Asbestos-related lung cancer mortality in Piedmont, Italy

Martuzzi, Marco; Comba, Pietro; Santis, Marco De; Iavarone, Ivano; Paola, Maurizio Di; Mastrantonio, Marina; Pirastu, Roberta

doi:10.1002/(sici)1097-0274(199806)33:6<565::aid-ajim7>3.0.co;2-p

Cited by 19 publications

(12 citation statements)

References 24 publications

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“…In Italy, a study of LC mortality in an asbestos cementmanufacturing town (Casale Monferrato) reported an attributable risk among exposed of 67.5% for men and 51.3% for women, and among the general population (not occupationally exposed) of 18.3% for men and 10.1% for women (Magnani et al, 1997). An ecological study in Piedmont found that for a unit increase in the relative risk of pleural neoplasm, a 2.5% increase in LC mortality was estimated and 3.9% LC deaths were attributable to residence in municipalities with high pleural neoplasm mortality (proxy of asbestos exposure) (Martuzzi et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Magnitude of asbestos-related lung cancer mortality in Italy

Marinaccio¹,

Scarselli²,

Binazzi³

et al. 2008

Br J Cancer

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Section: Discussionmentioning

confidence: 99%

Magnitude of asbestos-related lung cancer mortality in Italy

Marinaccio¹,

Scarselli²,

Binazzi³

et al. 2008

Br J Cancer

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“…Its goal is to provide up-todate, clear information to both policy-makers and stakeholders to minimize human exposure to potentially harmful materials. When inhaled, asbestos fibers may give rise to either non-tumor diseases or malignant tumors in the lungs (Martuzzi et al 1999) and pleura (Mastrantonio et al 2002). Particular attention should be paid to the effects of asbestos on the rise of pleural mesothelioma (Bignon et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Crystal chemical and structural characterization of fibrous tremolite from Susa Valley, Italy, with comments on potential harmful effects on human health

Ballirano

Andreozzi

Belardi

2008

American Mineralogist

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This study is part of a broad research project devoted to the “amphibole fibers environmental problem” as related to the proposed excavation of the Susa Valley railway tunnel. In this locality, tunnel excavations are planned through metamorphic formations containing amphibole asbestos minerals, and this may give rise to worker health and public environmental issues. The Susa Valley tremolite shows a marked fibrous character, a small reduction of fiber size under grinding, and a consistent increase of the surface area. From the toxicological point of view, such tremolite fibers have been shown to be very effective in the generation of reactive oxygen species. They exhibit a very high cellular reactivity as a consequence of their morphology, structure, and crystal chemistry. Results of combined electron microprobe analysis, Mössbauer spectroscopy, and parallel-beam X-ray powder diffraction are reported for fibrous tremolite from a serpentine-schist from the “Unità Oceanica della Bassa Val di Susa” collected near Condove, Susa Valley, Italy. Data indicate that Fe2+ (84% of Fetot) is located at both the (M1 + M3) and M2 sites and that Fe3+ is at M2, in an approximate 3:2:1 ratio, respectively. No evidence of a split M4 site has been observed. The presence of M1+M3Fe2+ is confirmed by FTIR spectroscopy to be distributed 70% at M1 and 30% at M3. Both the composition (Ca1.95K0.01Na0.05)Σ2.01(VIAl0.01Fe3+0.02Fe2+0.11Mg4.84Mn0.02)Σ5.00Si8.00O22(OH1.96F0.03Cl0.01)Σ2.00 and the cell volume 907.37(1) Å3 of the fibers are close to those expected for end-member (Ca/Mg = 2/5) tremolite

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“…Several questions remain open, but many epidemiological studies have demonstrated the importance of air pollution as a risk factor for mortality and morbidity [1][2][3][4][5][6][7][8][9]. For several specific health endpoints and pollutants, the associations have been quantified and concentration-response relationships have been characterised.…”

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confidence: 99%

Health impact assessment of air pollution: providing further evidence for public health action

Martuzzi

Krzyżanowski²,

Bertollini³

2003

Eur Respir J

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Many epidemiological studies have demonstrated the importance of air pollution as a risk factor and characterised dose-response relationships between health endpoints and pollutants.The association between particulate matter (PM) and health is generally regarded as causal, and a nonthreshold linear relationship with, for example, mortality and hospital admission has been observed in several settings.The ubiquitous PM air pollution is likely to have a large overall impact on human health, even if risks are relatively small. There have recently been a large number of papers reporting quantitative estimations of the health impact of PM on health, as measured by the proportion of excess events that are attributable to PM exposures in the general population, mainly in industrialised countries. For example, in the eight largest Italian cities it has been estimated that concentrations beyond 30 mg?m -3 are responsible for about 3,500 extra deaths per year. A similar study has been carried out for France, Austria and Switzerland.These evaluations fill a knowledge gap between the laboratory and clinical studies on the pathophysiological mechanisms, the epidemiological research on the nature and strength of the association at the population level, and the risk management needs for developing appropriate preventive policies.Some The scientific evidence on the health effects of ambient air pollution has been growing in recent years. Several questions remain open, but many epidemiological studies have demonstrated the importance of air pollution as a risk factor for mortality and morbidity [1][2][3][4][5][6][7][8][9]. For several specific health endpoints and pollutants, the associations have been quantified and concentration-response relationships have been characterised. Among these pollutants, the role of suspended particulate matter (PM) has been especially investigated with regard to its short-and long-term effects on mortality and morbidity. Most of the scientific evidence available to date concerns PM10 and PM2.5 (particles with a 50% cut-off aerodynamic diameter ofv10 and v2.5 mm, respectively), although the role of finer particles is of increasing interest. This evidence has prompted the World Health Organization (WHO) to include air pollution and its health effects in its agenda [10][11][12].Although the biological mechanism of action is not yet fully understood, the association between PM and health is generally regarded as causal [13], and a nonthreshold concentrationresponse relationship with, for example, mortality and hospital admission has been observed in several settings. Cohort studies conducted in the USA found increase in total and cardio-respiratory mortality in populations of cities with higher long-term mean PM10 concentrations [14][15][16]. Shortterm studies have demonstrated effects occurring shortly after elevated concentration days: hospital admission [17][18][19][20][21], incidence of new cases of bronchitis and occurrence of respiratory symptoms and asthma exacerbation [22][23][24], fo...

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Asbestos-related lung cancer mortality in Piedmont, Italy

Cited by 19 publications

References 24 publications

Magnitude of asbestos-related lung cancer mortality in Italy

Magnitude of asbestos-related lung cancer mortality in Italy

Crystal chemical and structural characterization of fibrous tremolite from Susa Valley, Italy, with comments on potential harmful effects on human health

Health impact assessment of air pollution: providing further evidence for public health action

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