Artificial Dermis as an Alternative for Coverage of Complex Scalp Defects following Excision of Malignant Tumors

Abstract

Artificial dermis can be used successfully for reconstruction of complex scalp defects following oncologic resection, offering minimal donor-site morbidity, expedient operative time, and when needed, temporary quality closure until final pathologic results are known. Integra skin may offer another option for definitive management of extensive full-thickness scalp defects.

Scalp Reconstruction Using Integra, an Alternative to Free Tissue Transfer—Case Report

“…Tumours with such rapid aggressive progression are treated with radical surgical resection, this remains the gold standard for treatment [1].…”

“…The scalp is extremely susceptible to developing skin cancers, associated with prolonged UV sunlight exposure and previous radiotherapy [1]. Surgical excision is the preferred treatment, but can pose reconstructive problems.…”

“…Surgical excision is the preferred treatment, but can pose reconstructive problems. Resection to bone and adjuvant radiation are often required to minimize risk of recurrence [1] [2].…”

“…Soft tissue coverage of post-irradiation calvarium stripped of periosteum is notoriously difficult, often resulting in skin graft failure, infections and chronic wounds. Patients with multiple comorbidities and contraindications to complex reconstructions are left with large areas of bare cranium requiring long-term regular dressings [1]- [3].…”

From Basic Wound Healing to Modern Skin Engineering

“…[56][57][58] Integra Bilayer Matrix Wound Dressing is a synthetic bilayer acellular skin substitute composed of an outer silastic sheet (epidermal analogue) with a matrix composed of bovine collagen and glycosaminoglycan (dermal analogue). [59][60][61][62][63][64][65][66][67] The silastic sheet provides temporary cover before skin grafting is performed.…”