Artificial Insemination Using Homologous Semen: A Review of 158 Cases

Dixon, Richard E.; Buttram, Veasy C.; Schum, Carolyn W.

doi:10.1016/s0015-0282(16)41894-7

Cited by 31 publications

(11 citation statements)

References 18 publications

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“…This is due to the epididymal content present in the first fraction. The spermatozoa rich fraction in the first split ejaculate was widely used for artificial insemination [2, 3, 5, 6, 7, 34]. …”

Section: Discussionmentioning

confidence: 99%

BASIC SCIENCE Split ejaculation study: semen parameters and calcium and magnesium in seminal plasma

Valsa¹,

Kp²,

Khan³

et al. 2012

cejurol4/2012

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ObjectivesMale infertility is on the rise. Artificial insemination is an option in many cases like oligozoospermia or oligoasthenozoospermia. Homologous insemination is helpful for some couples in whom sperm count is low. This study was aimed to understand the most suitable portion of split ejaculate for insemination and also the level of calcium and magnesium in each split.Materials and methodsA total number of 31 normal and clinically healthy adults participated in this study. They were instructed to maintain abstinence for 2-5 days prior to sample collection in three splits. Each split was evaluated as if it were a whole sample, following WHO criteria. Seminal plasma was separated. Calcium and magnesium levels were measured in seminal plasma and spermatozoa of each split.ResultsThe split ejaculate study revealed that the first portion contained a higher number of spermatozoa with better motility than the 2nd and 3rd splits. Similarly, the level of calcium and magnesium in seminal plasma and spermatozoa was greater in the first split, followed by 2nd and 3rd splits.ConclusionThe presented split ejaculate study has shown the first ejaculate as superior in quality in terms of total sperm count and percentage of active motility. The first split of ejaculation is recommended for homologous artificial insemination in case of oligozoospermia and oligoasthenozoospermia. This study has also shown that a major portion of two important elements, calcium and magnesium, is contributed by the prostate gland.

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Section: Discussionmentioning

confidence: 99%

BASIC SCIENCE Split ejaculation study: semen parameters and calcium and magnesium in seminal plasma

Valsa¹,

Kp²,

Khan³

et al. 2012

cejurol4/2012

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“…It is widely believed that the first portion of a split ejaculate has better fertilizing capacity than either the second portion (Amelar and Hotchkiss -1965) or the whole ejaculate (Amelar and Dubin -1975;Farris and Murphy -1960). Despite this belief, pregnancy rates after artificial insemination with husband semen (AIH) using the first portion of split ejaculates are not consistently better than pregnancy rates after AIH using the whole ejaculate (Amelar and Hotchkiss -1965;Moghissi et al -1977;Dixon et al -1976;Steiman and Taymor -1977;Parez-Pelaez and Cohen -1965;Mastroianni et al -1977).…”

Section: Introductionmentioning

confidence: 99%

The Split Ejaculate: Assessment of Fertility Potential Using Two in vitro Test Systems

et al. 2009

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Zusammenfassung: Von 12 normalen Miinnern (Gruppe A) und 8 infertilen Miinnern mit Oligozoospennie bei Spermatozoenkonzentrationen von weniger als 20 x lo6 /ml (Gruppe B) wurden Samenproben (Split-und vollstiindige Ejakulate) untersucht. M e Samenproben wurden untersucht mit StandardSamen Analyse, Rinderzervikalschleim-Penetrationsassay (CMPT) und in allen Fiillen mit hinreichendem Samen im Hmanspermatozoen-zonafreiesHamsterei-Penetrationsassay (SPA).

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“…Although Dixon et al [11] find successful homologous inseminations of almost 0-100% in their review of literature, and this percentage is reduced by Moghissi et al [12] to 56%, the extensive literature [13][14][15][16][17][18][19][20][21] proves that a comparison of the individual results can hardly stand critical analysis due to fact that the methods used and the patients selected are very different (determination of the time of ovulation, split ejaculate, centrifugal ejaculate, addition of cryosperm, classification of the semen parameters, number of insemination cycles, sterility of the man and/or woman), and the success solely depends on the indication of insemination.…”

Section: Discussionmentioning

confidence: 98%

“…The best results with AIH were achieved in cases of impotentia coeundi where the pregnancy rate was 62.5 to 85.7% [18,22,23], followed by a pregnancy rate of 32% [16] in the case of a negative postcoital test with normozoospermia and a rate of 18.75% [11] in the case of unexplained sterility as well as parvisemia with relatively high-quality ejaculate.…”

Section: Discussionmentioning

confidence: 99%

“…One problem of insemination therapy is clearly the fact that, whereas the optimal rate of insemination is only achieved after 4-5 cyles, after three frustrating insemination attempts, 50% [11] of the disappointed patients were no longer willing to agree continuing the treatment. Although it should be taken into account that in almost 60% of our female patients there were fertility-reducing factors, which could not be wholly eliminated by therapy, and none of the male patients could achieve lasting normozoospermia after therapy, in spite of prior systemic medication (mesterolone, nolvadex, kallikrein, solcoseryl, FSH and HCG) or operative therapy (varicocelectomy in the case of varicocele), our remarkably low pregnancy rate (3.81%) with homologous insemination using native ejaculates can well be compared with those of Dixon et al [11] and Speichinger and Mattox [15], if one considers the cases with the same indication individually.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pregnancy Rate after Homologous Insemination of Pathological Ejaculate both with and without the Addition of Kallikrein

Maier¹,

Grünberger

Binstorfer

et al. 1983

Gynecol Obstet Invest

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As part of a gynecological-andrological cooperation programme for the treatment of infertile marriages made by the 1st Department of Obstetrics and Gynecology and the Department of Urology, University of Vienna Medical School, the pregnancy rates achieved through 1,269 homologous inseminations of pathological ejaculates (according to Elliason’s classification) both with and without addition of kallikrein was analysed retrospectively. In the case of 131 married couples, only 5 pregnancies occurrred without the addition of kallikrein, and where kallikrein was used, there were also 5 pregnancies in 75 couples (6.66%). No conception occurred when cryoejaculate was used in addition. There were altogether 11 cases of spontaneous pregnancies. Conception could only be induced if an ejaculate of relatively high quality with a spermatozoa count of more than 12 million/ml and a 2-hour motility of more than 28% was used for insemination. The problems associated with homologous insemination with pathological ejaculate are being discussed.

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Artificial Insemination Using Homologous Semen: A Review of 158 Cases

Cited by 31 publications

References 18 publications

BASIC SCIENCE Split ejaculation study: semen parameters and calcium and magnesium in seminal plasma

BASIC SCIENCE Split ejaculation study: semen parameters and calcium and magnesium in seminal plasma

The Split Ejaculate: Assessment of Fertility Potential Using Two in vitro Test Systems

Pregnancy Rate after Homologous Insemination of Pathological Ejaculate both with and without the Addition of Kallikrein

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