Artificial periosteum in bone defect repair—A review

Wang, Quan; Xu, Jianzhong; Jin, Haiming; Zheng, Wenhao; Zhang, Xiaolei; Huang, Yixing; Qian, Zhiyong

doi:10.1016/j.cclet.2017.07.011

Cited by 44 publications

(30 citation statements)

References 79 publications

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“… 6 , 49 The porous structure is beneficial for rapid diffusion of nutrients throughout the network, improving the efficacy in cell attachment, proliferation, and migration. 7 , 50 , 51 …”

Section: Resultsmentioning

confidence: 99%

Gelatin-Based Hydrogels Blended with Gellan as an Injectable Wound Dressing

et al. 2018

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Injectable scaffolds are of great interests for skin regeneration because they can fill irregularly shaped defects through minimally invasive surgical treatments. In this study, an injectable hydrogel from biopolymers is developed and its application as wound dressings is examined. Gelatin-based hydrogels were successfully prepared at body temperature upon blending with low content of gellan, and the synergetic effect on the gel formation was carefully characterized through rheological methods. The electrostatic complexation between gelatin and gellan was confirmed to contribute a continuous hydrogel network. The obtained blend hydrogel demonstrates remarkable shear-thinning and self-recovering properties. For antibacterial purpose, tannic acid was incorporated into the blend hydrogel. In addition, tannic acid-loaded blend hydrogel was verified to accelerate the wound healing on the mice model, significantly than the control groups. Thus, this paper presents a facile approach without chemical modification to construct injectable gelatin-based hydrogels, which have great potential as a wound dressing or tissue scaffold at body temperature.

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“… 6 , 49 The porous structure is beneficial for rapid diffusion of nutrients throughout the network, improving the efficacy in cell attachment, proliferation, and migration. 7 , 50 , 51 …”

Section: Resultsmentioning

confidence: 99%

Gelatin-Based Hydrogels Blended with Gellan as an Injectable Wound Dressing

et al. 2018

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“…Different strategies have been applied to produce composites for bone repair using different calcium phosphates, some of which are associated with bone morphogenetic protein. − The literature shows that nHAp is bioactive and biocompatible, but its physicochemical properties lead to a smaller surface area and bioactivity than the nanocomposites prepared herein . The nHAp/GNR (containing 2 wt %/wt of GNR) nanocomposite produces a 3.4 nm pore diameter (Figure S2d), which is a very interesting result that may contribute to enhanced bone neoformation compared to nHAp (pore diameter of 6.8, Figure S2d).…”

Section: Resultsmentioning

confidence: 99%

Nanohydroxyapatite/Graphene Nanoribbons Nanocomposites Induce in Vitro Osteogenesis and Promote in Vivo Bone Neoformation

Medeiros

Oliveira

Carvalho

et al. 2018

ACS Biomater. Sci. Eng.

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Nanomaterials based on graphene oxide nanoribbons (GNR) and nanohydroxyapatite (nHAp) serve as attractive materials for bone tissue engineering. Herein, we evaluated the potential of nHAp/GNR toward in vitro analysis of specific genes related to osteogenesis and in vivo bone regeneration using animal model. Three different concentrations of nHAp/GNR composites were analyzed in vitro using a cytotoxicity assay, and osteogenic potential was determined by ALP, OPN, OCN, COL1, and RUNX2 genes and alkaline phosphatase assays. In vivo bone neoformation using a well-established in vivo rat tibia defect model was used to confirm the efficiency of the optimized composite. The scaffolds were nontoxic, and the osteogenesis process was dose-dependent (at 200 μg mL–1 of nHAp/GNR) compared to controls. The in vivo results showed higher bone neoformation after 15 days of nHAp/GNR implantation compared to all groups. After 21 days, both nHAp/GNR composites showed better lamellar bone formation compared to control. We attributed this enhanced bone neoformation to the high bioactivity and surface area presented by nHAp/GNR composites, which was systematically evaluated in previous studies. These new in vivo results suggest that nHAp/GNR composites can be exploited for a range of strategies for the improved development of novel dental and orthopedic bone grafts to accelerate bone regeneration.

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“…In general, bone defects caused by trauma are often accompanied by periosteal damage. Periosteum is consisted of fibrous layer and osteogenic layer [5][6][7]. Usually, the fibrous layer is responsible for providing nourishment to cells via its capillary network and whilst original cells attached on the bone surface will continue to differentiate [8,9].…”

Section: Introductionmentioning

confidence: 99%

Electrospun highly porous poly(L-lactic acid)-dopamine-SiO2 fibrous membrane for bone regeneration

Wang

Zhang

et al. 2020

Materials Science and Engineering: C

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Electrospinning has been widely used to fabricate polymer fibrous scaffolds for bone tissue engineering because of their highly porous structures. In order to improve the biocompatibility of polymer scaffolds, some nano particles have been introduced into electrospun fibres. For example, silica nanoparticles (SiNPs), with high surface area and good biocompatibility, have been used for bone tissue engineering for better bone cell attachment. In this work, porous poly(L-lactic acid) (PLLA) fibrous membrane with high surface area was fabricated by electrospinning and posttreatment process. The membrane can serve as substrates of SiNPs for bone tissue engineering. Dopamine (DOP) was applied to modify the surface of PLLA fibres, which improved the coating strength of SiNPs on PLLA fibres. SiNP coating significantly improved the mechanical properties Manuscript File Click here to view linked References 2 and hydrophilicity of PLLA/DOP/SiNP composite membranes. As a result of SiNPs coating, PLLA/DOP/SiNP membrane exhibited better cellular biocompatibility, more cell attachment and proliferation. These results demonstrate that porous PLLA/DOP/SiNP composite membrane with high surface area has high potential for periosteum in the field of bone regeneration applications.

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Artificial periosteum in bone defect repair—A review

Cited by 44 publications

References 79 publications

Gelatin-Based Hydrogels Blended with Gellan as an Injectable Wound Dressing

Gelatin-Based Hydrogels Blended with Gellan as an Injectable Wound Dressing

Nanohydroxyapatite/Graphene Nanoribbons Nanocomposites Induce in Vitro Osteogenesis and Promote in Vivo Bone Neoformation

Electrospun highly porous poly(L-lactic acid)-dopamine-SiO2 fibrous membrane for bone regeneration

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