Arzneimittelanalysen mittels polarographischer Methoden, 33. Mitt.: Elektroanalytische Untersuchungen an einem neuen Benzodiazepin: [6‐(2‐Chlorphenyl)‐2‐(4‐methyl‐1‐piperazinylmethylen) ‐8‐nitro‐2H‐imidazol[1,2‐a][1,4]benzodiazepin‐1(4H)‐on (VO) (Loprazolam, 1)] und Gehaltsbestimmung seiner Arzneiformen

Abstract

Loprazolam (1) is a tricyclic benzodiazepine containing a new butazadiene moiety, which has not been investigated by polarography up to now. 1 is reduced in three waves at a DME over the whole pH-region. In BRP (pH 2-9) 10 electrons are consumed in this process. The first step is suitable for the determination of 1 in Loprazolam tablets containing 1 or 2 mg. These tablets are on the pharmaceutical market in several European countries. The mechanism of the electrode process will be reported in the communication XXXIV.