Artemisinin: A Potent Antimalarial Drug

Malaviya, Alok; Malhotra, Karan; Agarwal, Anil K.; Saikia, Katherine

doi:10.1002/9781119460053.ch15

Cited by 1 publication

(2 citation statements)

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“…Artemisinin a natural endoperoxide isolated from the plant Artemisia annua L , is widely used as an anti‐malaria drug and their derivatives have anti‐bacterial, anti‐inflammatory, and anti‐tumor activities [27–30] . Artemisinin exhibited greater activities than other antivirals, so it is known as the most effective drug in the treatment of malaria [43,44] . Semisynthetic derivatives of artemisinin, dihydroartemisinin, artesunate, and artemether have been developed with the aim of increasing the pharmacological activity and the pharmacokinetic profile of the main drug (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of Novel Artemisinin Derivatives and Their Electrochemical Properties

et al. 2022

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In present, new artemisinin-based organic compounds (1-6) are designed and synthesized in excellent yields (up to 97 %) via Steglich Esterification reactions. All new artemisinin derivatives are tested as anode catalysts for hydrazine electrooxidation reactions with electrochemical methods in 1 M KOH/ 0.5 M N 2 H 4 solution. Hybrid molecule 1 exhibits the best catalytic activity in hydrazine electrooxidation reaction with 2.28 mA cm À 2 value. Moreover, response surface methodology (RSM) is applied to investigate of optimum electrode conditions. By using optimum conditions, hydrazine electrooxidation is obtained as 3.55324 mA cm À 2 . As a result, artemisininbased hybrid compounds may be alternative, and nextgeneration anode catalyst for direct hydrazine fuel cells.

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Section: Introductionmentioning

confidence: 99%

“…[27][28][29][30] Artemisinin exhibited greater activities than other antivirals, so it is known as the most effective drug in the treatment of malaria. [43,44] Semisynthetic derivatives Table 1. Some examples for hydrazine electrooxidation in the literature.…”

Section: Introductionmentioning

confidence: 99%