Arthritis and coeliac disease.

Bourne, J. T.; Kumar, Parveen; Huskisson, E.C.; Mageed, RA; Unsworth, D J; Wojtulewski, J A

doi:10.1136/ard.44.9.592

Cited by 90 publications

(24 citation statements)

References 16 publications

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“…This confirmed an earlier, small case series that showed improvement of the joint symptoms in newly diagnosed celiac disease patients following treatment with a gluten free diet. [22] The mechanisms underlying these arthritic complaints in CD are unknown though the alterations in intestinal permeability in untreated CD may be factor.…”

Section: Inflammatory Arthritismentioning

confidence: 99%

Celiac Disease and Autoimmunity in the Gut and Elsewhere

Barton

Murray

2008

Gastroenterology Clinics of North America

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Section: Inflammatory Arthritismentioning

confidence: 99%

Celiac Disease and Autoimmunity in the Gut and Elsewhere

Barton

Murray

2008

Gastroenterology Clinics of North America

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“…A forma não clássica da DC manifesta-se mais tardiamente, com quadro mono ou paucissintomático. Os pacientes deste grupo podem apresentar manifestações isoladas, como por exemplo baixa estatura [10][11][12][13] , anemia por deficiência de ferro refratária à ferroterapia oral [14][15][16] , hipoplasia do esmalte dentário [17][18][19] , constipação intestinal 20 , osteoporose 21 , esterilidade 22 , artralgia ou artrite 23 e epilepsia associada a calcificação intracraniana 24 . O reconhecimento da forma assintomática da doença, especialmente entre familiares de primeiro grau de pacientes celíacos 25 , tornou-se mais fácil a partir do desenvolvimento de marcadores sorológicos específicos para a DC 26,27 .…”

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Celiac disease: clinical characteristics and methods used in the diagnosis of patients registered at the Brazilian Celiac Association

2001

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ResumoObjetivo: avaliar as características clínicas e os métodos utilizados no diagnóstico dos pacientes cadastrados na Associação dos Celíacos do Brasil -Seção São Paulo.Métodos: foi enviado por correio um questionário a respeito das características clínicas e dos métodos diagnósticos da doença celí-aca para 584 membros cadastrados.Resultados: foram analisados 289 questionários respondidos (49,5%) dos 584 enviados. Quanto às características clínicas da doença celíaca no momento do diagnóstico, observou-se que na amostra estudada a forma clássica foi mais freqüente (88,9%) do que a forma não clássica (11,1%). Nos últimos cinco anos houve aumento da proporção da forma clássica tardia de 44,5% para 64,2% (p=0,004) e da forma não clássica de 5,2% para 16,8% (p=0,005). O tempo de duração dos sintomas até o estabelecimento do diagnóstico foi superior a 1 ano em 75% dos pacientes com manifestação clínica não clássica. Biópsia de intestino delgado não foi realizada no momento do diagnóstico em 19% dos pacientes. Observou-se que, nos últimos 5 anos, maior número de pacientes (24,4%) não realizaram biópsia de intestino delgado no momento do diagnóstico em relação aos realizados há 5 ou mais anos (11,1%) (p=0,007).Conclusões: na amostra estudada, a forma clássica continua sendo a manifestação clínica mais freqüente da doença celíaca. Apesar do predomínio da forma clássica tardia, observamos aumento da proporção da forma não clássica. 19% dos pacientes diagnosticados como portadores de doença celíaca não realizaram biópsia de intestino delgado no momento do diagnóstico, especialmente nos últimos 5 anos, apesar de a caracterização da atrofia vilositária subtotal ou total da mucosa do intestino delgado ser um critério imprescindível para o diagnóstico de doença celíaca.J Pediatr (Rio J) 2001; 77 (2): 131-8: doença celíaca, sinais e sintomas, diagnóstico, diarréia, desnutrição protéico-energética. AbstractObjective: to evaluate the clinical characteristics and methods used in the diagnosis of patients registered at the Brazilian Celiac Association (BCA).Methods: a questionnaire about clinical characteristics and diagnostic methods in celiac disease was mailed to 584 members of the BCA.Results: we received 292 responses for 584 questionnaires mailed (49.5%). The clinical characteristics of celiac disease in the sample we analyzed showed that the most frequent type was the classical mode (88.9%), while the atypical mode was present in only 11.1% of patients at the time of diagnosis. Increased incidence of both late diagnosed classical mode (44.5% to 64.2%; P=.004) and atypical mode (5.2% to 16.8%; P=.005) has been observed in the last 5 years. Duration of symptoms before diagnosis was greater than 1 year in 75% patients with atypical manifestation. Intestinal biopsy was not performed in 19% of the cases at the time of diagnosis. It was observed that in the last 5 years intestinal biopsy was not performed for a larger number of patients (24.4%) than in the previous period (only 11.1%) (P=.007).Conclusions: classical mode is stil...

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“…Dextran and anti-dextran antibodies have been known to appear in patients with gastrointestinal diseases and some colorectal carcinomas. These disorders seem to be linked to gut pathology, which is underlined by the facts that arthritis is an extraintestinal manifestation of Crohn's disease and that rheumatic diseases occur in patients with gluten-enteropathy more frequently than in the general population (Greenstein et al, 1976;Bourne et al, 1985). However, there is no hard evidence suggesting that dextran epitopes are specifically present in the gut.…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of serum antibodies against alpha-1, 6-glucan in patients with systemic lupus erythematosus or rheumatoid arthritis

Dai

Gao²

2011

Protein Cell

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This study was undertaken to investigate whether levels of anti-alpha-1, 6-glucan antibodies in human sera correlate with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Serum samples were collected from patients with SLE (n = 30), RA (n = 30) and healthy adult volunteers. IgG, IgA and IgM levels against alpha-1, 6-glucan were measured using enzyme linked immunosorbent assays. Anti-alpha-1, 6-glucan IgG prevalence was raised in patients with active SLE (73.3%) and RA (60%) compared with healthy controls (13.3%). Strong correlation between anti-alpha-1,6-glucan-IgG levels and anti-perinuclear factor (r = 0.642; p < 0.05) in RA patients or anti-nuclear antibodies (r = 0.675; p < 0.05) in SLE patients was observed. No significant differences in anti-alpha-1,6-glucan-IgA or-IgM levels were noted between different groups. We conclude that anti-alpha-1,6-glucan-IgG levels were significantly elevated in patients with SLE or RA and positively correlated with disease activity.

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Arthritis and coeliac disease.

Cited by 90 publications

References 16 publications

Celiac Disease and Autoimmunity in the Gut and Elsewhere

Celiac Disease and Autoimmunity in the Gut and Elsewhere

Celiac disease: clinical characteristics and methods used in the diagnosis of patients registered at the Brazilian Celiac Association

Elevated levels of serum antibodies against alpha-1, 6-glucan in patients with systemic lupus erythematosus or rheumatoid arthritis

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