Arteriovenous Fistula for Long-Range Vascular Access in Dogs

Ds, Terman; García‐Rinaldi, Raúl; Poser, Robert D.; Dannemann, Brian; Crumb, C. K.

doi:10.1097/00002480-197700230-00074

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1980

1986

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“…During a 14-day control period preceding the treatments, all the visible neoplasms grew noticeably. Protein A (Pharmacia) (1.0 mg per kilogram of body weight) was immobilized in collodion charcoal by a slight modification of previously described methods (7)(8)(9)(10)(11)(12). With '251-labeled protein A used as a marker (unlabeled protein A was used in preparation of the immunoadsorbent), 95.6 to 97.8 percent of the added protein A was bound in the charcoal.…”

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confidence: 99%

Tumoricidal Response Induced by Cytosine Arabinoside After Plasma Perfusion Over Protein A

Terman

Yamamoto

Tillquist

et al. 1980

Science

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In dogs with spontaneous mammary adenocarcinomas, a single nontoxic infusion of cytosine arabinoside after extracorporeal perfusion of plasms over immobilized protein A resulted in a necrotizing response rapid in onset and specific for tumorous tissue. Gross tumoricidal reactions 12 hours after this combined treatment exceeded the algebraic sum of responses to cytosine arabinoside and protein A perfusion treatments alone in the same dogs, implying a synergistic effect between the two. The magnitude, rapidity, and specificity of the tumoricidal response after the combined treatment suggests that it may be an effective chemimmunotherapeutic approach to breast adenocarcinoma.

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confidence: 99%