Arterial aneurysms in Behçet’s disease patients: Frequency, clinical characteristics and long-term outcome

El-Ghobashy, Nehal; El-Garf, Kamal; Abdo, Marwa

doi:10.1016/j.ejr.2018.12.006

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…In conclusion, the experience with our patient presenting with life- and limb-threatening aneurysmal pathology, not all of which were amenable to endovascular intervention, supports the use of open surgery while ensuring that the patient obtains intensive immunosuppressive therapy to prevent postprocedural inflammatory changes, leading to adverse events such as anastomotic pseudoaneurysm 2 3 In addition, careful consideration should be given to the use of immunosuppressive therapy in conditions such as BD, when there is risk of infection with SARS-CoV-2 virus. Definitive guidelines are needed for the safe and effective treatment of these patients without altering their prognosis.…”

Section: Discussionmentioning

confidence: 57%

“…One of the main predictors of mortality and morbidity in BD is vascular involvement, which may occur in up to 40% of patients, depending on ethnicity. 2 4 Arterial aneurysms result from thrombosis of the vasa vasorum, causing cellular and arterial wall disruption and weakening. 5 Open surgical repair is dogged with anastomotic complications, which have significant consequences for life and limb.…”

Section: Discussionmentioning

confidence: 99%

“…Concomitant vasculitis may affect all vascular territories, leading to venous and arterial thrombosis and arterial aneurysms, with the latter most commonly affecting the pulmonary arteries (PA) and aorta. 2…”

mentioning

confidence: 99%

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Undiagnosed Behçet's Disease Complicated by Multiple Pseudoaneurysms and COVID-19 Infection

et al. 2021

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Behcet's disease (BD) is a rare multiorgan systemic disorder characterized by recurrent episodes of acute inflammation. Involvement of the vascular system, gastrointestinal tract, and central nervous system portends a poor prognosis.We report the case of a 54-year-old man who presented with a 2-week history of symptoms attributable to infrarenal aortic and left tibioperoneal trunk pseudoaneurysms, defined by CT angiography which also revealed right lower lobe pulmonary artery (PA) and right anterior tibial arterial aneurysms. A prior history of recurrent oral ulceration, periodic fever, cerebral venous sinus thrombosis, and aseptic endocarditis with pulmonary emboli invoked a diagnosis of BD. Immunosuppression was commenced immediately, following synchronous endovascular and open arterial intervention, except the PA aneurysm.He developed a fever and cough 8 days postoperatively as a consequence of COVID-19 infection from which he recovered without complications.The management of the patient's four aneurysms in different vascular territories and postoperative COVID-19 infection in the presence of mandatory immunosuppression are discussed.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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Undiagnosed Behçet's Disease Complicated by Multiple Pseudoaneurysms and COVID-19 Infection

et al. 2021

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“…Arterial involvement occurs in 3-8% of patients [ 11 ]. This incidence may be underestimated according to a Japanese autopsy case study which found 34% of arterial impairment in patients with BD [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

An Abdominal Aortic Pseudoaneurysm Revealing Behçet’s Disease

Baba

Mougui

Bouchti

2022

Case Reports in Vascular Medicine

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Behçet’s disease (BD) is a vasculitis with multisystemic manifestations. Articular involvement is frequent and benign whereas vascular complications are rare but serious and can form the onset of the disease. The assessment of the thickness of the common femoral vein wall is a new tool for the diagnosis of BD with good sensitivity and specificity. We report the case of a 52-year-old man diagnosed with BD revealed by an abdominal aortic pseudoaneurysm and a chronic monoarthritis. The first flare-up of BD can occur in men over 50 years of age. In a context of a multisystemic disease, lumbar pain should lead to the search of abdominal aortic aneurysm. The assessment of the thickness of the common femoral vein wall is accessible and should be used especially in challenging cases.

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“…It should be noted that the inappropriate use of anticoagulants in BD could be very dangerous especially in patients with pulmonary artery aneurisms because of the risk of vascular rupture. Arterial aneurysm is one of the most common vascular complications in BD the prevalence of which is about 25% [37,46,47]. Interestingly, aneurysms have been observed in patients with aPLs [48,49].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of antiphospholipid antibodies in Behçet's disease: A systematic review and meta-analysis

et al. 2020

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Behçet's disease (BD) is a multifactorial systemic inflammatory disease of unknown aetiology characterised by several clinical manifestations including vascular involvements (i.e., both arterial and venous thrombosis). Antiphospholipid antibodies (aPLs)-including anticardiolipin (aCL), anti-β2-glycoprotein I (β2-GPI) antibodies and lupus anticoagulant (LA) are detected in systemic autoimmune diseases which contribute to thrombosis. The aim of this systematic review and meta-analysis was to evaluate the prevalence of aPLs in patients with BD as compared to controls. A protocol was registered in PROSPERO (Registration No. CRD42018088125) and a systematic literature search was conducted through PubMed, Web of Science, Embase, Scopus and ScienceDirect databases. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random-effects model. Quality assessment was carried out by using the modified 9-star Newcastle-Ottawa Scale (NOS). Publication bias was evaluated via visualisation of contour-enhanced and trim and fill funnel plots along with Begg's and Egger's tests. We included ten case-control studies (a total of 999 participants from 380 BD patients and 619 controls) based on the inclusion criteria. The

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Arterial aneurysms in Behçet’s disease patients: Frequency, clinical characteristics and long-term outcome

Cited by 6 publications

References 35 publications

Undiagnosed Behçet's Disease Complicated by Multiple Pseudoaneurysms and COVID-19 Infection

Undiagnosed Behçet's Disease Complicated by Multiple Pseudoaneurysms and COVID-19 Infection

An Abdominal Aortic Pseudoaneurysm Revealing Behçet’s Disease

Prevalence of antiphospholipid antibodies in Behçet's disease: A systematic review and meta-analysis

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