Arteriogenesis: Noninvasive Quantification with Multi–Detector Row CT Angiography and Three-dimensional Volume Rendering in Rodents

Zhuang, Zhen W.; Gao, Ling; Murakami, Masahiro; Pearlman, Justin D.; Sackett, Terry; Simons, Michael; Muinck, Ebo D. de

doi:10.1148/radiol.2403050976

Cited by 25 publications

(28 citation statements)

References 33 publications

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“…For visualization of the arterial collateral network after femoral artery occlusion, we performed µCT imaging (Zhuang et al, 2006). In short: 7 days after femoral artery occlusion, the abdominal aorta was cannulated and perfused with 100 mg/kg papaverin hydrochloride (Paveron, Weimer) to obtain maximal vasodilation, followed by perfusion with contrast agent.…”

Section: Microct Imagingmentioning

confidence: 99%

“…In short: 7 days after femoral artery occlusion, the abdominal aorta was cannulated and perfused with 100 mg/kg papaverin hydrochloride (Paveron, Weimer) to obtain maximal vasodilation, followed by perfusion with contrast agent. Hindlimb vascular network morphology was imaged and analyzed with a high resolution µCT imaging system, as described in detail previously (Zhuang et al, 2006).…”

Section: Microct Imagingmentioning

confidence: 99%

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Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models

et al. 2013

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SUMMARYArteriogenesis requires growth of pre-existing arteriolar collateral networks and determines clinical outcome in arterial occlusive diseases. Factors responsible for the development of arteriolar collateral networks are poorly understood. The Notch ligand Deltalike 4 (Dll4) promotes arterial differentiation and restricts vessel branching. We hypothesized that Dll4 may act as a genetic determinant of collateral arterial networks and functional recovery in stroke and hind limb ischemia models in mice. Genetic lossand gain-of-function approaches in mice showed that Dll4-Notch signaling restricts pial collateral artery formation by modulating arterial branching morphogenesis during embryogenesis. Adult Dll4 +/− mice showed increased pial collateral numbers, but stroke volume upon middle cerebral artery occlusion was not reduced compared with wild-type littermates. Likewise, Dll4 +/− mice showed reduced blood flow conductance after femoral artery occlusion, and, despite markedly increased angiogenesis, tissue ischemia was more severe. In peripheral arteries, loss of Dll4 adversely affected excitation-contraction coupling in arterial smooth muscle in response to vasopressor agents and arterial vessel wall adaption in response to increases in blood flow, collectively contributing to reduced flow reserve. We conclude that Dll4-Notch signaling modulates native collateral formation by acting on vascular branching morphogenesis during embryogenesis. Dll4 furthermore affects tissue perfusion by acting on arterial function and structure. Loss of Dll4 stimulates collateral formation and angiogenesis, but in the context of ischemic diseases such beneficial effects are overruled by adverse functional changes, demonstrating that ischemic recovery is not solely determined by collateral number but rather by vessel functionality.

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Section: Microct Imagingmentioning

confidence: 99%

Section: Microct Imagingmentioning

confidence: 99%

Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models

et al. 2013

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“…In this context, successful detection and characterization of vessel anomalies by medical imaging modalities as Computed Tomography Angiography (CTA) and Magnetic Resonance Angiography (MRA), requires efficient computational tools for visualization and analysis. Vessel segmentation methods may provide useful surgical planning information and may aid in diagnostics [2,3]. There are important challenges involving the characterization of vascular architectures: highresolution images that increases computational time and storage space; handling of bifurcations and successful detection of capillaries.…”

Section: Introductionmentioning

confidence: 99%

Vessel Centerline Tracking in CTA and MRA Images Using Hough Transform

Macedo

Mekkaoui

Jackowski

2010

Progress in Pattern Recognition, Image Analysis, Computer Vision, and Applications

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Abstract. Vascular disease is characterized by any condition that affects the circulatory system. Recently, a demand for sophisticated software tools that can characterize the integrity and functional state of vascular networks from different vascular imaging modalities has appeared. Such tools face significant challenges such as: large datasets, similarity in intensity distributions of other organs and structures, and the presence of complex vessel geometry and branching patterns. Towards that goal, this paper presents a new approach to automatically track vascular networks from CTA and MRA images. Our methodology is based on the Hough transform to dynamically estimate the centerline and vessel diameter along the vessel trajectory. Furthermore, the vessel architecture and orientation is determined by the analysis of the Hessian matrix of the CTA or MRA intensity distribution. Results are shown using both synthetic vessel datasets and real human CTA and MRA images. The tracking algorithm yielded high reproducibility rates, robustness to different noise levels, associated with simplicity of execution, which demonstrates the feasibility of our approach.

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“…Imaging angiogenesis could be a better approach to quantify microvascular density since it can be performed noninvasively and repeatedly. Several imaging techniques have been developed to image angiogenesis, including magnetic resonance imaging, computed tomography and ultrasound (6)(7)(8)(9). Advantages of ultrasound molecular imaging include the intravascular confinement of the contrast agents (facilitating simple analysis) and the high sensitivity of ultrasound to contrast agent echoes (facilitating the detection of a small number of microbubbles.…”

Section: Introductionmentioning

confidence: 99%

Imaging of angiogenesis using Cadence™ contrast pulse sequencing and targeted contrast agents

Stieger

Dayton

Borden

et al. 2008

Contrast Media & Molecular

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Arteriogenesis: Noninvasive Quantification with Multi–Detector Row CT Angiography and Three-dimensional Volume Rendering in Rodents

Abstract: BMC injection had a substantial effect on arteriogenesis, with normalization of total arterial area and volume in the BMC group; this effect was successfully depicted.

Cited by 25 publications

References 33 publications

Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models

Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models

Vessel Centerline Tracking in CTA and MRA Images Using Hough Transform

Imaging of angiogenesis using Cadence™ contrast pulse sequencing and targeted contrast agents

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