Artemisia scoparia – A new source of artemisinin

Singh, Aditi; Sarin, Renu

doi:10.3329/bjp.v5i1.4901

Cited by 15 publications

(9 citation statements)

References 16 publications

(7 reference statements)

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“…Thus, our results support the view that ASHME may have some inhibitory influence on prostaglandin biosynthesis and/or release because prostaglandins are considered to be a major regulator of body temperature (Milton, 1982). Recently, Artemisia scoparia has been shown to have significant artemisinin content (Singh and Sarin, 2010). This finding and the antipyretic potential of ASHME also justify its use in the management of acute malaria as well as other infectious and inflammatory diseases.…”

Section: Discussionsupporting

confidence: 81%

Evaluation of anti-nociceptive, anti-inflammatory and antipyretic activities of Artemisia scoparia hydromethanolic extract

Habib

Waheed

2013

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 81%

Evaluation of anti-nociceptive, anti-inflammatory and antipyretic activities of Artemisia scoparia hydromethanolic extract

Habib

Waheed

2013

Journal of Ethnopharmacology

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“…1, is an unusual sesquiterpene lactone endoperoxide abundant in A. annua, to which the medicinal properties of this herb are attributed [8,11]. This compound has also been isolated from other Artemisia species such as A. scoparia [22]. Sesquiterpene lactones chemically related to artemisinin have also been identified from other Artemisia species.…”

Section: Sesquiterpene Lactones From Artemisia Genusmentioning

confidence: 93%

The Artemisia L. Genus

Martínez

Bedoya

Ticona

et al. 2012

Studies in Natural Products Chemistry

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“…Artemisinin ( Figure 1 ) is a cadinanolide with a 1,2,4-trioxane ring system, found most importantly in Artemisia annua L. and in minor quantities in A. apiaceae Hance and A. lancea Vaniot [ 20 ]. The presence of artemisinin in Artemisia sieberi and Artemisia scoparia in small quantities was also reported [ 21 , 22 ]. However, other bioactive compounds in Artemisia annua contribute to the overall activity of extracts: SLs arteannuin B and artemisitene, but also scopoletin and 1,8-cineole [ 23 ].…”

Section: Biological Activities Of Sesquiterpene Lactonesmentioning

confidence: 95%

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

Ivănescu

Miron

Corciovă

2015

Journal of Analytical Methods in Chemistry

155

118

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Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of Asteraceae family, with over 5000 structures reported to date. Within this family, genus Artemisia is very well represented, having approximately 500 species characterized by the presence of eudesmanolides and guaianolides, especially highly oxygenated ones, and rarely of germacranolides. Sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, antiulcer, antibacterial, antifungal, antiviral, antiparasitic, and insect deterrent. Many of the biological activities are attributed to the α-methylene-γ-lactone group in their molecule which reacts through a Michael-addition with free sulfhydryl or amino groups in proteins and alkylates them. Due to the fact that most sesquiterpene lactones are thermolabile, less volatile compounds, they present no specific chromophores in the molecule and are sensitive to acidic and basic mediums, and their identification and quantification represent a difficult task for the analyst. Another problematic aspect is represented by the complexity of vegetal samples, which may contain compounds that can interfere with the analysis. Therefore, this paper proposes an overview of the methods used for the identification and quantification of sesquiterpene lactones found in Artemisia genus, as well as the optimal conditions for their extraction and separation.

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Artemisia scoparia – A new source of artemisinin

Cited by 15 publications

References 16 publications

Evaluation of anti-nociceptive, anti-inflammatory and antipyretic activities of Artemisia scoparia hydromethanolic extract

Evaluation of anti-nociceptive, anti-inflammatory and antipyretic activities of Artemisia scoparia hydromethanolic extract

The Artemisia L. Genus

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

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