Artifacts in the Eeg of Schizophrenic Patients

Validity and Clinical Utility of Neuroleptic-Facilitated Electroencephalography in Psychotic Patients

“…Finally, subject-induced artifact time ratios were determined for pre-and post-drug tracings from the last 68 patients admitted to the study, according to the method of Bruck and Mc Neal. 26 Global ratings of treatment response in six major areas of dysfunction were completed at the end of four weeks or at the time of discharge, whichever occurred first. Final compilation of data was performed by the senior author using the following drug-EEG comparison groups: Group I (N=37): Normal EEG both before and during neuroleptic drug treatment Group II (N=18): Pre-treatment EEG either normal (N=14) or borderline abnormal due to mild diffuse slowing (N=4); EEG during neuroleptic drug treatment abnormal due to mild to moderate excesses of diffuse slow wave activity Group III (N=12): Pre-treatment EEG normal; EEG during neuroleptic drug treatment abnormal because of diffuse and/or focal epileptiform paroxysmal activity and transients (with or without diffuse slow waves) Group IV (N=16): Pre-treatment EEG borderline (N=6) or definitely abnormal (N=10) because of diffuse and/or focal epileptiform paroxysmal activity; EEG during neuroleptic drug treatment definitely abnormal because of accentuation of baseline paroxysmal dysrhythmias and transients (with or without @ 1978.VOL.9,NO,1 superimposed diffuse slowing) For non-parametric data, significance was established by use of a two-by-two chi-square test with Yates' correction.…”