Arteriogenesis and Therapeutic Angiogenesis in Its Multiple Aspects

Deindl, Elisabeth; Quax, Paul H.A.

doi:10.3390/cells9061439

Cited by 10 publications

(6 citation statements)

References 12 publications

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“…Chronic exposure to high levels of cholesterol and LDL-C results in functional and structural abnormalities of the vasculature, including endothelial dysfunction, subendothelial lipid deposition, plaque progression and compromised collateral vessel growth ( 21 , 22 ). In diabetic dyslipidemia, hypercholesterolemia and a predominant increase in sdLDL particles play negative roles in coronary collateral formation.…”

Section: Impact Of Diabetic Dyslipidemia On Collateral Formationmentioning

confidence: 99%

Diabetic dyslipidemia impairs coronary collateral formation: An update

Shen

Wang

Dai

et al. 2022

Front. Cardiovasc. Med.

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Coronary collateralization is substantially impaired in patients with type 2 diabetes and occlusive coronary artery disease, which leads to aggravated myocardial ischemia and a more dismal prognosis. In a diabetic setting, altered serum lipid profiles and profound glycoxidative modification of lipoprotein particles induce endothelial dysfunction, blunt endothelial progenitor cell response, and severely hamper growth and maturation of collateral vessels. The impact of dyslipidemia and lipid-lowering treatments on coronary collateral formation has become a topic of heightened interest. In this review, we summarized the association of triglyceride-based integrative indexes, hypercholesterolemia, increased Lp(a) with its glycoxidative modification, as well as quantity and quality abnormalities of high-density lipoprotein with impaired collateral formation. We also analyzed the influence of innovative lipid-modifying strategies on coronary collateral development. Therefore, clinical management of diabetic dyslipidemia should take into account of its effect on coronary collateralization in patients with occlusive coronary artery disease.

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Section: Impact Of Diabetic Dyslipidemia On Collateral Formationmentioning

confidence: 99%

Diabetic dyslipidemia impairs coronary collateral formation: An update

Shen

Wang

Dai

et al. 2022

Front. Cardiovasc. Med.

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“…The therapeutic idea of stimulating the formation of collateral arteries exogenously is one of the most important potential treatment alternatives that have been discussed and studied for these patients in recent years. [ 26 , 27 ] Some studies have shown better ventricular functions, as well as decreased angina attacks with the increased collateral circulation. [ 28 ] Even if it does not promise an absolute solution for the patients, it can contribute significantly to the increase in the quality of life.…”

Section: Discussionmentioning

confidence: 99%

The impact of the apelinergic system in coronary collateral formation

Özsöyler¹,

Uçak²,

Badak³

et al. 2023

Turk Gogus Kalp Dama

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Background: This study aims to examine the relationship between the development of coronary collateral circulation and serum elabela levels. Methods: Between January 2020 and December 2021, a total of 50 control individuals (29 males, 21 females; mean age: 63.2±10.0 years; range, 52 to 73 years) with no significant coronary artery disease as confirmed by angiography (Group 1) and 100 patients (55 males, 45 females; mean age: 66.6±9.6 years; range, 56 to 75 years) with coronary artery disease were included. The patients were further divided into two equal groups according to the Rentrop classification as poor (Group 2) and good coronary collateral circulation (Group 3). All groups were compared in terms of several parameters, particularly serum elabela levels. Results: Serum elabela levels were found to be statistically higher in the group with good collateral than the other groups (p<0.05). Low serum elabela levels increased the risk of developing weak collaterals by 2.43 times. Conclusion: The elabela protein is directly related to good collateral development and can be considered a potential agent for treatment.

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“…The therapeutic idea of stimulating the formation of collateral arteries exogenously is one of the most important potential treatment alternatives that have been discussed and studied for these patients in recent years. (23)(24)(25) Some studies have reported better ventricular functions as well as decreased angina attacks with increased collateral circulation. (26) Even if it does not promise an absolute solution for the patients, it can contribute signi cantly to the increase in the quality of life.…”

Section: Discussionmentioning

confidence: 99%

The İmpact Of The Apelinergic System In Coronary Collateral Formation

Özsöyler

Uçak

Badak

et al. 2022

Preprint

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Background: İn coronary artery disease, the positive contribution of the presence of coronary collateral circulation to the course of the disease is known. As for the factors that trigger the formation of collateral circulation and interactions at the cellular level, no satisfactory results have yet been reached. Studies on this issue will also pave the way for potential treatment opportunities in the future. The aim of this study is to try to determine the relationship between coronary collateral circulation and elabela and apelinergic system.Methods: This is a cross sectional study. Totally 150 subjects were included the study. Demographic data, laboratory test data, and comorbidities were collected from the hospital data. Welch, One Way Anova, Chi-Square, and Kruskal-Wallis H tests were used for comparison of the groups. Games-Howell, Tukey HSD, and Dunn tests were used for post-hoc analysis where necessary.Results: Evaluating the differences between the groups in terms of the parameters examined. Looking at which groups the differences arise from; it was observed that the statistically significant difference observed for elabela, HDL-C, NT-ProBNP, LVEF and HS-C-Reactive protein was between all groups separately.Conclusions: In this study, we aim to reveal a positive relationship between the development of coronary collateral vessels and apelinergic systems. Our results indicated that Elabela protein could be evaluated as a potential agent for treatment.

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Arteriogenesis and Therapeutic Angiogenesis in Its Multiple Aspects

Abstract: Arteriogenesis, also frequently called collateral formation or even therapeutic angiogenesis, comprises those processes that lead to the formation and growth of collateral blood vessels that can act as natural bypasses to restore blood flow to distal tissues in occluded arteries [...]

Cited by 10 publications

References 12 publications

Diabetic dyslipidemia impairs coronary collateral formation: An update

Diabetic dyslipidemia impairs coronary collateral formation: An update

The impact of the apelinergic system in coronary collateral formation

The İmpact Of The Apelinergic System In Coronary Collateral Formation

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