AS1411 aptamer-targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast tumor-bearing Mice

Ghahremani, Fatemeh; Kefayat, Amirhosein; Shahbazi‐Gahrouei, Daryoush; Motaghi, Hasan; Mehrgardi, Masoud A.; Haghjooy-Javanmard, Shaghayegh

doi:10.2217/nnm-2018-0180

Cited by 60 publications

(52 citation statements)

References 49 publications

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“…A gold nanocluster conjugate of the AS1411 aptamer enhanced the efficacy of radiation therapy in breast tumor-bearing mice. Importantly, the authors reported a specific enrichment of the radiosensitizing gold nanoclusters in the breast tumors and a significant increase in the mean survival times of the animals [75]. Analogously, the combination of silver nanoparticles with polyethylene glycol (PEG)-functionalized AS1411 aptamer improved the outcome of radiation therapy in preclinical glioma models.…”

Section: Aptamers With Metal (Nano-)formulationsmentioning

confidence: 97%

Aptamers: a novel targeted theranostic platform for pancreatic ductal adenocarcinoma

Maier

et al. 2020

Radiat Oncol

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Pancreatic ductal adenocarcinoma (PDAC) is an extremely challenging disease with a high mortality rate and a short overall survival time. The poor prognosis can be explained by aggressive tumor growth, late diagnosis, and therapy resistance. Consistent efforts have been made focusing on early tumor detection and novel drug development. Various strategies aim at increasing target specificity or local enrichment of chemotherapeutics as well as imaging agents in tumor tissue. Aptamers have the potential to provide early detection and permit anti-cancer therapy with significantly reduced side effects. These molecules are in-vitro selected single-stranded oligonucleotides that form stable threedimensional structures. They are capable of binding to a variety of molecular targets with high affinity and specificity. Several properties such as high binding affinity, the in vitro chemical process of selection, a variety of chemical modifications of molecular platforms for diverse function, non-immunoreactivity, modification of bioavailability, and manipulation of pharmacokinetics make aptamers attractive targets compared to conventional cell-specific ligands. To explore the potential of aptamers for early diagnosis and targeted therapy of PDAC-as single agents and in combination with radiotherapy-we summarize the generation process of aptamers and their application as biosensors, biomarker detection tools, targeted imaging tracers, and drug-delivery carriers. We are furthermore discussing the current implementation aptamers in clinical trials, their limitations and possible future utilization.

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Section: Aptamers With Metal (Nano-)formulationsmentioning

confidence: 97%

Aptamers: a novel targeted theranostic platform for pancreatic ductal adenocarcinoma

Maier

et al. 2020

Radiat Oncol

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“…Aptamer-based nanostructures have also been widely used in medicine, biology, and nanoelectronics due to the high stability, as shown in Table 1. The AS1411 aptamer conjugated with gold nanoclusters was tested in mice cancer cells and demonstrated to be a good radiosensitizer (Ghahremani et al 2018). Through cell-SELEX, the JHIT2 aptamer was selected and labeled with FAM and iodine-131 to detect human hepatoma cell line HepG2 by a fluorescent signal (Zhang et al 2020).…”

Section: Aptamers Applicationsmentioning

confidence: 99%

An overview and future prospects on aptamers for food safety

Schmitz

Valério

Oliveira

et al. 2020

Appl Microbiol Biotechnol

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Introduction Many bacteria are responsible for infections in humans and plants, being found in vegetables, water, and medical devices. Most bacterial detection methods are time-consuming and take days to give the result. Aptamers are a promising alternative for a quick and reliable measurement technique to detect bacteria present in food products. Selected aptamers are DNA or RNA oligonucleotides that can bind with bacteria or other molecules with affinity and specificity for the target cells by the SELEX or cell-SELEX technique. This method is based on some rounds to remove the non-ligand oligonucleotides, leaving the aptamers specific to bind to the selected bacteria. Compared with conventional methodologies, the detection approach using aptamers is a rapid, low-cost form of analysis. Objective This review summarizes obtention methods and applications of aptamers in the food industry and biotechnology. Besides, different techniques with aptamers are presented, which enable more effective target detection. Conclusion Applications of aptamers as biosensors, or the association of aptamers with nanomaterials, may be employed in analyses by colorimetric, fluorescence, or electrical devices. Additionally, more efficient ways of sample preparation are presented, which can support food safety to provide human health, with a low-cost method for contaminant detection. Key points • Aptamers are promising for detecting contaminants outbreaks. • Studies are needed to identify aptamers for different targets.

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“…In another study, he has introduced SPIONs conjugated J591 Mab and their experiments confirmed the high potential of the nanoprobe as a specific MRI contrast agent for the detection of PSMA-expressing prostate cancer. [36]…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

“…Due to extensive applications of magnetic iron oxide nanoparticles in biomedicine, many studies were performed under in vitro conditions and their cytotoxicity was investigated. [536] In this way, Keshtkar et al . [5] prepared a novel aptamer-conjugated nanoparticle using AS1411 aptamer which was conjugated to Fe 3 O 4 @Au nanoparticles on mouse mammary carcinoma (4T1) cells that overexpressed nucleolin.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Medical imaging modalities using nanoprobes for cancer diagnosis: A literature review on recent findings

Shahbazi‐Gahrouei

Khaniabadi

et al. 2019

J Res Med Sci

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Medical imaging modalities are used for different types of cancer detection and diagnosis. Recently, there have been a lot of studies on developing novel nanoparticles as new medical imaging contrast agents for the early detection of cancer. The aim of this review article is to categorize the medical imaging modalities accompanying with using nanoparticles to improve potential imaging for cancer detection and hence valuable therapy in the future. Nowadays, nanoparticles are becoming potentially transformative tools for cancer detection for a wide range of imaging modalities, including computed tomography (CT), magnetic resonance imaging, single photon emission CT, positron emission tomography, ultrasound, and optical imaging. The study results seen in the recent literature provided and discussed the diagnostic performance of imaging modalities for cancer detections and their future directions. With knowledge of the correlation between the application of nanoparticles and medical imaging modalities and with the development of targeted contrast agents or nanoprobes, they may provide better cancer diagnosis in the future.

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AS1411 aptamer-targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast tumor-bearing Mice

Cited by 60 publications

References 49 publications

Aptamers: a novel targeted theranostic platform for pancreatic ductal adenocarcinoma

Aptamers: a novel targeted theranostic platform for pancreatic ductal adenocarcinoma

An overview and future prospects on aptamers for food safety

Medical imaging modalities using nanoprobes for cancer diagnosis: A literature review on recent findings

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