2017
DOI: 10.1016/j.dnarep.2017.06.022
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ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress

Abstract: HighlightsASCIZ/ATMIN is not required for ATM activation by replication stress in MEFs.ATM activation is normal in human ASCIZ/ATMIN KO cells.ASCIZ/ATMIN is dispensable for aphidicolin-induced 53BP1 focus formation.

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Cited by 10 publications
(6 citation statements)
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“…We focused on ATMIN because of its relationship with ATM, the nature of which has been context dependent (Liu et al, 2017; Schmidt et al, 2014; Zhang et al, 2014). We used prolonged HU treatment to induce replication stress-dependent double-strand breaks and, hence, ATM signaling.…”
Section: Discussionmentioning
confidence: 99%
“…We focused on ATMIN because of its relationship with ATM, the nature of which has been context dependent (Liu et al, 2017; Schmidt et al, 2014; Zhang et al, 2014). We used prolonged HU treatment to induce replication stress-dependent double-strand breaks and, hence, ATM signaling.…”
Section: Discussionmentioning
confidence: 99%
“…Western blot analysis was performed as described [ 18 ] using antibodies against Actin (EMD Millipore/Merck, MAB1501; loading control), BAK (Sigma, B5897), BAX (WEHI, 49F9-13-3; obtained from David Huang), BCL-2 (Cell Signaling Technology, 50E3) BCL-XL (BD, 610212), BIM (Enzo, 3C5), DYNLL1 (Abcam, ab51603), MCL-1 (Cell Signaling, D35A5), M601 (Abcam, ab110411), tubulin (Sigma, T9026), and XRCC1 (Santa Cruz, sc-11429), horseradish peroxidase-coupled secondary antibodies and ECL reagents (GE Healthcare) antibodies. Western blots were quantified as described [ 60 ]. Subcellular fractionation assays were performed using a cell fractionation kit (Abcam, ab109719).…”
Section: Methodsmentioning
confidence: 99%
“…Up to now, few researches reported the role of ZNF438 and ZNF597 in tumors. ATMIN, also named as ZNF822, functions as a cofactor of ATM and is required for the activation of the ATM signaling pathway (Kanu et al, 2010;Liu et al, 2017). ATM participates in the maintenance of genomic stability and DNA damage repair (Prochazkova et al, 2015;Li et al, 2019) and has been implicated as a tumor suppressor in various cancer types including lung adenocarcinoma (Foster et al, 2019), B-cell lymphoma (Loizou et al, 2011), and colorectal cancer (Li et al, 2021).…”
Section: Discussionmentioning
confidence: 99%