Arterial Stenting and Overdilation: Does it Change Wall Mechanics in Small-Caliber Arteries?

Vernhet, Hélène; Demaria, Roland; Juan, Jean-Marie; Oliva-Lauraire, Marie-Claire; Sénac, J. P.; Dauzat, M.

doi:10.1177/152660280200900620

Cited by 7 publications

(7 citation statements)

References 39 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MVP reproduces the mechanical conditions of lower cyclic strain amplitude within a stent in vivo [46]. The expression of inactive pGSK-3β and Notch1 was examined 7 days following implantation of a BMS.…”

Section: Resultsmentioning

confidence: 99%

“…The stented MVP fully reproduces the mechanical microenvironment within a stent and mimics the significant decrease in arterial wall compliance and distensibility following stent implantation [46]. A decrease in cyclic strain amplitude within the stent resulted in a marked increase in vSMC cell growth concomitant with an increase in GSK-3β activation and enhanced Notch1 signaling.…”

Section: Discussionmentioning

confidence: 99%

“…Pathological changes in vessel structure are induced, in part, by changes in the biomechanical environment and burden on vSMC and the subsequent activation of discrete signaling pathways that govern growth where reduced cyclic strain/tension can result in substantial changes in vSMC proliferation and apoptosis [16, 46]. The Notch signaling pathway is a highly conserved developmental pathway that controls cell differentiation during embryonic development of the vasculature and is recapitulated in adult cells following vascular injury [36].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival

et al. 2011

View full text Add to dashboard Cite

The role of glycogen synthase kinase 3 beta (GSK-3β) in modulating Notch control of vascular smooth muscle cell (vSMC) growth (proliferation and apoptosis) was examined in vitro under varying conditions of cyclic strain and validated in vivo following changes in medial tension and stress. Modulation of GSK-3β in vSMC following ectopic expression of constitutively active GSK-3β, siRNA knockdown and pharmacological inhibition with SB-216763 demonstrated that GSK-3β positively regulates Notch intracellular domain expression, CBF-1/RBP-Jκ transactivation and downstream target gene mRNA levels, while concomitantly promoting vSMC proliferation and inhibiting apoptosis. In contrast, inhibition of GSK-3β attenuated Notch signaling and decreased vSMC proliferation and survival. Exposure of vSMC to cyclic strain environments in vitro using both a Flexercell™ Tension system and a novel Sylgard™ phantom vessel following bare metal stent implantation revealed that cyclic strain inhibits GSK-3β activity independent of p42/p44 MAPK and p38 activation concomitant with reduced Notch signaling and decreased vSMC proliferation and survival. Exposure of vSMC to changes in medial strain microenvironments in vivo following carotid artery ligation revealed that enhanced GSK-3β activity was predominantly localized to medial and neointimal vSMC concomitant with increased Notch signaling, proliferating nuclear antigen and decreased Bax expression, respectively, as vascular remodeling progressed. GSK-3β is an important modulator of Notch signaling leading to altered vSMC cell growth where low strain/tension microenvironments prevail.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival

et al. 2011

View full text Add to dashboard Cite

show abstract

“…The trauma of this procedure is often exacerbated by the inability of the balloon to expand the stent fully to its nominal size. This requires a second dilation of the balloon called postdilation, which leads to the overexpansion of the blood vessel wall [6][7][8]. Second, inadequate stent deployment is likely to alter the blood flow conditions increasing the risk of reduced laminary flow and increased pressure gradients.…”

Section: Stents In Percutaneous Transluminal Coronary Angioplastymentioning

confidence: 99%

Interfacial biology of in-stent restenosis

Santin¹,

Colombo²,

Bruschi³

2005

Expert Review of Medical Devices

View full text Add to dashboard Cite

Percutaneous angioplasty is a nonsurgical method able to restore patency in atherosclerotic blood vessels through the expansion of a balloon. The clinical outcome of this technique has been significantly enhanced by the combined deployment of a stent. Although stents are successful in the majority of cases, a large percentage of patients (20-30%) still suffer a second vessel lumen reduction known as in-stent restenosis. In-stent restenosis is recognized to be caused by the mechanical and foreign body challenges elicited by the device. Drug-eluting stents have been recently made available to tackle restenosis, but their short clinical history and high costs may limit their future use. The present review links the most recent biologic findings related to in-stent restenosis to the devices' phyisico-chemical features in an attempt to demonstrate that a new generation of stents may be developed without the need of drug elution.

show abstract

“…According to the authors, spasm caused by overdilation may be responsible for the decrease in compliance and distensibility measurements distal to the stent. 20 The use of aortic stents has also been found to have a significant effect on the blood supply of the media at the stented segment, which is responsible of an acute decrease in the aortic coefficient of distensibility. 21,22 In vitro models have also shown that endografting of aortic aneurysms results in loss of laminar flow, with propagating vortices along the length of the stented segment.…”

Section: ¤ ¤mentioning

confidence: 99%

Changes in Coronary Flow Reserve following Stent Implantation in the Swine Descending Thoracic Aorta

Zacharoulis¹,

Arapi²,

Lazaros³

et al. 2007

J Endovasc Ther

View full text Add to dashboard Cite

show abstract

Arterial Stenting and Overdilation: Does it Change Wall Mechanics in Small-Caliber Arteries?

Abstract: Endovascular stenting of the rabbit aorta produces a significant decrease in arterial wall compliance and distensibility. Stent overdilation is responsible for a slight additional decrease of compliance downstream from the stent.

Cited by 7 publications

References 39 publications

Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival

Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival

Interfacial biology of in-stent restenosis

Changes in Coronary Flow Reserve following Stent Implantation in the Swine Descending Thoracic Aorta

Contact Info

Product

Resources

About