Asbestosis and Catalase Genetic Polymorphism

Franko, Alenka; Dolžan, Vita; Arnerić, Niko; Dodic-Fikfak, Metoda

doi:10.2478/10004-1254-59-2008-1907

Cited by 14 publications

(8 citation statements)

References 32 publications

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“…An elevated risk of asbestosis was also observed for the ECSOD 213Arg/Gly genotype, CAT −262 TT genotype and iNOS LL genotype, but the results were not significant or borderline significant [6–8]. In this paper, we additionally present the interactions between different genotypes, genotypes and smoking, and between genotypes and cumulative asbestos exposure.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Gene-Gene and Gene-Environment Interactions on the Risk of Asbestosis

Franko

Dolžan

Arnerić

et al. 2013

BioMed Research International

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This study investigated the influence of gene-gene and gene-environment interactions on the risk of developing asbestosis. The study comprised 262 cases with asbestosis and 265 controls with no asbestos-related disease previously studied for MnSOD, ECSOD, CAT, GSTT1, GSTM1, GSTP1, and iNOS polymorphisms. Data on cumulative asbestos and smoking were available for all subjects. To assess gene-gene and gene-environmental interactions, logistic regression was used. The associations between MnSOD Ala −9Val polymorphism and the risk of asbestosis and between iNOS genotypes and asbestosis were modified by CAT –262 C > T polymorphism (P = 0.038; P = 0.031). A strong interaction was found between GSTM1-null polymorphism and smoking (P = 0.007), iNOS (CCTTT)n polymorphism and smoking (P = 0.054), and between iNOS (CCTTT)n polymorphism and cumulative asbestos exposure (P = 0.037). The findings of this study suggest that the interactions between different genotypes, genotypes and smoking, and between genotypes and asbestos exposure have an important influence on the development of asbestosis and should be seriously considered in future research on occupational/environmental asbestos-related diseases.

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Section: Discussionmentioning

confidence: 99%

The Influence of Gene-Gene and Gene-Environment Interactions on the Risk of Asbestosis

Franko

Dolžan

Arnerić

et al. 2013

BioMed Research International

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“…We believe that patients with C262C genotype have lower CAT activity, which can cause accumulation of free radicals and oxidative stress. The association between the CAT C262T SNP was found to have an effect on the predisposition to male infertility [39], Shigella flexneri- related infection [40], asbestosis [41], vitiligo [42], and cancer although it remains highly contradictory and inconclusive [43]. …”

Section: Discussionmentioning

confidence: 99%

Analysis of Serum Cytokines and Single-Nucleotide Polymorphisms of SOD1, SOD2, and CAT in Erysipelas Patients

Emene

Кравченко

Айбатова

et al. 2017

Journal of Immunology Research

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Increased free radical production had been documented in group A (β-hemolytic) streptococcus infection cases. Comparing 71 erysipelas patients to 55 age-matched healthy individuals, we sought for CAT, SOD1, and SOD2 single polymorphism mutation (SNPs) interactions with erysipelas' predisposition and serum cytokine levels in the acute and recovery phases of erysipelas infection. Whereas female patients had a higher predisposition to erysipelas, male patients were prone to having a facial localization of the infection. The presence of SOD1 G7958, SOD2 T2734, and CAT C262 alleles was linked to erysipelas' predisposition. T and C alleles of SOD2 T2734C individually were linked to patients with bullous and erythematous erysipelas, respectively. G and A alleles of SOD1 G7958A individually were associated with lower limbs and higher body part localizations of the infection, respectively. Serum levels of IL-1β, CCL11, IL-2Rα, CXCL9, TRAIL, PDGF-BB, and CCL4 were associated with symptoms accompanying the infection, while IL-6, IL-9, IL-10, IL-13, IL-15, IL-17, G-CSF, and VEGF were associated with predisposition and recurrence of erysipelas. While variations of IL-1β, IL-7, IL-8, IL-17, CCL5, and HGF were associated with the SOD2 T2734C SNP, variations of PDFG-BB and CCL2 were associated with the CAT C262T SNP.

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“… 14 Our previous study investigating the association of this polymorphism with asbestosis found a slight increase in the risk of the TT genotype. 16 Superoxide dismutases (SOD) convert superoxide into H 2 O 2 and O 2 . SOD2 is found in mitochondria, where the amount of ROS is very high.…”

Section: Introductionmentioning

confidence: 99%

“… 27 We have previously described the association between SOD2 Ala/Ala genotype and asbestosis 28 as well as association between CAT -262 TT genotype and asbestosis. 16 Landi et al . reported on the association between SOD2 and the risk of MM 25 , but according to our knowledge and available literature, the impact of NQO1 , CAT and hOGG1 polymorphisms on the risk of developing MM has not been studied so far.…”

Section: Introductionmentioning

confidence: 99%

The influence of genetic variability on the risk of developing malignant mesothelioma

Franko

Kotnik

Goričar

et al. 2018

Radiology and Oncology

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BackgroundMalignant mesothelioma is a rare cancer with poor outcome, associated with asbestos exposure. Reactive oxygen species may play an important role in the mechanism of carcinogenesis; therefore, genetic variability in antioxidative defence may modify an individual’s susceptibility to this cancer. This study investigated the influence of functional polymorphisms of NQO1, CAT, SOD2 and hOGG1 genes, gene-gene interactions and gene-environment interactions on malignant mesothelioma risk.Patients and methodsIn total, 150 cases with malignant mesothelioma and 122 controls with no asbestos-related disease were genotyped for NQO1, CAT, SOD2 and hOGG1 polymorphisms.ResultsThe risk of malignant mesothelioma increased with smoking, odds ratio (OR) 9.30 [95% confidence interval (CI): 4.83–17.98] and slightly with age, OR 1.10 (95% CI: 1.08–1.14). Medium and high asbestos exposures represented 7-times higher risk of malignant mesothelioma compared to low exposure, OR 7.05 (95% CI 3.59–13.83). NQO1 rs1800566 was significantly associated with increased malignant mesothelioma risk, OR 1.73 (95% CI 1.02–2.96). Although there was no independent association between either CAT rs1001179 or hOGG1 rs1052133 polymorphism and malignant mesothelioma, interaction between both polymorphisms showed a protective effect, ORint 0.27 (95% CI 0.10–0.77).ConclusionsOur findings suggest a role of both genetic variability in antioxidative defence and repair as well as the impact of gene-gene interactions in the development of malignant mesothelioma. The results of this study could add to our understanding of pathogenesis of malignant mesothelioma and contribute to prevention and earlier diagnosis of this aggressive cancer.

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Asbestosis and Catalase Genetic Polymorphism

Cited by 14 publications

References 32 publications

The Influence of Gene-Gene and Gene-Environment Interactions on the Risk of Asbestosis

The Influence of Gene-Gene and Gene-Environment Interactions on the Risk of Asbestosis

Analysis of Serum Cytokines and Single-Nucleotide Polymorphisms of SOD1, SOD2, and CAT in Erysipelas Patients

The influence of genetic variability on the risk of developing malignant mesothelioma

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