Arthritis associated with non-alcoholic steatohepatitis

Habib, Gaston

doi:10.1136/ard.60.8.815a

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…It also appeared that patients with NAFLD and hepatitis C both had joint pain interpreted by us as inflammatory, or upon questioning was associated with morning stiffness, symmetry, and swelling. A case report by Habib and Saliba [5] (the only known report of joint complaints in NAFLD) describes a NASH patient with symmetrical arthritis and morning stiffness that resolved when dietary change resulted in normalization of serum liver function tests. However, with a rise in the serum liver function tests owing to dietary reversal, the joint complaints reappeared.…”

Section: Discussionmentioning

confidence: 96%

“…The majority of NAFLD patients present without systemic complaints, and a small minority may present with fatigue or vague right upper quadrant pain [4]. Arthralgias, arthritis, or both were not previously thought to be associated with NAFLD as it has been with HCV, but arthritic symptoms have been reported [5]. Because the pathophysiology of NAFLD can involve inflammatory mediators leading to liver inflammation, systemic symptoms may be possible [4].…”

Section: Introductionmentioning

confidence: 97%

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Musculoskeletal Complaints and Serum Autoantibodies Associated with Chronic Hepatitis C and Nonalcoholic Fatty Liver Disease

2007

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We sought to compare the musculoskeletal symptoms and immune markers found in chronic hepatitis C (HCV) and nonalcoholic fatty liver disease (NAFLD). Patients with HCV or NAFLD answered a questionnaire and donated serum for autoantibody testing. Univariate analysis between the HCV and NAFLD groups revealed joint pain in 67% of the HCV group and 65% of the NAFLD group. Those with joint pain reported inflammatory characteristics that were similar between the groups. The presence of a positive rheumatoid factor and cryoglobulins was higher in the HCV group, however both groups had a similar prevalence of a low positive antinuclear antibody (ANA). We conclude that the NAFLD group reported a higher amount of joint pain and inflammatory joint symptoms than anticipated. We were unable to determine a variable that predicted the presence of joint pain. Therefore, more investigation is needed to determine whether these findings are due to liver disease alone.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 97%

Musculoskeletal Complaints and Serum Autoantibodies Associated with Chronic Hepatitis C and Nonalcoholic Fatty Liver Disease

2007

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“…BMI was added sequentially after age and sex in model 2. Lifestyle variables (total calorie intake, sleep duration, smoking, alcohol, education level) were added to model 3, and comorbidities (diabetes mellitus (DM), cardiovascular disease, hypertension, and arthritis) were further added to model 4, and finally central obesity was added to model 5, according to their established associations with physical activity and NAFLD and clinical relevance [3,9,10,12,16,22,23,24,25,26]. All analyses were performed by the complex sample procedures of SPSS (version 24; IBM/SPSS Inc., Armonk, NY, USA) to account for the complex sampling design.…”

Section: Methodsmentioning

confidence: 99%

Independent Association of Physical Activity with Nonalcoholic Fatty Liver Disease and Alanine Aminotransferase Levels

Jang

Lee

Kim

2019

JCM

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The aim of the current study was to examine the independent association of physical activity with nonalcoholic fatty liver disease (NAFLD) and aminotransferases while adjusting for obesity and diet. Cross-sectional data from 32,391 participants aged ≥ 20 years in the Korea National Health and Nutrition Examination Surveys (KNHANES) was analyzed by logistic regression models and general linear models. Physical activity was assessed from the questionnaire by health-enhancing physical activity (HEPA). The physical activity was negatively associated with NAFLD and lean NAFLD after adjustment for multiple factors with an odds ratio of 0.7 (95% CI, 0.6–0.8) and 0.5 (95% CI, 0.4–0.7) comparing the most active (HEPA active) and the least active (inactive) participants. Among the participants with NAFLD, physical activity also showed an independent negative association with alanine aminotransferase (ALT) levels but not with aspartate aminotransferase levels. These independent associations were not observed when comparing the minimally active and inactive participants except for the risk of lean NAFLD. Physical activity is independently associated with the degree of hepatocellular injury in patients with NAFLD as well as the risk of NAFLD and lean NAFLD in the general population. Sufficiently active physical activity greater than a minimally active level may be needed to lower the risk of NAFLD and ALT levels.

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Increased oxidative activity from hydrogen peroxide may be the cause of the predisposition to cataracts among patients with atopic dermatitis

2006

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Arthritis associated with non-alcoholic steatohepatitis

Cited by 4 publications

References 11 publications

Musculoskeletal Complaints and Serum Autoantibodies Associated with Chronic Hepatitis C and Nonalcoholic Fatty Liver Disease

Musculoskeletal Complaints and Serum Autoantibodies Associated with Chronic Hepatitis C and Nonalcoholic Fatty Liver Disease

Independent Association of Physical Activity with Nonalcoholic Fatty Liver Disease and Alanine Aminotransferase Levels

Increased oxidative activity from hydrogen peroxide may be the cause of the predisposition to cataracts among patients with atopic dermatitis

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