As nanopartículas como ferramentas biológicas: uma revisão exploratória

Abstract

Nanotechnology is a multidisciplinary science capable of developing great advances in the most diverse areas. The interest in the use of nanoparticles (NPs) in biological applications is notorious, due to their physicochemical properties. This study aims to present the biological applications of nanoparticles in modern science, in order to show the prospects for advancement in the area of nanotechnology aimed at biological applications. For this, an exploratory bibliographic review of a qualitative nature was carried out based on public productions between the years 2010 to 2020. The acquisitions of the works were carried out on the platforms Nature, Science, Scielo, Science Direct, Web of Science, Google Academic and Latindex. A general approach on the properties of nanoparticles was carried out, emphasizing their biological applications. It can be seen that the main areas of biological application of nanoparticles are the production of drugs and detection of diagnoses at the cellular level. In addition, it is clear that the gold nanoparticle is the most used in current studies. Thus, the present study aims to serve as a subsidy for researchers in the nanotechnology area, presenting in an exploratory and descriptive way the studies published in the last decade.

Síntese e caracterização de nanopartículas de óxido de ferro: Uma proposta de atividade experimental

“…Considerada uma ciência multidisciplinar, a nanotecnologia é capaz de proporcionar grandes avanços nas mais diversas áreas (Melo, Souza, Carvalho, Bezerra, & Costa, 2020). As pesquisas no universo nanométrico nem sempre estão relacionados ao desenvolvimento de novos materiais e muitas vezes focam em materiais já conhecidos, uma vez que em escala nanométrica os materiais dispõem de propriedades físicas e químicas diferenciadas (Pereira, Honório, & Sannomiya, 2010).…”

Gold nanoparticles associated with temozolomide for glioblastoma Multiforme Treatment

“…Using metallic nanoparticles is also one possibility very explored in new studies, which include the development enhancers of the radiotherapy effect. These nanoparticles can be associated with several chemotherapeutic agents in search of better results in cancer treatments, and they can be used in target therapy, decreasing toxicity in normal tissues, increasing the drug's half-life, protecting the drug from degradation, renal clearance, and increasing the solubility, providing the possibility of dose reduction and, fewer side effect (Melo et al, 2020;Pérez-Herrero et al, 2018). In this study, TMZ, TMZ plus AuNPs and associated with radiotherapy will be analyzed.…”

Uso de formulações lipossômicas para entrega controlada de fármacos antineoplásicos

“…A multidisciplinaridade da nanotecnologia possibilita inúmeros avanços em áreas diversas, sendo evidente o interesse da sua utilização em aplicações biológicas, como na produção de medicamentos (Melo, Souza, Carvalho, Bezerra & Costa, 2020). A descoberta de novos fármacos usados para terapia antineoplásica tem avançado, mas ainda existe a necessidade de desenvolvimento de medicamentos inovadores capazes de serem direcionados a alvos específicos e entregar de forma controlada os agentes terapêuticos a alvos moleculares localizados nas células neoplásicas (Li, Di, Li, Yang, & Nie, 2019).…”