Artesunate-tinospora combination treatment decreases nuclear factor kappa-B and intercellular adhesion  molecule-1 expression in mouse malarial models

Izzati, Nur; Fitri, Loeki Enggar; Dalhar, Mochammad

doi:10.18051/univmed.2016.v35.222-228

Cited by 2 publications

(2 citation statements)

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“…Miers Akanadi Climber Leaves Paralysis (Ch), vertigo, mental disorder Antinociceptive [ 13 , 97 , 160 , 219 , 220 ] Tinospora crispa (L.) Hook.f. & Thomson Gulancha Climber Leaves, stem Paralysis Cerebral malaria [ 118 , 221 ] Moraceae Ficus auriculata Lour. Kani-bot Tree Root Epilepsy NRE [ 101 ] Ficus hispida L.f. Dumur Tree Leaves, flower, seed, root, bark Epilepsy, paralysis CNS stimulation [ 101 , 222 ] Ficus benghalensis L. Bot Tree Aerial root, bark Epilepsy Antinociceptive [ 93 , 223 ] Ficus hederacea Roxb.…”

Section: Introductionmentioning

confidence: 99%

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Uddin

Zidorn

2020

Nat. Prod. Bioprospect.

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The majority of the population in Bangladesh uses traditional plant-based medicines to manage various ailments, including central nervous system (CNS) disorders. This review presents ethnobotanical information and relevant scientific studies on plants used in traditional healthcare for the management of various CNS disorders in Bangladesh. The information on the medicinal plants of Bangladesh effective against CNS disorders published in scientific journals, books, and reports was compiled from different electronic databases using specific key words. The present article provides comprehensive information on a total of 224 medicinal plant species belonging to 81 families used for the treatment of CNS disorders by the various peoples of Bangladesh. In total, we reviewed more than 290 relevant papers. In this study, leaves were found as the most often used plant organ, followed by roots, fruits, whole plants, barks, seeds, stems, rhizomes, and flowers. The Fabaceae family contributes the highest number of used species, followed by Rubiaceae, Lamiaceae, Cucurbitaceae, Vitaceae, Euphorbiaceae, Malvaceae, and Zingiberaceae. The most frequently used species (in decreasing order) are Asparagus racemosus, Centella asiatica, Stephania japonica, Aegle marmelos, Coccinia grandis, Tabernaemontana divaricata, Bacopa monnieri, Abroma augusta, and Scoparia dulcis. This review may serve as a starting point for a rational search for neuroactive natural products against CNS disorders within the Flora of Bangladesh. Graphic Abstract

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Section: Introductionmentioning

confidence: 99%

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Uddin

Zidorn

2020

Nat. Prod. Bioprospect.

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“…Three combinations of artesunate (32 mg/kg) were prepared using three doses of the aqueous extract (2.5, 3 and 3.5 mg/kg) and administrated to C57BL/6 J mice infected with P. berghei . This caused a substantial inhibition of Nuclear Factor Kappa B (NFκB) and Intracellular Adhesion Molecule-1 (ICAM1) compared to the artesunate or extract only groups (Izzati et al 2016 ). The aqueous extract of T. cripsa stems was also assessed against Brugia malayi, amongst other parasites, to evaluate its antifilarial potential.…”

Section: Pharmacological Activitymentioning

confidence: 99%

An updated and comprehensive review on the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile of Tinospora crispa (L.) Hook. f. & Thomson

et al. 2022

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Tinospora crispa (L.) Hook. f. & Thomson (Menispermaceae) is a plant indigenous to Africa and South-East Asia. It is widely used in ethnomedicine to alleviate various diseases including hypertension, diabetes, rheumatism, jaundice, inflammation, fever, fractures, scabies, and urinary disorders. A total of 167 phytoconstituents, belonging to 12 different chemical categories, including alkaloids, flavonoids, terpenoids, and phenolic compounds have thus far been isolated from various parts of T. crispa. Numerous in vitro and in vivo investigations have already established the antidiabetic, anticancer, antiparasitic, antimicrobial, immunomodulatory, hepatoprotective, analgesic, antipyretic, antihyperuricemic, and pesticidal activity of this plant, as well as its effects on the cardiac and the central nervous system. Most pharmacological investigations to date have been carried out on plant extracts and fractions. The exact identity of the phytoconstituents responsible for the observed biological effects and their mode of action at the molecular level are yet to be ascertained. Toxicological studies have demonstrated that T. crispa is relatively safe, although dose-dependent hepatotoxicity is a concern at high doses. This review presents a comprehensive update and analysis on studies related to the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile of T. crispa. It provides some critical insights into the current scientific knowledge on this plant and its future potential in pharmaceutical research.

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Artesunate-tinospora combination treatment decreases nuclear factor kappa-B and intercellular adhesion molecule-1 expression in mouse malarial models

Cited by 2 publications

References 18 publications

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

An updated and comprehensive review on the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile of Tinospora crispa (L.) Hook. f. & Thomson

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