fibrillation (from the Framingham Heart Study)

Cardiac Sympathetic Denervation in the Failing Heart

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