Artrite reumatoide e doença cardiovascular: o que sabemos e o que podemos fazer pelo paciente na atualidade?

Soeiro, Alexandre de Matos; Haddad, Marcela Filié; Almeida, Maria Carolina Feres de; Ruppert, Aline Domingos Pinto; Serrano, Carlos

doi:10.1016/j.repc.2012.01.005

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…31,32 However, there are also reports describing the so-called “lipid paradox” in inflammatory diseases, mainly rheumatoid arthritis, marked by a significant decrease in LDL-cholesterol and TC levels 3-5 years before the onset of signs of the disease. 34,35 There also evidences of possible influence of pharmacological interventions on lipid profile of these patients. 36…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Risk in Psoriasis Patients: Clinical, Functional and Morphological Parameters

Oliveira

Simões

et al. 2019

Arquivos Brasileiros De Cardiologia

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BackgroundPsoriasis correlates with metabolic disorders, early atheromatosis and increased cardiovascular risk.ObjectivesTo assess markers of cardiovascular disease in psoriatic patients.MethodsCross-sectional, observational study involving 11 psoriatic participants and 33 controls. Anthropometric, biochemical, hemodynamic and imaging parameters were evaluated. Arterial stiffness was assessed by oscillometric measurement of the brachial artery. Intima-media thickness (IMT) and left ventricular diastolic function were assessed by Doppler echography and echocardiography. Between-group comparisons of numerical variables were performed by the Student’s t-test or Wilcoxon Mann-Whitney test for independent samples. Significance level was set at 5%.ResultsPsoriatic patients showed increased pulse wave velocity (PWV) (9.1 ± 1.8 vs 8.0 ± 2 m/s, p = 0.033), IMT of the left common carotid artery (p = 0.018) and a higher percentage of patients above the 75th percentile according to the ELSA table when compared with controls (54.5 vs 18.2%, p = 0.045). Psoriatic patients also showed an increase in peripheral/central systolic blood pressure (137.1 ± 13.2 vs 122.3 ± 11.6 mmHg, p = 0.004)/(127 ± 13 vs 112.5 ± 10.4 mmHg, p = 0.005), peripheral/central diastolic blood pressure (89.9 ± 8.9 vs 82.2 ± 8, p = 0.022)/(91 ± 9.3 vs 82.2 ± 8.3, p = 0.014), total cholesterol (252 ± 43.5 vs 198 ± 39.8 mg/dL, p < 0.001), LDL cholesterol (167 ± 24 vs 118 ± 40.8 mg/dL, p < 0.001) and C-reactive protein (7.6 ± 35.4 vs 1 ± 1.2 mg/L p < 0.001) compared with controls.ConclusionPsoriasis patients show increased PWV, IMT, peripheral and central blood pressures, and serum cholesterol and C-reactive protein levels, denoting a higher cardiovascular risk.

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