Artemisia Capillaris leaves inhibit cell proliferation and induce apoptosis in hepatocellular carcinoma

Kim, Ju‐Young; Jung, Kyung Hee; Zhang, Pengcheng; Cheon, Min Ji; Kang, Sa-Ouk; Jin, Xing; Park, Sunghyouk; Oh, Myung Sook; Hong, Soon‐Sun

doi:10.1186/s12906-018-2217-6

Cited by 28 publications

(11 citation statements)

References 41 publications

(39 reference statements)

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“…The TUNEL kit was purchased from Nanjing Jiancheng Bioengineering Institute (Nanjing, China; catalog no. G002–1‐2) and performed as described previously 27 . Cell apoptosis was evaluated by the proportion of TUNEL‐positive stained cells.…”

Section: Methodsmentioning

confidence: 99%

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miR‐211‐5p is down‐regulated and a prognostic marker in bladder cancer

Wang

Liu

Zhang

et al. 2020

The Journal of Gene Medicine

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Background: The micro RNA (miRNA)/histone deacetylase 9 (HDAC9) signaling axis has been reported to be involved in initiating and developing multiple malignant tumors. In the present study, we aimed to determine whether miR-211-5p serves as a post-transcriptional regulator in bladder cancer (BCa) cell proliferation and apoptosis by targeting HDAC9. Methods: miRNA expression profiling of BCa tissues and para-carcinoma tissues was screened by miRNA microarray. After transfection with miR-211-5p mimics or short hairpin RNA of HDAC9 (sh-HDAC9), mRNA and protein expression was evaluated using a quantitative reverse transcription-polymerase chain reaction and western blotting, respectively. A bioinformatics algorithm was used, and a dual-luciferase reporter assay was performed to validate HDAC9 as a direct target of miR-211-5p. Cell proliferation was analyzed by the 3-(4, 5-dimethylthiazl2-yl)-2,5diphenyltetazolium bromide (MTT) assay. Terminal deoxynucleotidyl transferasemediated dUTP nick-end labeling (TUNEL) detection was used to evaluate apoptosis in 5637 and T24 cells. A transwell assay was used to assess migration and invasion. Results: miR-211-5p is down-regulated in BCa tumor tissues and cell lines. miR-211-5p is identified as an independent biomarker for predicting overall survival. HDAC9 is a direct target of miR-211-5p, and overexpression of miR-211-5p represses HDAC9 protein expression in vitro. Overexpression of miR-211-5p or HDAC9 knockdown significantly inhibits proliferation, migration and invasion of 5637 and T24 cells, and also induces cell apoptosis. Conclusions: miR-211-5p may play a role as a tumor suppressor and as a favourable prognostic marker in BCa.

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Section: Methodsmentioning

confidence: 99%

“…G002-1-2) and performed as described previously. 27 Cell apoptosis was evaluated by the proportion of TUNEL-positive stained cells.…”

Section: Microarray Assaysmentioning

confidence: 99%

miR‐211‐5p is down‐regulated and a prognostic marker in bladder cancer

Wang

Liu

Zhang

et al. 2020

The Journal of Gene Medicine

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“…Link [Cm]) that possess anticancer properties. [11][12][13][14][15][16][17][18][19][20] FDY003 inhibits cancer cell proliferation and survival and induces apoptosis in cancer cells in vitro and in vivo. 21 FDY003 exerts therapeutic effects by modulating the activities of key regulators in the apoptotic signaling pathway, such as Bcl-2associated X protein (Bax) and caspase-3, in colorectal cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Systems Pharmacology Study of the Anticervical Cancer Mechanisms of FDY003

Lee¹,

Kang²,

Park³

et al. 2020

Natural Product Communications

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Increasing data support that herbal medicines are beneficial in the treatment of cervical cancer; however, their mechanisms of action remain to be elucidated. In the current study, we used a systems pharmacology approach to explore the pharmacological mechanisms of FDY003, an anticancer herbal formula comprising Lonicera japonica Thunberg, Artemisia capillaris Thunberg, and Cordyceps militaris (Linn.) Link, in the treatment of cervical cancer. Through the pharmacokinetic assessment of absorption-distribution-metabolism-excretion characteristics, we found 18 active compounds that might interact with 106 cervical cancer-related targets responsible for the pharmacological effects. FDY003 targets were significantly associated with gene ontology terms related to the regulation of cellular behaviors, including cell proliferation, cell cycle processes, cell migration, cell apoptosis, cell death, and angiogenesis. The therapeutic targets of the herbal drug were further enriched in various oncogenic pathways that are implicated in the tumorigenesis and progression of cervical cancer, including the phosphatidylinositol 3-kinase, mitogen-activated protein kinase, focal adhesion, human papillomavirus infection, and tumor necrosis factor signaling pathways. Our study provides a systematic approach to explore the anticancer properties of herbal medicines against cervical cancer.

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“…Ethyl acetate extract of A. capillaris can effectively inhibit the growth and induce apoptosis of hepatocellular carcinoma cells, and these effects are presumed to be mediated by inhibition of angiogenesis via the blockade of the PI3K/AKT/mTOR signaling pathway [27]. Dried leaves of A. capillaris use a similar mechanism to induce apoptosis in HepG2 and Huh7 cells and to suppress tumor growth in mouse xenograft models [28].…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris

et al. 2021

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Artemisia capillaris Thunb. (A. capillaris, Yin-Chen in Chinese) is a traditional medicinal herb with a wide spectrum of pharmacological properties ranging from effects against liver dysfunction to treatments of severe cirrhosis and cancer. We used relevant keywords to search electronic databases, including PubMed, Medline, and Google Scholar, for scientific contributions related to this medicinal herb and the pharmacokinetics of its components. The pharmaceutical effects of A. capillaris contribute to the treatment not only of viral hepatitis, cirrhosis, and hepatocellular hepatoma, but also metabolic syndrome, psoriasis, and enterovirus in the clinic. The bioactive compounds, including scoparone, capillarisin, scopoletin, and chlorogenic acid, exhibit antioxidant, anti-inflammatory, antisteatotic, antiviral, and antitumor properties, reflecting the pharmacological effects of A. capillaris. The pharmacokinetics of the main bioactive compounds in A. capillaris can achieve a maximum concentration within 1 hour, but only chlorogenic acid has a relatively long half-life. Regarding the use of the A. capillaris herb by health professionals to treat various diseases, the dosing schedule of this herb should be carefully considered to maximize therapeutic outcomes while lessening possible side effects.

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Artemisia Capillaris leaves inhibit cell proliferation and induce apoptosis in hepatocellular carcinoma

Cited by 28 publications

References 41 publications

miR‐211‐5p is down‐regulated and a prognostic marker in bladder cancer

miR‐211‐5p is down‐regulated and a prognostic marker in bladder cancer

Systems Pharmacology Study of the Anticervical Cancer Mechanisms of FDY003

The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris

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