Arthrospira maxima OF15 biomass cultivation at laboratory and pilot scale from sugarcane vinasse for potential biological new peptides production

Montalvo, Grecia Esthefany Barriga; Soccol, Vanete Thomaz; Vandenberghe, Luciana Porto de Souza; Carvalho, Júlio César de; Faulds, Craig B.; Bertrand, Emmanuel; Prado, Maria Rosa Machado; Bonatto, Sandro José Ribeiro; Soccol, Carlos Ricardo

doi:10.1016/j.biortech.2018.10.081

Cited by 73 publications

(31 citation statements)

References 44 publications

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“…Another study, conducted by Yamaguchi and Koketsu [ 19 ], showed that Nostochopsis lobatus MAC0804NAN produced a large amount of polysaccharides with a high inhibitory effect (IC 50 = 7.18 µg/mL). It was also reported that an Arthrospira -derived peptide may be involved in hyaluronidase inhibition [ 43 ]. Together, these results support the potential of cyanobacteria compounds and extracts as anti-aging ingredients for cosmeceutical applications.…”

Section: Resultsmentioning

confidence: 99%

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

et al. 2022

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The loss of density and elasticity, the appearance of wrinkles and hyperpigmentation are among the first noticeable signs of skin aging. Beyond UV radiation and oxidative stress, matrix metalloproteinases (MMPs) assume a preponderant role in the process, since their deregulation results in the degradation of most extracellular matrix components. In this survey, four cyanobacteria strains were explored for their capacity to produce secondary metabolites with biotechnological potential for use in anti-aging formulations. Leptolyngbya boryana LEGE 15486 and Cephalothrix lacustris LEGE 15493 from freshwater ecosystems, and Leptolyngbya cf. ectocarpi LEGE 11479 and Nodosilinea nodulosa LEGE 06104 from marine habitats were sequentially extracted with acetone and water, and extracts were analyzed for their toxicity in cell lines with key roles in the skin context (HaCAT, 3T3L1, and hCMEC). The non-toxic extracts were chemically characterized in terms of proteins, carotenoids, phenols, and chlorophyll a, and their anti-aging potential was explored through their ability to scavenge the physiological free radical superoxide anion radical (O2•−), to reduce the activity of the MMPs elastase and hyaluronidase, to inhibit tyrosinase and thus avoid melanin production, and to block UV-B radiation (sun protection factor, SPF). Leptolyngbya species stood out for anti-aging purposes: L. boryana LEGE 15486 presented a remarkable SPF of 19 (at 200 µg/mL), being among the best species regarding O2•− scavenging, (IC50 = 99.50 µg/mL) and also being able to inhibit tyrosinase (IC25 = 784 µg/mL), proving to be promising against UV-induced skin-aging; L. ectocarpi LEGE 11479 was more efficient in inhibiting MMPs (hyaluronidase, IC50 = 863 µg/mL; elastase, IC50 = 391 µg/mL), thus being the choice to retard dermal density loss. Principal component analysis (PCA) of the data allowed the grouping of extracts into three groups, according to their chemical composition; the correlation of carotenoids and chlorophyll a with MMPs activity (p < 0.01), O2•− scavenging with phenolic compounds (p < 0.01), and phycocyanin and allophycocyanin with SPF, pointing to these compounds in particular as responsible for UV-B blockage. This original survey explores, for the first time, the biotechnological potential of these cyanobacteria strains in the field of skin aging, demonstrating the promising, innovative, and multifactorial nature of these microorganisms.

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Section: Resultsmentioning

confidence: 99%

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

et al. 2022

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“…Arthrospira maxima is another example of cyanobacteria able to produce anti-collagenase peptides. The peptide fraction PHS showed anti collagenase activity (92.5%) with an IC 50 of 32.5 mg/ mL compared with the synthetic inhibitor (57.13%) 42 . These peptides sequence can resemble the cleavage site in native collagen, and thus prevent the degradation of the ECM.…”

Section: Collagenasesmentioning

confidence: 95%

Cyanobacteria and microalgae bioactive compounds in skin-ageing: potential to restore extracellular matrix filling and overcome hyperpigmentation

Favas

Morone

Martíns

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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As the largest organ in human body, skin acts as a physicochemical barrier, offering protection against harmful environmental stressors, such as chemicals, pathogens, temperature and radiation. Nonetheless, skins prominence goes further, with a significant psychosocial role in an increasingly ageing population. Prompted by consumers' concern regarding skincare, cosmetic industry has been developing new formulas capable of lessening the most visible signs of ageing, including reduction in skin density and elasticity, wrinkling and hyperpigmentation. Allied to skincare is the rising importance set on natural products, sustainably obtained from less environmental impacting methods. Cyanobacteria and microalgae are adding importance in this field, given their ability to biosynthesize secondary metabolites with anti-ageing potential. In this review, we present an overview on the potential of cyanobacteria and microalgae compounds to overcome skin-ageing, essentially by exploring their effects on the metalloproteinases collagenase, elastase, gelatinase and hyaluronidase, and in other enzymes involved in the pigmentation process.

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“…Chlorella accumulate high concentrations of carotenoids (astaxanthin, lutein, β-carotene, violaxanthin and zeaxanthin), antioxidants, vitamins, polysaccharides, proteins, peptides and fatty acids [5,38]. In addition to all the benefits mentioned, the bioactive compounds of microalgae can have a biological, immune, antiviral and anti-cancer properties, being highly active [39].…”

Section: Application Of Microalgaementioning

confidence: 99%

Microalgae Growth under Mixotrophic Condition Using Agro-Industrial Waste: A Review

Pereira¹,

Rangel²,

Chagas³

et al. 2021

Biotechnological Applications of Biomass

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Microalgae has a great potential to produce biofuels and bioproduct but the cost is still too high mainly due to the biomass production. Mixotrophic cultivation has been pointed as microalgae cultivation mode for biomass/bioenergy production with lower cost and able to make remediation of organic waste. The proposals of this work was to make a review of microalgae growth under mixotrophic condition using agro-industrial waste. Agro-industrial by-products and wastes are of great interest as cultivation medium for microorganisms because of their low cost, renewable nature, and abundance. However biotechnological technologies are necessary to develop the production of microalgae on a large scale.

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Arthrospira maxima OF15 biomass cultivation at laboratory and pilot scale from sugarcane vinasse for potential biological new peptides production

Abstract: . Arthrospira maxima OF15 biomass cultivation at laboratory and pilot scale from sugarcane vinasse for potential biological new peptides production.

Cited by 73 publications

References 44 publications

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

Cyanobacteria and microalgae bioactive compounds in skin-ageing: potential to restore extracellular matrix filling and overcome hyperpigmentation

Microalgae Growth under Mixotrophic Condition Using Agro-Industrial Waste: A Review

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