Goal. To reveal the peculiarities of central hemodynamics of cadets of a marine university in the conditions of a five-month sailing.Materials and methods. A survey of 70 cadets on board of a sailing training vessel was carried out in the dynamics of a five-month voyage (165 days). Hemodynamic indicators were monitored before entry on duty. For the statistical processing of the results, the SPSS software, v 17.0 (IBM) was used.Results and its discussion. The first two months are characterized by stable indicators of myocardial contractile function, which begins to change from the third month. In the third month, signs of mobilization of the circulatory function appear, which is expressed in an increase in blood pressure (p<0.05) and blood pressure (p<0,05) (by 6.6% and 14%, respectively).The fourth and fifth months are characterized by a further activation of the compensatory-adaptive mechanisms of hemodynamics: an increase in blood pressure (p<0,05), blood pressure (p<0,001), as well as MVC (p<0,05) due to an increase in heart rate (p<0,001), which indirectly indicates a decrease in efficiency in the work of the cardiovascular system.