Arterial Plasma Epinephrine Concentrations and Hemodynamic Responses After Dental Injection of Local Anesthetic with Epinephrine

Tolas, Andrew G.; Pflug, A. Eugene; Halter, Jeffrey B.

doi:10.14219/jada.archive.1982.0114

Cited by 92 publications

(51 citation statements)

References 6 publications

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“…Despite the fact that epinephrine is a vasoconstrictor its entry into the circulation following intra-oral injection occurs early in the post-injection period. 7 Biochemical changes attributable to exogenous epinephrine are apparent 10 minutes following intra-oral anaesthesia in adults. 4,5 Studies of blood pressure and heart rate in adult volunteers and in adult patients undergoing oral surgery with the same local anaesthetics used in this investigation have shown no differences in the changes in systolic blood pressure and heart rate but a decrease in diastolic blood pressure following injection of the epinephrinecontaining solution.…”

Section: Discussionmentioning

confidence: 99%

The influence of two different dental local anaesthetic solutions on the haemo-dynamic responses of children undergoing restorative dentistry: a randomised, single-blind, split-mouth study

2001

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Section: Discussionmentioning

confidence: 99%

The influence of two different dental local anaesthetic solutions on the haemo-dynamic responses of children undergoing restorative dentistry: a randomised, single-blind, split-mouth study

2001

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“…Some authors are against this usage of epinephrine advocating that there is a high risk of systemic absorption, which may cause unwanted cardiovascular effects [7]. However epinephrine used in these solutions are relatively lower in dosage and are shown not to have significant effects on blood pressure and heart rate compared to the secretion of high levels of endogenous epinephrine during an anxiety-inducing conditions [6].…”

Section: Introductionmentioning

confidence: 99%

Does Third Molar Surgery Alter Cardiac Parameters? A Retrospective Study

Sindel

Altay

Yıldırımyan

et al. 2017

Pesqui. bras. odontopediatria clín. integr.

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Objective: To investigate perioperative changes in the cardiac parameters of anxiety, which are blood pressure and heart rate, in patients undergoing surgical extraction of third molars. Material and Methods: Patients who reported anxiety before scheduled procedures were monitored for cardiac parameters before, during and after the surgery. The obtained data were analyzed to determine if there is a certain pattern of change within these values in systemically healthy patients. Alterations in selected parameters with regard to duration and difficulty of operation were also studied. IBM SPSS Statistics was used for data analysis. Repeated-measures of analysis of variance (ANOVA), paired samples t-test and Kruskal-Wallis tests were applied and a significance level of 5% was assessed. Results: Difficulty was categorized as minimally, moderately or very difficult in 9, 28 and 3 patients respectively. Mean operation time was 36.18 minutes with a range of 8 to 91 minutes. Operation time showed no variations with different levels of difficulty (p = 0.268). No statistical differences in any of the parameters listed above could be identified. Conclusion: Despite the common belief that dental procedures initiate anxiety, this study reveals that physiological parameters of anxiety show no significant changes over the course of third molar surgery, likewise difficulty and duration of surgery do not cause noteworthy changes in these parameters.

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“…It has been shown that adrenaline-containing dental local anesthetics, when injected in clinical doses, raise blood glucose concentrations in healthy volunteers [5,6]. When the metabolic effects of adrenaline-containing and adrenaline-free local anaesthetics were investigated in unsedated patients having third molar surgery, differences between treatments were found in the changes from baseline plasma blood glucose concentrations [7,8]. This could have consequences in the diabetic patient.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Haemodynamic and Metabolic Effects of Local Anaesthetic Agent in Routine Dental Extractions

Akinmoladun

Okoje

Akinosun

et al. 2012

J. Maxillofac. Oral Surg.

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Introduction The systemic effects of adrenaline administered during dental local anesthesia have been the subject of many studies. The purpose of this study was to investigate the haemodynamic and metabolic effects attributable to adrenaline injected during local anesthesia in dental extraction patients. Methods Apparently medically fit patients were included and randomized into two groups. Participants had breakfast before coming in for tooth extraction. The weight, height, blood pressure and pulse rate were measured and blood sample taken before administration of local anaesthetic injections. Blood pressure, pulse and blood sample were again taken at 15 and 30 min. Results While the adrenaline group showed a modest increase between pre-and post-drug administration states, the control group showed no difference in median systolic blood pressures. Both groups showed a slight increase in diastolic blood pressure observed between pre-and postdrug administration states. Also both groups showed no significant difference in median pulse rate throughout. Although blood glucose values were widely dispersed in the pre-drug administration state in both groups, the control group showed no difference in median values throughout. However, a modest increase was observed in the adrenaline group between pre-and post-drug administration states, which persisted beyond 30 min. Conclusion The patients treated with local anesthesia with adrenaline showed a response similar to that observed in the control group.

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Arterial Plasma Epinephrine Concentrations and Hemodynamic Responses After Dental Injection of Local Anesthetic with Epinephrine

Cited by 92 publications

References 6 publications

The influence of two different dental local anaesthetic solutions on the haemo-dynamic responses of children undergoing restorative dentistry: a randomised, single-blind, split-mouth study

The influence of two different dental local anaesthetic solutions on the haemo-dynamic responses of children undergoing restorative dentistry: a randomised, single-blind, split-mouth study

Does Third Molar Surgery Alter Cardiac Parameters? A Retrospective Study

Evaluation of the Haemodynamic and Metabolic Effects of Local Anaesthetic Agent in Routine Dental Extractions

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