2000
DOI: 10.1159/000030134
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Ascitic Growth of a Spontaneous Transplantable T Cell Lymphoma Induces Thymic Involution

Abstract: We have previously shown that the progressive ascitic growth of a transplantable T cell lymphoma of spontaneous origin in a murine host, designated as Dalton’s lymphoma (DL), induces the inhibition of various immune responses. In a quest to understand the mechanism(s) of tumor-growth-dependent immunosuppression, we were interested to investigate if the thymus, the center for the differentiation of immunocompetent T cells, undergoes any alteration concomitant with the growth of DL. Thus, DL was grown as an asci… Show more

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Cited by 38 publications
(29 citation statements)
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“…4 Moreover, there is evidence for augmented apoptosis of T cells among cancer patients and mice with experimental tumors. 5 Recent evidence from several laboratories, including our own, suggests that tumors may inhibit the development of an effective antitumor immune response either by directly inducing T-cell apoptosis or by sensitizing T lymphocytes to activation-induced cell death.…”
Section: Cd8mentioning
confidence: 99%
See 1 more Smart Citation
“…4 Moreover, there is evidence for augmented apoptosis of T cells among cancer patients and mice with experimental tumors. 5 Recent evidence from several laboratories, including our own, suggests that tumors may inhibit the development of an effective antitumor immune response either by directly inducing T-cell apoptosis or by sensitizing T lymphocytes to activation-induced cell death.…”
Section: Cd8mentioning
confidence: 99%
“…[6][7][8] There is evidence of increased apoptosis among CD8 1 T cells in peripheral blood lymphocytes from cancer patients and animal models. 4 These alterations correlate with the severity of the disease and with poor survival. Thus, tumor-induced immune suppression can add to the spread of the disease and create a barrier to immunotherapeutic interventions.…”
Section: Cd8mentioning
confidence: 99%
“…1 To whom correspondence should be addressed. cellular defense mechanism, and induces thymic atrophy (2,15). Therefore, therapeutic intervention, which can protect the immune system in cancer patients, may enhance the immune competence and increase the survival.…”
Section: Cd8mentioning
confidence: 99%
“…CD8 + CTLs are major effector cells involved in immunologically specific tumor destruction, and CD4 + T cells are essential for ''helping'' CD8 + T celldependent tumor eradication (8). Recently, tumor-induced thymic atrophy is being considered as a part of the immune evasion strategy of the developing tumor (9,10). Because T-cell proliferation, differentiation, and apoptosis take place in thymus, aberration in one or more of these processes due to tumor may therefore result in thymic atrophy.…”
Section: Introductionmentioning
confidence: 99%