Arterial supply of the trigeminal ganglion, a micromorphological study

Ćetković, Mila; Štimec, Bojan; Mucić, Dinka; Dožić, A; Ćetković, Dejan; Reçi, Valvita; Çerkezi, Selim; Ćalasan, Dejan; Milisavljevic, Мilan; Bexheti, Sadi

doi:10.5603/fm.a2019.0062

Cited by 5 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies [2,8] have described the blood supply of the TN and TG, the different origins and the external distribution of the trigeminal branches. What remains unknown is the precise internal vascular pattern of TG microcirculation [9].…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical analysis of the arterial supply and mast cells of the trigeminal ganglion

Lj.

Malikovic

Stimec

et al. 2021

ARCH BIOL SCI BELGRA

View full text Add to dashboard Cite

The aim of this study was to quantify the distribution of microvessels and mast cells in all three parts of the trigeminal ganglion (TG). Statistical analyses were applied to investigate possible micromorphological regional differences in their density. Five serially sectioned human TGs were prepared for CD34 and mast cell tryptase immunostaining. The following quantifications were performed in microscopic fields of three parts of the TG: microvessel density (MVD), mast cell density (MCD) and ganglionic cell count. The density of CD34-positive microvessels was not significantly different in any of the three observed parts of the TG. The distribution of neurons showed no significant statistical difference in three parts of the TG. There was no difference in the density of tryptase-positive mast cells within the TG, but there was an abundant presence of mast cells in the periganglionic dural and subdural tissues, a finding hitherto not reported. We can say that there is a homogenous vascular pattern within the TG which excludes local predominance in pathogenesis of trigeminal neuralgia. Second, and more important, the finding of peri-trigeminal mast cells indicates their important role in migraine pain and confirms their degranulation as the main therapeutic goal for this condition.

show abstract

Section: Introductionmentioning

confidence: 99%

Immunohistochemical analysis of the arterial supply and mast cells of the trigeminal ganglion

Lj.

Malikovic

Stimec

et al. 2021

ARCH BIOL SCI BELGRA

View full text Add to dashboard Cite

show abstract

“…From here, the product most likely migrated into the middle meningeal artery (Figure 6) which transitioned from extra‐cranial to intra‐cranial via the foramen spinosum and provides arterial blood supply to the trigeminal ganglion which is located in Meckle's cave within the middle cranial fossa 5,6 . The product seemed to have resulted in an obstruction of the arterial vascular supply of the left‐sided trigeminal ganglion 2,7,8 . The absence of arterial vascular supply most likely resulted in the loss of function of the sensory‐afferent cells located in the ganglion.…”

Section: Discussionmentioning

confidence: 98%

“…Additional arterial blood supply can originate from direct branches of the maxillary artery and its deep temporal branches. While the zygomatico‐facial artery is positioned within the internal carotid artery vascular territory, the majority of the branches supplying the deep soft tissue plane of the zygomatic arch belongs to the external carotid artery vascular territory 1‐4 …”

Section: Discussionmentioning

confidence: 99%

“…The injection location receives arterial vascular supply by trans- territory. [1][2][3][4] It seems most likely that the injected product gained access to the arterial vascular system via the trans-zygomatic branches and was transported to the maxillary artery. From here, the product most likely migrated into the middle meningeal artery (Figure 6) which transitioned from extra-cranial to intra-cranial via the foramen spinosum and provides arterial blood supply to the trigeminal ganglion which is located in Meckle's cave within the middle cranial fossa.…”

Section: Vascular Pathway (Most Probable)mentioning

confidence: 99%

“…5,6 The product seemed to have resulted in an obstruction of the arterial vascular supply of the left-sided trigeminal ganglion. 2,7,8 The absence of arterial vascular supply most likely resulted in the loss of function of the sensory-afferent cells located in the ganglion. Additionally, it seems most likely that in the initial phase after the vascular obstruction the transitioning efferent motor fibers were likewise affected (the motor cells for those fibers are located in the motor nucleus of the trigeminal nerve in the pons and do not synapse in the ganglion).…”

Section: Vascular Pathway (Most Probable)mentioning

confidence: 99%

See 2 more Smart Citations

Acute isolated trigeminal neuropathy following calcium hydroxylapatite‐based soft tissue filler injection: A case report

Мингазова

Karpova²,

Murakov³

et al. 2021

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

Ultrasound localization microscopy and functional ultrasound reveal atypical features of the live trigeminal ganglion

Goazigo

Beliard

Rahal

et al. 2021

Preprint

View full text Add to dashboard Cite

The functional imaging of the neurovascular coupling within the trigeminal ganglion (TG) is highly challenging due to its small size and its deep localization. This study combined a methodological framework able to dive into the rat trigeminal nociceptive system by jointly providing first imaging of the trigeminal ganglion blood vasculature at microscopic resolution and the measurement of its neurovascular coupling in the rat TG evoked by corneal stimulations, a robust and clinically-relevant model. Using functional ultrasound imaging (fUS), we were able to image and quantify a strong hemodynamic response in the ipsilateral TG from anesthetized rats, evoked by mechanical or chemical stimulations of corneal nociceptive fibers to intact cornea, even though TG involves less than 300 sensory neurons. The in vivo quantitative imaging of the TG’s vasculature using ultrasound localization microscopy (ULM) combined with ex-vivo (DiI) staining reveals particular features of the vascularization of the area containing the sensory neurons, that is likely the origin of this strong vaso-trigeminal response and due to the nature of this structure at the interface between the peripheral and central nervous systems. This innovative imaging approach opens the path for future studies on the mechanisms underlying changes in trigeminal local blood flow and neurovascular coupling, key mechanisms and readouts for the understanding and treatment of debilitating trigeminal pain conditions.

show abstract

Arterial supply of the trigeminal ganglion, a micromorphological study

Cited by 5 publications

References 0 publications

Immunohistochemical analysis of the arterial supply and mast cells of the trigeminal ganglion

Immunohistochemical analysis of the arterial supply and mast cells of the trigeminal ganglion

Acute isolated trigeminal neuropathy following calcium hydroxylapatite‐based soft tissue filler injection: A case report

Ultrasound localization microscopy and functional ultrasound reveal atypical features of the live trigeminal ganglion

Contact Info

Product

Resources

About