Articular cartilage repair: the role of bone morphogenetic proteins

Pećina, Marko; Jelić, Mislav; Martinović, Snježana; Hašpl, Miroslav; Vukičević, Slobodan

doi:10.1007/s00264-002-0338-4

Cited by 43 publications

(4 citation statements)

References 41 publications

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“…These growth factors influence endochondral bone formation, proliferation, matrix synthesis, and defect healing in vivo . 218,224 Increased matrix (e.g., proteoglycans and collagen) synthesis, and cell proliferation have been demonstrated using BMP-2, 221,224–226 BMP-4, 224,227 BMP-7, 224,228 BMP-12, and BMP-13. 225 Of these, BMP-1 and -2 have been shown to be particularly beneficial over other growth factors (e.g., other BMPs 225 or TGF-β1 229 ).…”

Section: Promise Of Tissue Engineering For Articular Cartilage Rementioning

confidence: 99%

The Role of Tissue Engineering in Articular Cartilage Repair and Regeneration

Zhang

Athanasiou

2009

Crit Rev Biomed Eng

407

352

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Articular cartilage repair and regeneration continue to be largely intractable due to the poor regenerative properties of this tissue. The field of articular cartilage tissue engineering, which aims to repair, regenerate, and/or improve injured or diseased articular cartilage functionality, has evoked intense interest and holds great potential for improving articular cartilage therapy. This review provides an overall description of the current state and progress in articular cartilage repair and regeneration. Traditional therapies and related problems are introduced. More importantly, a variety of promising cell sources, biocompatible tissue engineered scaffolds, scaffoldless techniques, growth factors, and mechanical stimuli used in current articular cartilage tissue engineering are reviewed. Finally, the technical and regulatory challenges of articular cartilage tissue engineering and possible future directions are discussed.

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Section: Promise Of Tissue Engineering For Articular Cartilage Rementioning

confidence: 99%

The Role of Tissue Engineering in Articular Cartilage Repair and Regeneration

Zhang

Athanasiou

2009

Crit Rev Biomed Eng

407

352

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“…Creating a full thickness cartilage defect in the experimental model, one factor that needs to be considered is the importance of subchondral bone healing as much as the neocartilaginous tissue. Many publications focus on PRP ability to stimulate bone formation [ 16 , 17 , 18 ] but it is impossible to state the influence of subchondral bone healing in the presence of PRP on final results reflected in the quality of the articular surface at the end of the follow-up period.…”

Section: ⧉ Discussionmentioning

confidence: 99%

Comparing PRP and bone marrow aspirate effects on cartilage defects associated with partial meniscectomy: a confocal microscopy study on animal model

Lazarescu

Romania²,

Văduva³

et al. 2021

Rom J Morphol Embryol

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Aim:The aim of our study was to assess the therapeutic effects of platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) in an animal knee lesion complex associating a large osteochondral defect and meniscal defect resulted from partial meniscectomy, a clinical situation that occurs quite often in orthopedic practice. Materials and Methods: Twenty-one male rabbits were included in the study, and all underwent initial surgery on the right knee to create the osteochondral defect on the internal femoral condyle, and remove the anterior horn of the internal meniscus, simulating a clinical situation. Rabbits were separated in three study groups: control, PRP group, in which three PRP injections were administered, and BMAC group, in which one single BMAC injection was administered. At the end of the six months follow-up period, knees were harvested and further analyzed using confocal microscopy and three-dimensional (3D) reconstruction of the articular surface. Results: Therapeutic groups had better results concerning articular surface remodeling and joint degeneration indicators in comparison to trauma group. Conclusions: Our results suggest that using post-operative regenerative therapies does improve final results concerning surface contact remodeling that was investigated using confocal microscopy and should be considered a valid treatment adjuvant in managing patients with this type of lesion complex, as it improves global joint outcome.

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“…The chondrocyte proliferation rate is a function of the initial number of cultured cells and the choice of appropriate articular cartilage layer as a cell source. The best results are obtained when chondrocytes are taken from the deeper zones and cultured at low cell densities [8].…”

Section: Introductionmentioning

confidence: 87%

The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regeneration

Augustyniak

Trzeciak

Richter

et al. 2014

International Orthopaedics (SICOT)

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Purpose The use of stem cells in regenerative medicine offers hope to treat numerous orthopaedic disorders, including articular cartilage defects. Although much research has been carried out on chondrogenesis, this complicated process is still not well understood and much more research is needed. The present review provides an overview of the stages of chondrogenesis and describes the effects of various growth factors, which act during the multiple steps involved in stem celldirected differentiation towards chondrocytes. Methods The current literature on stem cell-directed chondrogenesis, in particular the role of members of the transforming growth factor-β (TGF-β) superfamily-TGF-βs, bone morphogenetic proteins (BMPs) and fibroblast growth factors (FGFs)-is reviewed and discussed. Results Numerous studies have reported the chondrogenic potential of both adult-and embryonic-like stem cells and the role of growth factors in programming differentiation of these cells towards chondrocytes. Mesenchymal stem cells (MSCs) are adult multipotent stem cells, whereas induced pluripotent stem cells (iPSC) are reprogrammed pluripotent cells. Although better understanding of the processes involved in the development of cartilage tissues is necessary, both cell types may be of value in the clinical treatment of cartilage injuries or osteoarthritic cartilage lesions. Conclusions MSCs and iPSCs both present unique characteristics. However, at present, it is still unclear which cell type is most suitable in the treatment of cartilage injuries.

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Articular cartilage repair: the role of bone morphogenetic proteins

Cited by 43 publications

References 41 publications

The Role of Tissue Engineering in Articular Cartilage Repair and Regeneration

The Role of Tissue Engineering in Articular Cartilage Repair and Regeneration

Comparing PRP and bone marrow aspirate effects on cartilage defects associated with partial meniscectomy: a confocal microscopy study on animal model

The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regeneration

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