Artificial intelligence application versus physical therapist for squat evaluation: a randomized controlled trial

Luna, Alessandro; Casertano, Lorenzo; Timmerberg, Jean Fitzpatrick; O’Neil, Margaret E.; Machowsky, Jason; Leu, Cheng-Shiun; Lin, Jie; Fang, Zhiqian; Douglas, William; Agrawal, Sunil K.

doi:10.1038/s41598-021-97343-y

Cited by 14 publications

(8 citation statements)

References 29 publications

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“…Quadro 1 -Estudos selecionados, considerando suas características em comum: ano de publicação, autor, título, objetivo, tipo de estudo e principais resultados Luna, A. et al, 2021 Artificial intelligence application versus physical therapist for squat evaluation: a randomized controlled trial.…”

Section: Resultados Caracterização Dos Resultadosunclassified

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Os labirintos da gestão, práticas, modelos de protocolo e financiamento em saúde

Jorge¹,

Moreira²,

Souza³

et al. 2022

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Os labirintos da gestão em saúde e suas práticas, modelos de protocolos e financiamento em saúde e suas interfaces convocam o leitor a adentrar um novo universo da gestão em saúde pós-pandemia que desestruturou os programas e estratégias montadas no combate das doenças endêmicas do Brasil, potencializando a disseminação de patologias psíquicas em proporções epidêmicas, além de vivência da reemergência de patologias erradicadas e/ou controladas. As entranhas do sistema de saúde têm nos apresentado rompimentos seculares em diversas áreas, em que vários fatores levam-nos a labirintos temerosos, como no caso da saúde mental, que vem sofrendo retrocessos importantes na forma de assistência, inclusive com incentivo ao retorno dos hospitais psiquiátricos. Os sistemas de informações do Ministério da Saúde (MS) vêm constantemente sofrendo hackeamentos, o que deixa todo gestor em constante receio de perder seus dados. Sabe-se que os sistemas de informação em saúde (SIS) sempre foram orgulho de nossos gestores, como também fonte de pesquisa e aparato para os repasses financeiros.

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Section: Resultados Caracterização Dos Resultadosunclassified

“…Desta forma, foram identificados como ferramentas tecnológicas: inteligência artificial (MILNE-IVES et al, 2020;VOURGANAS;STANKOVIC;STANKOVIC, 2020;LUNA et al, 2021).…”

Section: Caracterização Geral Dos Resultadosunclassified

Os labirintos da gestão, práticas, modelos de protocolo e financiamento em saúde

Jorge¹,

Moreira²,

Souza³

et al. 2022

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“…Content plays an important role in determining the therapeutic effect of DTx; to induce patients to take continuous medication (participation) and increase the therapeutic effect, the provisional content and method are determined by considering the target indication, patient's age, and sociocultural characteristics. Content is often developed based on the experience and expertise of clinicians; however, recently, cases of applying artificial intelligence to treatment contents or treatment guides have been reported 43,44 , thus continuous attention is required.…”

Section: Discussionmentioning

confidence: 99%

Digital therapeutics from bench to bedside

2023

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As a new therapeutic technique based on digital technology, the commercialization and clinical application of digital therapeutics (DTx) are increasing, and the demand for expansion to new clinical fields is remarkably high. However, the use of DTx as a general medical component is still ambiguous, and this ambiguity may be owing to a lack of consensus on a definition, in addition to insufficiencies in research and development, clinical trials, standardization of regulatory frameworks, and technological maturity. In this study, we conduct an in-depth investigation and analysis of definitions, clinical trials, commercial products, and the regulatory status related to DTx using published literature, ClinicalTrials.gov, and web pages of regulatory and private organizations in several countries. Subsequently, we suggest the necessity and considerations for international agreements on the definition and characteristics of DTx, focusing on the commercialization characteristics. In addition, we discuss the status and considerations of clinical research, key technology factors, and the direction of regulatory developments. In conclusion, for the successful settlement of DTx, real-world evidence-based validation should be strengthened by establishing a cooperative system between researchers, manufacturers, and governments, and there should be effective technologies and regulatory systems for overcoming engagement barriers of DTx.

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“…AI and other innovative technologies and methods provide solutions. In a squat evaluation experiment, the calculation sensitivity of AI can intelligently identify the correct squat posture and improve the accuracy of the evaluation link [71]. In phase I/II clinical trials, researchers propose a novel Bayesian adaptive to address the issue of late-onset competing risk outcomes [72].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic efficacy of Xingnaojing injection for ischemic stroke: A systematic review and meta-analysis of randomized controlled trials

Xiao

Xue

Huang

et al. 2023

Preprint

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Background Stroke is one of the leading causes of human disability and death, and ischemic stroke constitutes 69.6–70.8% of all strokes. Xingnaojing injection (XNJ) is used to treat stroke in China, but its specific mechanism is not completely clear. This meta-analysis evaluated the clinical efficacy and safety of XNJ for ischemic stroke treatment and showed that XNJ could inhibit the inflammatory response of stroke patients. Methods Nine databases were searched from inception to 20 July 2021, following the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) criteria for systematic reviews and meta-analyses. Two reviewers independently screened studies, extracted data of interest, and assessed the risk of bias. Meta-regression and subgroup analysis evaluated the heterogeneity and its impact on the results. Results In total, 24 separate RCTs, which were all conducted in China and published from 2008 to 2021, involved 2522 patients with ischemic stroke. XNJ combined with CT were better than CT alone in overall response rate (RR = 1.15, 95%CI [1.12, 1.19], p = 0.00), NIHSS score (WMD=-3.38, 95%CI [-4.35, -2.40], p = 0.00), Barthel index (WMD = 8.19, 95%CI [5.70, 10.68], p = 0.00), TNF-α (SMD=-2.75, 95%CI [-3.67, -1.84], p = 0.00), IL-6 (SMD=-2.56, 95%CI [-3.34, -1.70], p = 0.00), and CRP (SMD=-1.30, 95%CI [-1.58, -1.01], p = 0.00). Meta-analysis of safety showed that the data were not statistically significant (p = 0.21). For adverse events with low certainty evidence, safety needs further verification. Conclusions Based on the results, XNJ combined with CT likely improved clinical symptoms compared with CT alone. The mechanism may be related to the neuroprotective and anti-inflammatory effects. More high-quality, multicenter, and large-sample RCTs should be tested and verified in the future.

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Artificial intelligence application versus physical therapist for squat evaluation: a randomized controlled trial

Cited by 14 publications

References 29 publications

Os labirintos da gestão, práticas, modelos de protocolo e financiamento em saúde

Os labirintos da gestão, práticas, modelos de protocolo e financiamento em saúde

Digital therapeutics from bench to bedside

Therapeutic efficacy of Xingnaojing injection for ischemic stroke: A systematic review and meta-analysis of randomized controlled trials

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