Arsenic toxicity and potential mechanisms of action

Hughes, Michael F.

doi:10.1016/s0378-4274(02)00084-x

Cited by 1,456 publications

(843 citation statements)

References 119 publications

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“…A 1000 mg·l −1 As AAS standard solution (Merck, Darmstadt, Germany) was used as iAs(V) stock standard solution. Stock solutions of 1000 mg·l −1 As were prepared for arsenic species iAs (III), MAs(V), DMAs(V) and TMAs(V)O in deionized water using following compounds: As 2 [32]. Working standards were prepared for individual species by serial dilution of stock solutions in deionized water.…”

Section: Standards and Reagentsmentioning

confidence: 99%

“…Tri-and pentavalent inorganic, mono-, di-and trimethylated arsenicals are products of animal and human metabolism of arsenic and are required to be determined even at ultra trace levels due to their high toxicity and mutagenic, teratogenic and carcinogenic effects [1][2][3][4]. Human metabolism of inorganic As (iAs) consists of reduction of pentavalent arsenicals and oxidative methylation of trivalent species that yields methylated arsenicals [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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On-line pre-reduction of pentavalent arsenicals by thioglycolic acid for speciation analysis by selective hydride generation–cryotrapping–atomic absorption spectrometry

Musil

Matoušek

2008

Spectrochimica Acta Part B: Atomic Spectroscopy

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An improvement of current method of selective hydride generation based on pre-reduction for differentiation of tri-and pentavalent arsenicals is described, applied for the oxidation state specific speciation analysis of inorganic, mono-, di-and trimethylated arsenicals with minimum sample pretreatment using atomic absorption spectrometry with the multiatomizer. The preconcentration and separation of arsine, methylarsine, dimethylarsine and trimethylarsine is then carried out by means of cryotrapping. Presented study shows that 2% (m/v) L-cysteine hydrochloride monohydrate (L-cys) currently used for off-line pre-reduction of pentavalent arsenicals can be substituted with 1% (m/v) thioglycolic acid (TGA). Much faster pre-reduction of pentavalent arsenicals at 25°C with equal sensitivities as in the case of L-cys has been achieved with TGA. A setup for on-line prereduction by TGA has been optimized, with the application of segmented flow analysis for suppression of axial dispersion in the pre-reduction coil. Standard calibrations measured with or without on-line pre-reduction indicate uniform and equal sensitivities for all As forms. The possibility of standardization by water standards of single species (e.g. iAs(III)) for quantification of all other As forms in urine is demonstrated in the recovery study. Limits of detection were 100 ng·l −1 for iAs (III), 135 ng·l −1 for iAs(V) and 30 to 50 ng·l −1 for methylated arsenicals.

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Section: Standards and Reagentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

On-line pre-reduction of pentavalent arsenicals by thioglycolic acid for speciation analysis by selective hydride generation–cryotrapping–atomic absorption spectrometry

Musil

Matoušek

2008

Spectrochimica Acta Part B: Atomic Spectroscopy

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“…Notably, some of these effects could be the consequence of a direct interaction of arsenic trioxide with GSH and protein thiols (Scott et al. 1993; Hughes 2002; Lu et al. 2007; Zhang et al.…”

Section: Introductionmentioning

confidence: 99%

Role of endoplasmic reticulum stress in drug‐induced toxicity

Foufelle

Fromenty

2016

Pharmacology Res & Perspec

194

161

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Drug‐induced toxicity is a key issue for public health because some side effects can be severe and life‐threatening. These adverse effects can also be a major concern for the pharmaceutical companies since significant toxicity can lead to the interruption of clinical trials, or the withdrawal of the incriminated drugs from the market. Recent studies suggested that endoplasmic reticulum (ER) stress could be an important event involved in drug liability, in addition to other key mechanisms such as mitochondrial dysfunction and oxidative stress. Indeed, drug‐induced ER stress could lead to several deleterious effects within cells and tissues including accumulation of lipids, cell death, cytolysis, and inflammation. After recalling important information regarding drug‐induced adverse reactions and ER stress in diverse pathophysiological situations, this review summarizes the main data pertaining to drug‐induced ER stress and its potential involvement in different adverse effects. Drugs presented in this review are for instance acetaminophen (APAP), arsenic trioxide and other anticancer drugs, diclofenac, and different antiretroviral compounds. We also included data on tunicamycin (an antibiotic not used in human medicine because of its toxicity) and thapsigargin (a toxic compound of the Mediterranean plant Thapsia garganica) since both molecules are commonly used as prototypical toxins to induce ER stress in cellular and animal models.

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“…Arsenic presence in water has been reported from several parts of the world, like USA, China, Chile, Bangladesh, Taiwan, Mexico, Argentina, Poland, Canada, Hungary, Japan, India, Vietnam, Nepal (Jain and Ali, 2000;Jack et al, 2003) and recently from Iran (Mosaferi et al, 2003). Inorganic As is considered to be the major form of As in groundwater, surface water, soil and various foods (Babel and Opiso, 2007) and have been classified as group I carcinogens based on human epidemiological data (Hughes, 2002). Millions of people have been exposed to arsenic contamination through drinking water.…”

Section: Introductionmentioning

confidence: 99%

Arsenic in soil, vegetation and water of a contaminated region

Zandsalimi

Karimi

Kohandel

2011

Int. J. Environ. Sci. Technol.

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Arsenic concentrations of surface waters, soils and plants were surveyed in three contaminated villages of Bijar County. Total arsenic in water samples (4.5 to 280 µg/L) was correlated with electrical conductivity, total dissolved solid, total hardness, alkalinity, chloride, sulphate, bicarbonate, calcium and sodium (p<0.001). Total arsenic in the soils ranged from 105.4 to 1500 mg/kg. Some of the soil factors play an important role in soil arsenic content and its bioavailability for organisms. In general, the arsenic concentrations in plants were low, especially in the most common wild species. Among 13 plant species, the highest mean arsenic concentration was found in leaves of Mentha Longifolia (79.4 mg/kg). Arsenic levels in soils and plants were positively correlated, while the ability of the plants to accumulate the element, expressed by their biological accumulation coefficients and arsenic transfer factors, was independent of the soil arsenic concentration. Relationships between the arsenic concentrations in plants, soils and surface water and the environmental aspects of these relationships have been discussed in comparison with literature data. The accumulation of arsenic in environmental samples (soil, sediment, water, plant, etc.) poses a potential risk to human health due to the transfer of this element in aquatic media, their uptake by plants and subsequent introduction into the food chain.

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Arsenic toxicity and potential mechanisms of action

Cited by 1,456 publications

References 119 publications

On-line pre-reduction of pentavalent arsenicals by thioglycolic acid for speciation analysis by selective hydride generation–cryotrapping–atomic absorption spectrometry

On-line pre-reduction of pentavalent arsenicals by thioglycolic acid for speciation analysis by selective hydride generation–cryotrapping–atomic absorption spectrometry

Role of endoplasmic reticulum stress in drug‐induced toxicity

Arsenic in soil, vegetation and water of a contaminated region

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