Artemisinin-loaded niosome and pegylated niosome: physico-chemical characterization and effects on MCF-7 cell proliferation

Asgharkhani, Elnaz; Azarbayjani, Anahita Fathi; Irani, Shiva; Chiani, Mohsen; Saffari, Zahra; Norouzian, Dariush; Akbarzadeh, Azim; Atyabi, Seyed Mohammad

doi:10.1007/s40005-017-0331-y

Cited by 25 publications

(5 citation statements)

References 18 publications

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“…Physical stability tests (aggregation and leaching) at different storage conditions revealed that a high percentage of ODNs was retained in the nanocarrier system and low aggregation was observed after 60 days. At high temperature higher decoy ODN leakage and slightly larger aggregation was observed which was supported by a previous report …”

Section: Results and Discussionsupporting

confidence: 91%

“…At high temperature higher decoy ODN leakage and slightly larger aggregation was observed which was supported by a previous report. 51 The Behavior of Decoy ODNs Release and Kinetics. The release profiles of ODNs were investigated at 37 °C (human body temperature) using PBS in different pH media (7. controlled ODN release behavior was observed between 6 and 120 h, and a plateau phase was reached after 144 h (Table 2).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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NANOG Decoy Oligodeoxynucleotide–Encapsulated Niosomes Nanocarriers: A Promising Approach to Suppress the Metastatic Properties of U87 Human Glioblastoma Multiforme Cells

Gharbavi

Johari

Rismani

et al. 2020

ACS Chem. Neurosci.

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Recently, advances in the synthesis and development of multifunctional nanoparticle platforms have opened up great opportunities and advantages for specifically targeted delivery of genes of interest. BSA-coated niosome structures (NISM@B) can potentially improve the efficiency in vitro delivery of nucleic acid molecules and the transfection of genes. Few studies have reported the combined use of niosomes with nucleic acid as therapeutic agents or decoy oligodeoxynucleotides (ODNs). Herein, we synthesized NISM@B to encapsulate NANOG decoy ODN (NISM@B-DEC), after which the physicochemical characteristics and in vitro and in vivo properties of NISM@B-DEC were investigated. Our results regarding physicochemical characteristics revealed that the stable niosome nanocarrier system was successfully synthesized with a regular spherical shape and narrow size distribution with proper zeta-potential values and had an appropriate biocompatibility. The ODN release from the niosome nanocarrier system exhibited controlled and pH-dependent behavior as the best models to explain the ODN release profile. NISM@B-DEC was efficiently taken up by human glioblastoma cells (U87) and significantly inhibited cell growth. Finally, blockage of the NANOG pathway by NISM@B-DEC resulted in G1 cell cycle arrest, apoptosis, and cell death. In addition, NISM@B-DEC caused a significant decrease in tumor formation and improved wound-healing efficiency of the U87 cells. These findings confirm that NISM@B-DEC could potentially suppress the metastatic ability of these cells. It can be concluded that the presented nanocarrier system can be a promising approach for targeted gene delivery in cancer therapy.

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Section: Results and Discussionsupporting

confidence: 91%

Section: ■ Results and Discussionmentioning

confidence: 99%

NANOG Decoy Oligodeoxynucleotide–Encapsulated Niosomes Nanocarriers: A Promising Approach to Suppress the Metastatic Properties of U87 Human Glioblastoma Multiforme Cells

Gharbavi

Johari

Rismani

et al. 2020

ACS Chem. Neurosci.

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show abstract

“…The formulations may have exhibited sustained release due to the high phase transition temperature connected to Span 60. Previous researchers have reported on the same trend [ 33 , 34 , 35 ]. As the surfactant chain length extends, drug release can last longer because the transfer temperature can influence the surfactants and make them totally fluid, allowing for increased drug penetration at 37 °C [ 2 ].…”

Section: Resultssupporting

confidence: 72%

The effect of niosome preparation methods in encapsulating 5-fluorouracil and real time cell assay against HCT-116 colon cancer cell line

Ugorji¹,

Umeh²,

Agubata³

et al. 2022

Heliyon

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“…In this manner, the curcumin amount of the samples which were kept at 4 °C, was higher than the samples at 37 °C. The curcumin percentage which was retained at 4 °C, was between 68 and 77%, while the value would be decreased to 47% when the particles were incubated at 37 °C [ 83 ]. As a whole, the data showed that the nanoparticles stability decreased during the time and the temperature had a significant effect.…”

Section: Discussionmentioning

confidence: 99%

Polyethylene glycol triggers the anti-cancer impact of curcumin nanoparticles in sw-1736 thyroid cancer cells

Hosseinzadeh

Nazari

Esmaeili

et al. 2021

J Mater Sci: Mater Med

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Curcumin has been recognized as an effective anticancer agent. However, due to its hydrophobic property, the cell absorption is not satisfied. Herein, the curcumin nanoparticles were prepared in the presence of polyethylene glycol 6000 (PEG6000) to reduce its elimination by immune system. For first time, not only the curcumin was encapsulated within the niosome nanoparticles modified by PEG, there are no reports related to the anticancer property of curcumin against thyroid cancers. The nanoparticles was developed and its anticancer was studied on sw-1736 cancer cell line. The nanoparticles were examined by scanning electron microscopy (SEM) and dynamic light scattering (DLS). Also, the release profile of curcumin, the IC50 concentration, the radical amount and the gene expression were evaluated. The optimized nanoparticles showed a diameter of 212 ± 31 nm by SEM and the encapsulation efficiency and loading capacity of 76% and 16.8% respectively. DLS confirmed the polydispersity index (PDI) of 0.596 and the release model was shown a sustained release with the delivery of 68% curcumin after 6 days. Also, the nanoparticles indicated the higher storage stability at 4 °C. After the cell treatment, the apoptotic bodies were appeared and IC50 was obtained as 0.159 mM. Moreover, the generated radicals by the treated cells was 86% after 72 h and the gene pattern indicated the bax/bcl2 ratio of 6.83 confirming the apoptosis effect of the nanoparticles. The results approved the nanoparticles could be suggested as an anticancer drug candidate for thyroid cancers.

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Artemisinin-loaded niosome and pegylated niosome: physico-chemical characterization and effects on MCF-7 cell proliferation

Cited by 25 publications

References 18 publications

NANOG Decoy Oligodeoxynucleotide–Encapsulated Niosomes Nanocarriers: A Promising Approach to Suppress the Metastatic Properties of U87 Human Glioblastoma Multiforme Cells

NANOG Decoy Oligodeoxynucleotide–Encapsulated Niosomes Nanocarriers: A Promising Approach to Suppress the Metastatic Properties of U87 Human Glioblastoma Multiforme Cells

The effect of niosome preparation methods in encapsulating 5-fluorouracil and real time cell assay against HCT-116 colon cancer cell line

Polyethylene glycol triggers the anti-cancer impact of curcumin nanoparticles in sw-1736 thyroid cancer cells

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