This method of selective surveillance for nosocomial infections based on risk factors identified by physicians demonstrated excellent predictive value and overall accuracy and may be of use to other hospitals that lack a nursing care plan book such as the Kardex. The relative frequency of nosocomial infections significantly exceeded the rates reported from hospitals in developed countries.
The callus and roots developed from the hypocotyl and cotyledon explants of the germinating seeds of Calotropis procera were grown in culture, and the proteins isolated from them (CP and RP) were evaluated for their efficacy in inhibiting edema formation induced by sub-plantar injection of carrageenan in the hind paw of rat. Intravenous administration of both CP and RP 30 min before inducing inflammation produced a dose-dependent inhibition of edema formation at 1 and 5 mg/kg doses. The extents of inhibition with these proteins ranged between 40 and 70 % at the doses included while the anti-inflammatory drug diclofenac produced 50 to 60 % inhibition at 5 mg/kg dose. The inhibitory effect with these proteins was accompanied by a dose-dependent reduction in the tissue levels of inflammatory mediators, tumor necrosis factor alpha (TNF-α) and prostaglandin E2 (PGE2), and oxidative stress markers namely glutathione and thiobarbituric acid-reactive substances and maintenance of tissue architecture. The present study shows that the proteins isolated from the differentiated and undifferentiated tissues derived from the germinating seeds have therapeutic application in the treatment of inflammatory conditions, and these tissues could be used as an alternative source to minimize variability of plant-derived formulations.
Nanotechnology is a multidisciplinary science capable of developing great advances in the most diverse areas. The interest in the use of nanoparticles (NPs) in biological applications is notorious, due to their physicochemical properties. This study aims to present the biological applications of nanoparticles in modern science, in order to show the prospects for advancement in the area of nanotechnology aimed at biological applications. For this, an exploratory bibliographic review of a qualitative nature was carried out based on public productions between the years 2010 to 2020. The acquisitions of the works were carried out on the platforms Nature, Science, Scielo, Science Direct, Web of Science, Google Academic and Latindex. A general approach on the properties of nanoparticles was carried out, emphasizing their biological applications. It can be seen that the main areas of biological application of nanoparticles are the production of drugs and detection of diagnoses at the cellular level. In addition, it is clear that the gold nanoparticle is the most used in current studies. Thus, the present study aims to serve as a subsidy for researchers in the nanotechnology area, presenting in an exploratory and descriptive way the studies published in the last decade.
This method of selective surveillance for nosocomial infections based on risk factors identified by physicians demonstrated excellent predictive value and overall accuracy and may be of use to other hospitals that lack a nursing care plan book such as the Kardex. The relative frequency of nosocomial infections significantly exceeded the rates reported from hospitals in developed countries.
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