Arterial injuries at the elbow carry a high risk of muscle necrosis and warrant urgent revascularisation

Lowrie, A G; Berry, M.G.; Kirkpatrick, James J.; Lees, Vivien C.; McGrouther, DA

doi:10.1308/003588412x13171221501429

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…The skeletal muscle ischemia-reperfusion (I/R) injury is a pathophysiological process during surgeries and post-surgical management in clinical practice, commonly seen in limb reattachment [1], limb vascular damage [2], osteofascial compartment syndrome [3][4][5], and free flap transplantation [6], which will directly affect the succeed of the operation especially in the division of orthopedics and the quality of life. It has well been accepted that skeletal muscle I/R injury is caused by free radicals produced from oxidative stress [7] and leukocytes play a key role in the pathogenesis of skeletal muscle I/R injury [8][9][10][11], which is preconditioned by the expression of adhesion molecular on leukocytes and endothelia [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Modeled Superoxide Dismutase Coordination Compound (MSODa) Against Ischemia/Reperfusion Injury in Rat Skeletal Muscle

Wang¹,

Tian²,

Xu³

et al. 2015

Cell Physiol Biochem

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Background/Aim: Ischemia/reperfusion (I/R) injury of skeletal muscles is common pathophysiology during surgeries and the superoxide dismutase (SOD) plays a critical role in this process. SOD-modeled coordination compound (MSODa) may simulate the protective effects as SOD. Methods: Therefore, this study was designed to explore the protective effects and underlying mechanism of MSODa on malondialdehyde (MDA) and integrin-β2 (CD11b/CD18) in plasma, myeloperoxidase (MPO) and intercellular cell adhesion molecule-1 (ICAM-1) in tissue, and morphological changes before and after I/R injury. The rat model of I/R in hind limb was established and randomly divided into sham, ischemia, I/R, I/R-treated with saline, SOD, and MSODa, respectively. Results: These results showed that averaged values for MDA, MPO, CD11b/CD18, and ICAM-1 were significantly increased (P < 0.01 vs ischemia alone) in a time-dependent fashion along with marked tissue remodeling, such as abnormal arrangement of muscular fibers, interstitial edema, vasodilation with no-reflow, inflammatory cells adherent and infiltration, structural changes in mitochondrial, and decrease in glycogens as well. However, all parameter changes induced by I/R injury were reversed, at least partially, by MSODa and SOD treatments and intriguingly, the beneficial/protective effects of MSODa was superior to SOD with an early onset. Conclusion: This novel finding demonstrates that MSODa improves I/R injury of skeletal muscles due at least partially to inhibition of adherent molecule expression and reduction of oxygen free radical formation during I/R pathophysiological processes and this protective action of MSODa was superior to SOD, highlighting the bright future for MSODa in clinical management of tissue I/R injury.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Modeled Superoxide Dismutase Coordination Compound (MSODa) Against Ischemia/Reperfusion Injury in Rat Skeletal Muscle

Wang¹,

Tian²,

Xu³

et al. 2015

Cell Physiol Biochem

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“…[11] Surgical techniques for primary repair include ligation, approximation (end-to-end anastomosis), and primary suturing, while techniques for secondary repair include graft interposition (either autologous or prosthetic) and patch plasty. [6] Secondary repair to the radial artery and primary repair to the ulnar artery were performed in the present case. Under more typical circumstances, the radial artery could have been ligated or reconstructed using an autologous graft from the saphenous or cephalic veins, rather than that of an ulnar artery segment.…”

Section: Discussionmentioning

confidence: 88%

“…[5] Distal pulses are palpable in 25% of brachial artery injuries and 50% of isolated radial or ulnar artery injuries, due to flow via collateral circulation. [6] Thus, detailed inspection of the injury site and evaluation of arterial currents with Duplex ultrasound (DUS) are essential for precise diagnosis. [5] Described in the present report is a different approach to surgical treatment in the rare circumstance that both the radial and ulnar arteries were injured.…”

Section: Introductionmentioning

confidence: 99%

A Different Approach to the Simultaneously Injured Ulnar and Radial Arteries: Translocation of an Arterial Segment

Başbuğ

Bitargil

Özışık

2015

Ulus Travma Acil Cerrahi Derg

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“…Every effort should be made to optimize repair technique. Fully viable muscle is necessary to restore function and livelihoods [35]. Many factors affect regeneration following IRI, as increased vascular endothelial growth factor production which significantly increased the capillary bed and promoted regeneration [36].…”

Section: Morphometric Resultsmentioning

confidence: 99%

Effect of Exercise Training on Endogenous Stem Cells Activation in Ischemia Reperfusion Induced Skeletal Muscle Injury: A Physio- Histological Study

Youssef¹

2015

J Cytol Histol

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Background: This study aimed at investigating the possible role of exercise training in activating the migration of CD34 positive progenitor cells in a rat model of induced ischemia reperfusion injury (IRI) of limb skeletal muscle and related regeneration potential. Material and methods: 28 adult male albino rats were divided into three groups: group I: control group; group II: IRI with 2 hours ischemia and 2 hours reperfusion, followed by immediate sacrifice (subgroup IIa) or delayed sacrifice after two weeks (subgroup IIb); group III: exercise in the form of group and gradual swimming for 4 weeks, followed by IRI and immediate sacrifice (subgroup IIIa), or delayed sacrifice (subgroup IIIb). Muscle performance was evaluated by physiological tests. Histological study was done using H&E staining, and immunohistochemical staining using anti αSMA and anti CD34. Areas of regenerating fibers, area of αSMA and area percentage of CD34 were measured. Statistical analysis was performed. Results: IRI group showed severe muscle damage in IIa in the form of wavy, disrupted darkly acidophilic fibers, many dark nuclei, and extravasated blood. There was some improvement in IIb in the form of regenerating fibres with central nuclei and increased αSMA and CD34 immunostaining. Group III showed better preservation of muscle fibers in IIIa. It also showed significant increase in area of regenerating fibers and statistically significant increase in area of αSMA and CD34 and in physiological parameters in IIIb as compared to group II. Conclusion: Exercise training prior to skeletal muscle IRI markedly improved muscle outcome through preservation and regeneration. Two populations of skeletal muscle stem cells, namely progenitor cells and satellite cells were involved in the process.

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Arterial injuries at the elbow carry a high risk of muscle necrosis and warrant urgent revascularisation

Cited by 4 publications

References 15 publications

Protective Effects of Modeled Superoxide Dismutase Coordination Compound (MSODa) Against Ischemia/Reperfusion Injury in Rat Skeletal Muscle

Protective Effects of Modeled Superoxide Dismutase Coordination Compound (MSODa) Against Ischemia/Reperfusion Injury in Rat Skeletal Muscle

A Different Approach to the Simultaneously Injured Ulnar and Radial Arteries: Translocation of an Arterial Segment

Effect of Exercise Training on Endogenous Stem Cells Activation in Ischemia Reperfusion Induced Skeletal Muscle Injury: A Physio- Histological Study

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