Arteriography and Vascular Studies in Paget's Disease of Bone

Storsteen, Kenneth A.

doi:10.1001/jama.1954.02940400010003

Cited by 24 publications

(9 citation statements)

References 1 publication

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“…However, several studies utilizing different techniques have failed to demonstrate arteriovenous fistulas (3)(4)(5). The present study may provide an alternative explanation for the elevated venous oxygen tension in Paget's disease.…”

Section: Resultsmentioning

confidence: 51%

“…Previous studies (4,5) flow to bone have not been reported. We suggest that there probably is a modest increase in blood flow to bone in Paget's disease (as indicated by previous studies), but that most of the increase in blood flow to extremities is the result of cutaneous vasodilatation.…”

Section: Resultsmentioning

confidence: 88%

“…It has been suggested that the increase in blood flow can be explained by arteriovenous fistulas in bone (3), since the oxygen tension in venous blood from "Pagetic" extremities is elevated (2). Although there is proliferation of vessels in bones with Paget's disease (2), neither histologic studies (3), arteriograms (4), nor injection of isotope-labeled microspheres (5) has demonstrated arteriovenous fistulas.…”

Section: Introductionmentioning

confidence: 99%

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Regulation of blood flow in Paget's disease of bone.

Heistad¹,

Abboud²,

Schmid³

et al. 1975

J. Clin. Invest.

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Section: Resultsmentioning

confidence: 51%

Section: Resultsmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Regulation of blood flow in Paget's disease of bone.

Heistad¹,

Abboud²,

Schmid³

et al. 1975

J. Clin. Invest.

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“…There have been efforts to evaluate bone vascularization in PD, but none of the described methods are routinely used for this purpose in clinical practice [8][9][10][11][12][13]. This has changed with the introduction of DCE-MRI, which has been proven as a valid and non-invasive method for semiquantitative evaluation of microcirculation in solid tumors and bone marrow disease [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Dynamic contrast-enhanced MRI in Paget’s disease of bone–correlation of regional microcirculation and bone turnover

et al. 2008

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The purpose of this study was to evaluate regional microcirculation in Paget's disease of bone (PD) with dynamic contrast-enhanced MR imaging (DCE-MRI). Additionally, we correlated regional bone perfusion with alkaline phosphatase as serum marker of bone turnover. We examined 71 patients with PD (27 men, 44 women, 67+/-10 years) localized at the axial and appendicular skeleton. Contrast uptake was analyzed using a two-compartment model with the output variables amplitude A and exchange rate constant k(ep). Color-coded parametric images were generated to visualize microcirculation. Serum levels of alkaline phosphatase (AP) were compared with DCE-MRI parameters. Amplitude A and exchange rate constant k(ep) were significantly increased in PD compared to unaffected bone (A(PD) 0.81+/-0.24 vs. A(control) 0.34+/-0.1 and k(ep PD) 4.0+/-2.86 vs. k(ep control) 1.73+/-0.88, p<0.001). There was a significant correlation (r(s)=0.5-0.7) of DCE-MRI parameters and AP at the axial (pelvis, spine) and appendicular skeleton (femur, tibia). The long bones showed increased circulation of the advancing peripheral zones and no vascularization of the central part, which had been replaced by fatty tissue. Regional microcirculation in PD is inhomogeneous with focal areas of excessive hypervascularity, especially in the advancing peripheral zone. There is a significant correlation of bone circulation and bone turnover in PD. DCE-MRI might therefore be a diagnostic tool for monitoring therapeutic effects of bisphosphonates in Paget's disease of bone.

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“…Later, however, they came to regard plethysmography as unsatisfactory for quantitative measurements owing to immeasurable venous drainage via the medulla (Edholm & Howarth, 1953). No other quantitative measurements of bone blood flow in Paget's disease have been reported, although arteriography (Storsteen & Janes, 1954) and radionuclide-uptake studies (Fletcher, Butler, Henry, Solaric-George & Donati, 1973) have provided indirect evidence of the increased bone blood flow.…”

Section: Introductionmentioning

confidence: 99%

Skeletal Blood Flow in Paget's Disease of Bone and its Response to Calcitonin Therapy

et al. 1978

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1. Blood flow to the skeleton was measured by the 18F clearance method of Wooton, Reeve & Veall (1976) in 24 patients with untreated Paget's disease. In every patient but one, resting skeletal blood flow was increased. There was a significant positive correlation between skeletal blood flow and serum alkaline phosphatase and between skeletal blood flow and urinary total hydroxyproline excretion. 2. Fourteen patients were re-studied after they had received short-term (7 days or less) or long-term (7 weeks or more) calcitonin. Skeletal blood flow, alkaline phosphatase and urinary hydroxy-proline excretion fell towards normal in every case. There was some evidence from the short-term studies that calcitonin produced a more rapid fall in skeletal blood flow than in alkaline phosphatase. 3. Glomerular filtration rate appeared to increase transiently in response to calcitonin.

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Arteriography and Vascular Studies in Paget's Disease of Bone

Cited by 24 publications

References 1 publication

Regulation of blood flow in Paget's disease of bone.

Regulation of blood flow in Paget's disease of bone.

Dynamic contrast-enhanced MRI in Paget’s disease of bone–correlation of regional microcirculation and bone turnover

Skeletal Blood Flow in Paget's Disease of Bone and its Response to Calcitonin Therapy

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