Arsenic and Arsenic Compounds

Grund, Sabina C.; Hanusch, Kunibert; Wolf, Hans

doi:10.1002/14356007.a03_113.pub2

Cited by 88 publications

(15 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rubber trees grow only in the tropics, such as in Asia and West Africa, where they supplant food crops and are an environmental burden because of the heavy use of arsenic-based pesticides. [4][5][6] Synthetic rubber has been introduced to replace natural rubber in less demanding applications and to reduce the extensive culturing of rubber trees.…”

mentioning

confidence: 99%

Iron‐Catalyzed Polymerization of Isoprene and Other 1,3‐Dienes

Raynaud

Ritter

2012

Angewandte Chemie

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Iron‐Catalyzed Polymerization of Isoprene and Other 1,3‐Dienes

Raynaud

Ritter

2012

Angewandte Chemie

View full text Add to dashboard Cite

show abstract

“…By nature, heavy metals can be divided into two forms, which are organic and inorganic [6]. For example, inorganic As is more harmful than organic form due to the pentavalent inorganic compound of As that solubilizes in water to the weak acid form and produce arsenate [7] that affects people by inducing ground water contamination [8]. Heavy metals in the form of organic pollutant may gradually degrade into less harmful components through chemical or biological processes [9,10].…”

Section: Introductionmentioning

confidence: 99%

Understanding Potential Heavy Metal Contamination, Absorption, Translocation and Accumulation in Rice and Human Health Risks

Zakaria

Zulkafflee

Redzuan

et al. 2021

Plants

128

View full text Add to dashboard Cite

Rice is a worldwide staple food and heavy metal contamination is often reported in rice production. Heavy metal can originate from natural sources or be present through anthropogenic contamination. Therefore, this review summarizes the current status of heavy metal contamination in paddy soil and plants, highlighting the mechanism of uptake, bioaccumulation, and health risk assessment. A scoping search employing Google Scholar, Science Direct, Research Gate, Scopus, and Wiley Online was carried out to build up the review using the following keywords: heavy metals, absorption, translocation, accumulation, uptake, biotransformation, rice, and human risk with no restrictions being placed on the year of study. Cadmium (Cd), arsenic (As), and lead (Pb) have been identified as the most prevalent metals in rice cultivation. Mining and irrigation activities are primary sources, but chemical fertilizer and pesticide usage also contribute to heavy metal contamination of paddy soil worldwide. Further to their adverse effect on the paddy ecosystem by reducing the soil fertility and grain yield, heavy metal contamination represents a risk to human health. An in-depth discussion is further offered on health risk assessments by quantitative measurement to identify potential risk towards heavy metal exposure via rice consumption, which consisted of in vitro digestion models through a vital ingestion portion of rice.

show abstract

“…Arsenic is a toxic metalloid commonly present in many minerals as well as in food, water, soil and the air [3,4]. Particularly inorganic arsenic compounds are highly toxic and comprise numerous valence states including arsenic trioxide (As 2 O 3 ) and realgar [5].…”

Section: Introductionmentioning

confidence: 99%

Organoarsenic Compounds with In Vitro Activity against the Malaria Parasite Plasmodium falciparum

et al. 2020

View full text Add to dashboard Cite

The rapid development of parasite drug resistance as well as the lack of medications targeting both the asexual and the sexual blood stages of the malaria parasite necessitate the search for novel antimalarial compounds. Eleven organoarsenic compounds were synthesized and tested for their effect on the asexual blood stages and sexual transmission stages of the malaria parasite Plasmodium falciparum using in vitro assays. The inhibitory potential of the compounds on blood stage viability was tested on the chloroquine (CQ)-sensitive 3D7 and the CQ-resistant Dd2 strain using the Malstat assay. The most effective compounds were subsequently investigated for their effect on impairing gametocyte development and gametogenesis, using the gametocyte-producing NF54 strain in respective cell-based assays. Their potential toxicity was investigated on leukemia cell line Nalm-6 and non-infected erythrocytes. Five out of the 11 compounds showed antiplasmodial activities against 3D7, with half-maximal inhibitory concentration (IC50) values ranging between 1.52 and 8.64 µM. Three of the compounds also acted against Dd2, with the most active compound As-8 exhibiting an IC50 of 0.35 µM. The five compounds also showed significant inhibitory effects on the parasite sexual stages at both IC50 and IC90 concentrations with As-8 displaying the best gametocytocidal activity. No hemolytic and cytotoxic effect was observed for any of the compounds. The organoarsenic compound As-8 may represent a good lead for the design of novel organoarsenic drugs with combined antimalarial and transmission blocking activities.

show abstract

Arsenic and Arsenic Compounds

Cited by 88 publications

References 60 publications

Iron‐Catalyzed Polymerization of Isoprene and Other 1,3‐Dienes

Iron‐Catalyzed Polymerization of Isoprene and Other 1,3‐Dienes

Understanding Potential Heavy Metal Contamination, Absorption, Translocation and Accumulation in Rice and Human Health Risks

Organoarsenic Compounds with In Vitro Activity against the Malaria Parasite Plasmodium falciparum

Contact Info

Product

Resources

About