Arsenic-induced Histological Alterations in Various Organs of Mice

As, Noman; Dilruba, Sayada; Mohanto, Nayan Chandra; Rahman, Lutfur; Khatun, Zehedina; Riad, W.; Mamun, Abdullah Al; Alam, Sarwar; Aktar, Sharmin; Chowdhury, Shyamapriya; Saud, Zahangir Alam; Rahman, Zillur; Hossain, Khaled; Haque, Azizul

doi:10.4172/2157-7099.1000323

Cited by 16 publications

(9 citation statements)

References 30 publications

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“…This procedure demonstrates pretty well every practical histopathologic with additional diagnostic studies such as histological examination in microscopy scission. [18][19][20] …”

Section: Histological Treatmentmentioning

confidence: 99%

Arsenic Status and Speciation in Chicken Heart Tissues

Pizarro

Román

Gómez

et al. 2015

J. Chil. Chem. Soc.

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SUMMARYThis study evaluated the total and main arsenic species in chicken heart tissues. The experimental study was carried out using two sets of samples. In the first one, 30-day-old chickens were exposed to sodium arsenate, using spiked drinking water. These chickens grew normally and were killed after fifty days of arsenic exposure. The second sets were edible chickens were nonexposed to sodium arsenate for a parallel study. The total arsenic and arsenic species content in the exposed samples were at least twice those in the normal edible chicken. One important aspect is the capability of the heart tissues to preconcentrate the most toxic species, arsenite, in the exposed chicken. Arsenobetaine was also detected in fat in the non exposed chicken.This study could be a way of establishing similarities and differences with humans exposed to the same As(V) species, to ascertain whether chickens can be used in arsenic metabolism evaluation and the results extrapolated to humans.

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“…This procedure demonstrates pretty well every practical histopathologic with additional diagnostic studies such as histological examination in microscopy scission. [18][19][20] …”

Section: Histological Treatmentmentioning

confidence: 99%

Arsenic Status and Speciation in Chicken Heart Tissues

Pizarro

Román

Gómez

et al. 2015

J. Chil. Chem. Soc.

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“…Histopathology and serum biochemistry serve as an initial indicator of physiological dysfunction and the incidence of liver intoxication [42, 43]. To observe NaAsO 2 -induced liver alterations, we performed histopathology on liver tissues.…”

Section: Discussionmentioning

confidence: 99%

In Vivo and In Vitro Hepatoprotective Effects of Geranium koreanum Methanolic Extract via Downregulation of MAPK/Caspase‐3 Pathway

Akanda

Kim

Ahn

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Geranium koreanum (GK) is an indigenous Chinese herbal medicine widely used for the treatment of various inflammation and liver disorders. However, the exact mechanism of action of GK remains unknown. This study aimed to investigate the protective effect and related molecular mechanism of GK on NaAsO2-induced cytotoxicity in HepG2 cells and liver damage in mice. The cytoprotective role of GK was assessed on HepG2 cells using MTT assay. Oxidative stress and lactate dehydrogenase levels were measured with ROS and LDH assay. Histopathology and serum enzymes levels were estimated. The molecular mechanism was evaluated by qPCR and immunoblotting to ensure the hepatoprotective role of GK against NaAsO2 intoxication in mice. We found cotreatment with GK significantly attenuated NaAsO2-induced cell viability loss, intracellular ROS, and LDH release. Hepatic histopathology and serum biochemical parameters, ALT, and AST were notably improved by cotreatment with GK. Beside, GK markedly altered both mRNA and protein expression level of MAPK. The proapoptotic and antiapoptotic protein Bax/Bcl-2 ratio was significantly regulated by GK. Moreover, GK remarkably suppressed the postapoptotic transcription protein cleaved caspase-3 expression. The present study reveals that GK possesses hepatoprotective activity which is probably involved in the modulation of the MAPK/caspase-3 pathway.

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“…The dose and duration of arsenic treatment in vitro can be a critical factor in identifying targets of arsenic toxicity relevant to human exposures. A study found that chronic treatment in mice (8 wk) with high arsenite exposure (150 ppm) resulted in hepatic damage with observed tissue necrosis and significantly elevated serum glutamate-pyruvate transaminase (Noman et al 2015). HepG2 human hepatoma cells have been used as a model to study both the long-and short-term effects of arsenite on insulin signaling.…”

Section: Hepatic Glucose Metabolism and Insulin Signalingmentioning

confidence: 99%

“…The network analyses highlight genes involved in hepatic lipid metabolism and inflammation, such as SIRT1 and sterol regulatory element-binding protein (SREBP) ( Figure 5). The chemical's pronounced effects on liver function, hepatic steatosis, and injury have also been widely reported in murine models (Ditzel et al 2016;Shi et al 2014;Noman et al 2015). However, whether arsenic exposure modulates gluconeogenesis and glycogenolysis in vivo remains unexplored.…”

Section: )mentioning

confidence: 99%

A State-of-the-Science Review of Arsenic’s Effects on Glucose Homeostasis in Experimental Models

Castriota

Rieswijk

Dahlberg

et al. 2020

Environ Health Perspect

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BACKGROUND: The prevalence of type 2 diabetes (T2D) has more than doubled since 1980. Poor nutrition, sedentary lifestyle, and obesity are among the primary risk factors. While an estimated 70% of cases are attributed to excess adiposity, there is an increased interest in understanding the contribution of environmental agents to diabetes causation and severity. Arsenic is one of these environmental chemicals, with multiple epidemiology studies supporting its association with T2D. Despite extensive research, the molecular mechanism by which arsenic exerts its diabetogenic effects remains unclear. OBJECTIVES: We conducted a literature search focused on arsenite exposure in vivo and in vitro, using relevant end points to elucidate potential mechanisms of oral arsenic exposure and diabetes development. METHODS: We explored experimental results for potential mechanisms and elucidated the distinct effects that occur at high vs. low exposure. We also performed network analyses relying on publicly available data, which supported our key findings. RESULTS: While several mechanisms may be involved, our findings support that arsenite has effects on whole-body glucose homeostasis, insulinstimulated glucose uptake, glucose-stimulated insulin secretion, hepatic glucose metabolism, and both adipose and pancreatic b-cell dysfunction. DISCUSSION: This review applies state-of-the-science approaches to identify the current knowledge gaps in our understanding of arsenite on diabetes development.

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Arsenic-induced Histological Alterations in Various Organs of Mice

Cited by 16 publications

References 30 publications

Arsenic Status and Speciation in Chicken Heart Tissues

Arsenic Status and Speciation in Chicken Heart Tissues

In Vivo and In Vitro Hepatoprotective Effects of Geranium koreanum Methanolic Extract via Downregulation of MAPK/Caspase‐3 Pathway

A State-of-the-Science Review of Arsenic’s Effects on Glucose Homeostasis in Experimental Models

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