Arthus Reaction as an Adverse Event Following Tdap Vaccination

Pool, Vitali; Mege, Larissa; Abou‐Ali, Adel

doi:10.3390/vaccines8030385

Cited by 6 publications

(6 citation statements)

References 18 publications

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“…57 The occurrence of large, local injection-site reactions with TdaP vaccines has been reported to be due to a local immune complex type III hypersensitivity reaction. 58 Type IV hypersensitivity reactions occur when an individual's T cells provoke an inflammatory response against allergens, leading to T-cell activation and the release of cytokines and chemokines. 59 Type IV reactions to vaccines induce local eczema, which may start between 2 hours to up to 2 days after vaccinations.…”

Section: S Ec Ti On Iv: G Ener Al Mechanis Ms In Pathways Of Immune-med Iated and Non -Immune-mediated Re Ac Tionsmentioning

confidence: 99%

“…Type II IgG‐mediated immune vaccine reactions are rare but have been observed with an MMR vaccine containing dextran before those preparations were taken off the market 57 . The occurrence of large, local injection‐site reactions with TdaP vaccines has been reported to be due to a local immune complex type III hypersensitivity reaction 58 . Type IV hypersensitivity reactions occur when an individual's T cells provoke an inflammatory response against allergens, leading to T‐cell activation and the release of cytokines and chemokines 59 .…”

Section: Section Iv: General Mechanisms In Pathways Of Immune‐mediated and Non‐immune‐mediated Reactionsmentioning

confidence: 99%

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Vaccines and allergic reactions: The past, the current COVID‐19 pandemic, and future perspectives

Sampath

Rabinowitz

Shah

et al. 2021

Allergy

123

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The rapid development and the launch of several novel COVID-19 vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an extraordinary and remarkable accomplishment of modern science. The Pfizer-BioNTech BNT162b2 was the first vaccine to be granted temporary authorization for emergency use by the Medicines and Healthcare Products Regulatory Agency (MHRA) in the U.K for the treatment of COVID-19 on 2 December 2020. 1 Soon after, on 11 December 2020, it also received emergency use authorization (EUA) by the U.S. Food and Drug Administration (FDA). 2 EUA is a mechanism to facilitate the availability of vaccines during public health emergencies, such as the current COVID-19 pandemic. Under an EUA, the FDA may allow the use of unapproved medical products (including vaccines) to prevent serious or life-threatening disease when certain statutory criteria have been met and no adequate and/or approved alternatives are available. The authorization of BNT162b2 was followed by an EUA for a second COVID-19 vaccine, the Moderna mRNA-1273 on 18 December 2020. 3 This was followed by the authorization of mRNA-1273 for use by other regulatory agencies such as the European Commission, UK MHRA, Israel Ministry of

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Section: S Ec Ti On Iv: G Ener Al Mechanis Ms In Pathways Of Immune-med Iated and Non -Immune-mediated Re Ac Tionsmentioning

confidence: 99%

Section: Section Iv: General Mechanisms In Pathways Of Immune‐mediated and Non‐immune‐mediated Reactionsmentioning

confidence: 99%

Vaccines and allergic reactions: The past, the current COVID‐19 pandemic, and future perspectives

Sampath

Rabinowitz

Shah

et al. 2021

Allergy

123

View full text Add to dashboard Cite

show abstract

“…Arthus involves the in situ formation of antigenantibody complexes after the injection of an antigen with high levels of circulating antibodies. It manifests as local vasculitis due to the deposition of IgG-based immune complexes in dermal blood vessels [21] .…”

Section: Table (3): Results Of Arthus Reaction/mm In Studied Groupsmentioning

confidence: 99%

Effect of Staphylococcus aureus Thermostable DNase on Some Immunological Parameters

Noor Naeem Khwen,

Sawsan Hassan Authman,

Mohammed Faraj AL- Marjani

2021

Indian Journal of Forensic Medicine & Toxicology

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Thermostable DNase was purified from Staphylococcus aureus isolated from local clinical source. The current study includes different immunological assays to evaluate the role of purified DNase. The phagocytic activity showed that the group of mice infected with P.aeruginosa recorded the highest values with significant differences (P <0.05) in comparison with the group that received mixed injection of 1 µg /ml of DNase and P. aeruginosa showed decrease in phagocytic activity followed by group that injected by 1 µg /ml DNase only with phagocytic activity 2%. DNase has a positive immunomodulatory effect on IL-10 and IL-4 level. The data showed that the highest value of IL-10 is in group that injected with 1 µg /ml DNase only (IV group) was 86.79±1.68. While the highest value of IL-4 was in group that injected with both DNase (1 µg /mouse) and P.aeruginosa gave the highest values (III group) was 84.02 ±1.19. In Arthus reactions(Immediate type hypersensitivity), the group that have been injected with both DNase and P. aeruginosa (group III ) gave the highest values (4.50±0.70) while in delayed type hypersensitivity the same group III showed higher values after 24 and 48 hrs (5.00±0.00) , (4.00±0.00) respectively.

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“…If a woman during the reproductive period has not had vaccinations against diphtheria, tetanus, and pertussis, then at any age they should be supplemented [ 40 , 41 ]. The vaccination schedule includes the administration of one dose of dTpa.…”

Section: Recommendations For Vaccination Of Adolescents and Adults In...mentioning

confidence: 99%

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

Bednarek,

Laskowska

2024

Med Sci Monit

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Vaccinations are an essential element of public health programs around the world, which have a major impact on morbidity, mortality, and costs of the health care system. In recent years, with a better understanding of the effectiveness and safety of vaccinations, many recommendations have been developed for administering vaccines to adults. Countless physiological changes occur during pregnancy, including those affecting the immune system. Pregnant women are at increased risk of developing infections and resulting complications. According to research, vaccines are immunogenic and safe for pregnant women. Pregnancy is not an absolute contraindication to vaccination. After administration of vaccines to pregnant women, the concentration of antibodies increases, which can be transferred to the child in the second and third trimesters of pregnancy and provide protection in the first months of life. The Advisory Committee on Immunization Practices (ACIP) , guidelines of the Centers for Disease Control and Prevention (CDC) , and the American College of Obstetrics and Gynecology (ACOG) unanimously recommend vaccination of pregnant women if a safe vaccine is available and there is a risk of exposure of the woman to a disease that threatens herself or her developing baby. In everyday clinical practice, medical professionals should provide their patients with the necessary information on vaccinations, which may contribute to greater awareness and implementation of vaccinations. This article aims to review current global recommendations for the vaccination of pregnant and breastfeeding women, including against the Omicron variants of SARS-CoV-2.

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Arthus Reaction as an Adverse Event Following Tdap Vaccination

Cited by 6 publications

References 18 publications

Vaccines and allergic reactions: The past, the current COVID‐19 pandemic, and future perspectives

Vaccines and allergic reactions: The past, the current COVID‐19 pandemic, and future perspectives

Effect of Staphylococcus aureus Thermostable DNase on Some Immunological Parameters

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

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