2015
DOI: 10.2174/2212697x02666150629174704
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Arsenic-exposed Keratinocytes Exhibit Differential microRNAs Expression Profile; Potential Implication of miR-21, miR-200a and miR-141 in Melanoma Pathway

Abstract: Long-term exposure to arsenic has been linked to cancer in different organs and tissues, including skin. Here, non-malignant human keratinocytes (HaCaT) were exposed to arsenic and its effects on microRNAs (miRNAs; miR) expression were analyzed via miRCURY LNA array analyses. A total of 30 miRNAs were found differentially expressed in arsenic-treated cells, as compared to untreated controls. Among the up-regulated miRNAs, miR-21, miR-200a and miR-141, are well known to be involved in carcinogenesis. Additional… Show more

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Cited by 38 publications
(20 citation statements)
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“…Arsenic induces human cancers including lung cancer42 and can affect the expression of certain miRNAs4344. Increasing evidence indicates that abnormal expression of miRNAs is associated with carcinogenesis45.…”
Section: Discussionmentioning
confidence: 99%
“…Arsenic induces human cancers including lung cancer42 and can affect the expression of certain miRNAs4344. Increasing evidence indicates that abnormal expression of miRNAs is associated with carcinogenesis45.…”
Section: Discussionmentioning
confidence: 99%
“…For example, the expression of hsa-mir-10a-5p, hsa-mir-182-5p and hsa-mir-19b-3p resulted to be up-regulated in HUVEC cells treated with 20 μM of arsenite 88 . On the other hand, arsenical exposure was able to induce the reduction of hsa-mir-34a-5p and let-7b and caused cumulative disruption to epigenetic regulation of hsa-mir-34a-5p expression in keratinocytes 89 . Moreover, hsa-mir-30a-5p is resulted to be up-regulated after arsenic trioxide treatment in liver cancer cells 88 whereas arsenical exposure significantly down-regulated the expression of hsa-mir-423-3p in rat liver tissues 90 .…”
Section: Discussionmentioning
confidence: 98%
“…They play pivotal roles during several biological processes, including tumorigenesis in melanoma (40,41). MiRNA expression levels are regulated in response to various factors, including toxicant stresses in the environment (42). Based on their genomic location, miRNAs are generally classified as 'intergenic' or 'intronic.'…”
Section: Discussionmentioning
confidence: 99%