Arterial stiffness in metabolic syndrome

Adel, Mona; Elsheikh, A. Haj; Sameer, Sameh; Haseeb, Waiel; Elsheikh, Eman; Kheder, Lamia

doi:10.1016/j.jsha.2015.12.005

Cited by 7 publications

(6 citation statements)

References 40 publications

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“…22 determine the arterial stiffness of many diseases such as HT, coronary artery disease, DM, and metabolic syndrome. 6,7,24,25 In our study, we investigated the relationship between AVP and TOD, and the predictive value on LVH and proteinuria. To the best of our knowledge, there is no study investigating the predictive value of the novel echocardiographic method APV on target organ damages LVH and proteinuria.…”

Section: Discussionmentioning

confidence: 99%

Aortic‐flow propagation velocity is associated with proteinuria and left ventricular hypertrophy in newly diagnosed hypertensive patients

et al. 2019

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Objective Subclinical target organ damage (TOD) is an important long‐term complication of hypertension and is associated with cardiovascular events and death. Aortic‐flow propagation velocity (APV) is one of the arterial stiffness parameters. The aim of this study was to investigate the predictive value of APV on left ventricular hypertrophy (LVH) and proteinuria. Methods A total of 149 newly diagnosed HT patients were included in the study. Urine samples and blood tests were obtained from each patient for diagnosis of proteinuria. All patients underwent echocardiographic examination. All patients’ APV measurements, carotid intima‐media thicknesses (CIMT), and ankle‐brachial indexes (ABI) were measured and recorded. Results The LVH (+) group consisted of 47 patients, and the LVH (−) group consisted of 102 patients. The proteinuria (+) group consisted of 32 patients, and the proteinuria (−) group consisted of 117 patients. Average CIMT was significantly higher in both proteinuria (+) and LVH (+) groups compared with the (−) groups. ABI and APV were significantly lower in both proteinuria (+) and LVH (+) groups compared with the (−) groups. APV was negatively correlated with LVH, proteinuria, and CIMT and positively correlated with ABI. In the multivariate binary logistic regression analysis, APV was the significant independent predictor of proteinuria. Additionally, APV and ABI were found to be independent predictors of LVH or/and proteinuria. Conclusion Hypertensive patients who had TOD had worse consequences of APV, CIMT, and ABI. APV had a powerful predictive value to identify the patients with higher risk of TOD among newly diagnosed hypertensive patients.

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Section: Discussionmentioning

confidence: 99%

Aortic‐flow propagation velocity is associated with proteinuria and left ventricular hypertrophy in newly diagnosed hypertensive patients

et al. 2019

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“…The level of CRP has been associated with indices of arterial function in several populations ( 7 , 17 , 21 , 80 , 97 – 100 ). However, data regarding a possible direct etiological role of CRP in arterial dysfunction and atherosclerosis are contradictory, and there are also studies reporting no significant relationship between PWV and hsCRP ( 17 , 101 ).…”

Section: Crp High-sensitivity C-reactive Protein (Hscrp) and Arterimentioning

confidence: 99%

“…A significant correlation was reported between aortic flow propagation velocity (AVP), which is a parameter of reduced arterial stiffness, assessed by transthoracic echocardiography, and high CRP levels, which is indicating a link between aortic stiffness and inflammation ( 7 ). Several other cross-sectional studies demonstrated the link between metabolic syndrome, arterial stiffness, and inflammation ( 97 ).…”

Section: Crp High-sensitivity C-reactive Protein (Hscrp) and Arterimentioning

confidence: 99%

“…C-reactive protein and hsCRP were associated with arterial stiffness in patients with metabolic syndrome, renal transplant, diabetes mellitus, and RA (Table 4 ) ( 7 , 21 , 102 , 104 ). Many interventions able to reduce cardiovascular risk have been associated with lower hsCRP values, such as weight loss, diet, exercise, smoking cessation, use of lipid-lowering drugs (statins, niacin, fibrates, gemfibrozil), aspirin, and thiazolidinediones ( 92 ).…”

Section: Crp High-sensitivity C-reactive Protein (Hscrp) and Arterimentioning

confidence: 99%

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Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases

Malainer²,

et al. 2017

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Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matrix degradation, oxidative stress, elastolysis, and degradation of collagen. The present paper reviews main mechanisms explaining the crosstalk between inflammation and arterial stiffness and the most common inflammatory markers associated with increased arterial stiffness, considering the most recent clinical and experimental studies. Diverse studies revealed significant correlations between the severity of arterial stiffness and inflammatory markers, such as white blood cell count, neutrophil/lymphocyte ratio, adhesion molecules, fibrinogen, C-reactive protein, cytokines, microRNAs, and cyclooxygenase-2, in patients with a broad variety of diseases, such as metabolic syndrome, diabetes, coronary heart disease, peripheral arterial disease, malignant and rheumatic disorders, polycystic kidney disease, renal transplant, familial Mediterranean fever, and oral infections, and in women with preeclampsia or after menopause. There is strong evidence that inflammation plays an important and, at least, partly reversible role in the development of arterial stiffness, and inflammatory markers may be useful additional tools in the assessment of the cardiovascular risk in clinical practice. Combined assessment of arterial stiffness and inflammatory markers may improve non-invasive assessment of cardiovascular risk, enabling selection of high-risk patients for prophylactic treatment or more regular medical examination. Development of future destiffening therapies may target pro-inflammatory mechanisms.

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“…Вместе с тем, органопротекция остается важным аспектом при лечении артериальной гипертензии (АГ). В последнее время все большую значимость приобретает необходимость коррекции центрального АД, улучшения эластичности сосудов и влияния на так называемые "новые" факторы риска (С-реактивный белок (СРБ), гомоцистеин, лептин и адипонектин) [2][3][4][5]. Выявлены существенные различия между классами антигипертензивных препаратов и их отдельными представителями по влиянию на показатели эластичности сосудов различного калибра [6][7][8][9][10][11][12][13].…”

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ADDITIONAL ANGIOPROTECTION AND METAbOLIC DISORDERS CORRECTION IN TREATMENT OF ARTERIAL HYPERTENSION PATIENTS REACHED TARGET bLOOD PRESSURE LEVELS, WITH FIxED COMbINATION OF PERINDOPRIL AND INDAPAMIDE

et al. 2018

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Aim. Evaluation of the ability of fixed combination of perindopril and indapamide (Noliprel Bi Forte) to achieve additional angioprotection in patients with arterial hypertension already reached target blood pressure (BP) at previous antihypertension therapy with losartan and hydrochlorothiazide (HCT).Material and methods. To open observational study, lasting 12 weeks, 25 patients included, those who had been taking losartan+HCT 100/12,5 mg. Results. During the study, all patients underwent 24 hour BP monitoring, applanation tonometry (augmentation index assessment and of central BP), measurement of pulse wave velocity (PWV), laboratory tests (lipids, fasting glucose, HOMA index, homocystein, leptin, adiponectin, high-sensitive C-reactive protein (hsCRP), vascular age assessment). After shifting the therapy with losartan and HCT to combination perindopril and indapamide, BP decreased additionally by 3,9%, and diastolic BP — 5,4% (p<0,05). There was decrease of augmentation index by 9,4% and vascular age by 6,0% (p<0,05). There was also decrease of leptin level by 14,5%, hsCRP by 11,0%, and increase of adiponectin by 9,9% (p<0,05).Conclusion. The fixed combination perindopril and indapamide does have advantages for losartan and HCT combination in BP control, vascular elasticity improvement, and facilitates the decrease of body mass index, insulin resistance and non-infectious inflammation.

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Arterial stiffness in metabolic syndrome

Abstract: Transthoracic echocardiographic determination of AVP is a simple practical method and correlates well with FMD in patients with MS.

Cited by 7 publications

References 40 publications

Aortic‐flow propagation velocity is associated with proteinuria and left ventricular hypertrophy in newly diagnosed hypertensive patients

Aortic‐flow propagation velocity is associated with proteinuria and left ventricular hypertrophy in newly diagnosed hypertensive patients

Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases

ADDITIONAL ANGIOPROTECTION AND METAbOLIC DISORDERS CORRECTION IN TREATMENT OF ARTERIAL HYPERTENSION PATIENTS REACHED TARGET bLOOD PRESSURE LEVELS, WITH FIxED COMbINATION OF PERINDOPRIL AND INDAPAMIDE

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