Arsenic induced genotoxic and histopathological changes in male Swiss albino mice, Mus musculus

Mohapatra, Animesh Kumar; Rai, Deepika; Tyagi, Anika

doi:10.31018/jans.v3i2.210

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Tartrazine can affect the blood cell formation and may cause the abnormal sized erythrocytes. Studies in swiss albino mice reported similar changes in MCH treated with tartrazine [27]. In chronic experiments, MCH was decreased in test fishes in accordance with the increasing concentration of exposed tartrazine.…”

Section: Haematological Changes In Fishesmentioning

confidence: 52%

Haematological Changes in Fish Labeo rohita Exposed to the Azo Dye Tartrazine

Athira¹,

DS²

2023

Act Sci VetSci

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For the present study, azo dye tartrazine (acid yellow 23) having wide range of application in textiles and synthetic foods, was used to assess the toxic effects and biomarker responses in fish Labeo rohita (Hamilton, 1822), commonly known as rohu. In toxicity studies haematological estimation is recognized as significant before many years. Acute (T1, T2 and T3 for 96 hours) and chronic (CT1 and CT2 for 75 days) bioassays were conducted. Major physico-chemical characteristics of aquaria water were analysed and recorded in regular intervals of experiment. After the experimental period, blood was collected and major haematological parameters; Hb, TC, RBC, PCV, MCV, MCH and MCHC were analysed. The results show that parameters Hb, RBC, PCV, MCV, MCH were significantly reduced and TC was significantly increased in highest concentration of acute test (T3) and in chronic tests (CT1 and CT2). The changes in haematological parameters can reflect the physiological status of animal and indicates the environmental conditions where they being. The experimental study establishes that haematological indices such as Hb, TC, RBC, PCV, MCV, and MCH are good biomarkers of the tartrazine exposure in fishes..

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Section: Haematological Changes In Fishesmentioning

confidence: 52%

Haematological Changes in Fish Labeo rohita Exposed to the Azo Dye Tartrazine

Athira¹,

DS²

2023

Act Sci VetSci

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“…Disruption of hepatocytic plates, the breakdown of hepatocytes evidenced by cell membrane rupture, cytoplasmic vacuolization, and nuclear pycnosis were all signs of histological changes in the liver tissue of Cd-treated rats. (Mohapatra et al, 2013). and ElRefaiy (2020) who observed severe hepatic The histological alterations seen in livers treated with Cd may be explained by the production of extremely reactive radicals and subsequent lipid peroxidation.…”

Section: Discussionmentioning

confidence: 96%

The ameliorative effect of clove oil against the hepatotoxicity induced via cadmium exposure in rats.

Elgharib

Abdelhamid

Elshopakey

et al. 2022

Preprint

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Cadmium considered a widely distributed toxic heavy metal in the environment that affects various organs of animals and humans through the induction of oxidative stress. Clove oil of plant origin; is one of the most effective aromatic antioxidants due to its high phenolic and flavonoid contents. In addition to its antioxidant effects, it has anti-inflammatory and anti-carcinogenic effects. To study the effect of clove oil against Cd toxicity, Four groups contained 5 rats each: group A (control), group B (15 mg\kg CdCl2), group C (clove oil 200mg\kg), group D (CdCl2 15 mg/kg + clove oil 200 mg\kg). All the groups swallowed by gastric lavage for 30 days. Then, all rats were sacrificed; liver tissues and blood samples were collected. The results revealed that Cd-induced hematological abnormalities with prominent anemia and hepatic damage through increasing the activities of liver enzymes ALT, AST, ALP, and the levels of direct and total bilirubin. On the other hand, levels of total protein and albumin were decreased. The hepatic antioxidant profiles exhibited decreased SOD, catalase enzyme, GST, and GSH. Meanwhile, the MDA level was increased. Inflammation of liver caused by cadmium reflected by the increased levels of TNF-α and caspase 3. Interestingly, clove oil ameliorated the Cd-induced toxicity in rats.

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