Ascorbic Acid 2-O-.ALPHA.-Glucoside-Induced Redox Modulation in Human Keratinocyte Cell Line, SCC: Mechanisms of Photoprotective Effect against Ultraviolet Light B.

Miyai, Eriko; Yanagida, Mitsuhiro; Akiyama, Junichi; Yamamoto, Ikuo

doi:10.1248/bpb.20.632

Cited by 22 publications

(17 citation statements)

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“…[12][13][14][15]26,39 Recently, several natural antioxidant compounds (lipoic acid, flavonoids, vitamin E, silymarin, anthocyanins, etc) proved to be able to prevent the occurrence and reduce the severity of UV light-induced skin damage. 12,13,[40][41][42] Since the JW-E appeared really effective in all in vitro antioxidant tests employed, including the UV-IP test (which is widely used to investigate the potential photoprotective effectiveness of topical antioxidant agents), 22,23 it was submitted to in vivo experiments. With this aim we assessed the protective effect of a topical gel formulation containing the JW-E against UVB-induced skin erythema in human volunteers, in comparison with that of a gel formulation containing TOC, an antioxidant compound used in cosmetic formulations.…”

Section: Resultsmentioning

confidence: 99%

Chemical analysis and photoprotective effect of an extract of wine from Jacquez grapes

et al. 2002

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The present study was aimed at evaluating the in vitro antioxidant activity and in vivo photoprotective activity of an extract of wine obtained from Jacquez (Vitis aestivalis-cinerea Â V vinifera) grapes (JW-E). The chemical profile of the JW-E was characterised by a significant level of proanthocyanidins, together with lower amounts of anthocyanins and hydroxycinnamic acids. The antioxidant activity of the JW-E was assessed by means of various in vitro tests (bleaching of the stable 1,1-diphenyl-2-picrylhydrazyl radical; peroxidation, induced by the water-soluble radical initiator 2,2'-azobis(2-amidinopropane) hydrochloride, on mixed dipalmitoylphosphatidylcholine/linoleic acid unilamellar vesicles; UV radiation-induced peroxidation in phosphatidylcholine multilamellar vesicles). In all in vitro tests employed, the JW-E proved to possess strong antioxidant/free radicalscavenging effectiveness. Furthermore, when topically applied, a gel formulation containing the JW-E afforded significant in vivo protection against UVB light-induced skin erythema (monitored by reflectance spectrophotometry) in healthy human volunteers.

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Section: Resultsmentioning

confidence: 99%

Chemical analysis and photoprotective effect of an extract of wine from Jacquez grapes

et al. 2002

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“…40 AA therefore not only acts through scavenging reactive oxygen species itself but also potentiates the antioxidant activity of a-tocopherol for protection against free-radical damage. [41][42][43] In fact, topical AA combined with a-tocopherol provided notably increased photoprotection against UV-induced erythema and diminished the number of sunburn cells as compared to that seen for each antioxidant individually 39 which underlines the synergistic effect, particularly in protection against UV-induced oxidative damage. The presence of atocopherol in formulations may also have a stabilizing effect on the photo-degradation of ascorbic acid.…”

Section: Photoprotectionmentioning

confidence: 92%

“…Importantly AA is also capable of recycling photo‐oxidized α‐tocopherol thereby regenerating vitamin E and contributing to an antioxidant reservoir in the skin . AA therefore not only acts through scavenging reactive oxygen species itself but also potentiates the antioxidant activity of α‐tocopherol for protection against free‐radical damage . In fact, topical AA combined with α‐tocopherol provided notably increased photoprotection against UV‐induced erythema and diminished the number of sunburn cells as compared to that seen for each antioxidant individually which underlines the synergistic effect, particularly in protection against UV‐induced oxidative damage.…”

Section: Photoprotectionmentioning

confidence: 93%

“…AA-2G reduced UV-induced damage of human skin keratinocytes and fibroblasts more effectively than ascorbyl 2-phosphate 51 and demonstrated a photoprotective effect against UVB. 41 VC-IP was found to suppress the elevation of intracellular peroxide after UVB irradiation and provide enhanced cellular tolerance against UVB and reactive oxygen species. 27 It also showed antioxidant activity comparable with retinyl palmitate and tocopheryl acetate in an in vitro chemiluminescence assay.…”

Section: Photoprotectionmentioning

confidence: 98%

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Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives

Stamford¹

2012

J of Cosmetic Dermatology

116

132

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Topically applied antioxidants exert their benefits by offering protection from damaging free radicals and over-the-counter cosmeceuticals incorporating antioxidants are among the most popular anti-aging products available. One potent antioxidant of particular note, vitamin C, has been extensively utilized because it possesses a variety of other cutaneous benefits including photoprotection from UV A & B, neocollagenesis, inhibition of melanogenesis and improvement of a variety of inflammatory skin disorders. However, the instability of this water-soluble vitamin, together with difficulties associated with its topical delivery, has presented issues for the formulation chemist. This article reviews the scientific data and clinical studies that underpin the stability, percutaneous absorption, and cutaneous effects of vitamin C together with its commonly utilized, commercially available derivatives.

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“…High levels of AA in the eye lens may suggest that AA contributes to protection of the eye through UV absorption [21]. AA2G is suggested to act in redox modulation as a protective mechanism against UVB [22,23]. Recently, ascorbic acid was found to reduce UV-induced apoptosis through reactivating silenced tumor suppressor genes [24].…”

Section: Introductionmentioning

confidence: 99%

Ascorbic Acid 2-Glucoside Pretreatment Protects Cells from Ionizing Radiation, UVC, and Short Wavelength of UVB

Maeda

Allum

Mussallem

et al. 2020

Genes

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Ascorbic acid 2-glucoside (AA2G), glucosylated ascorbic acid (AA), has superior properties for bioavailability and stability compared to AA. Although AA2G has shown radioprotective properties similar to AA, effects for UV light, especially UVC and UVB, are not studied. AA2G was tested for cytotoxicity and protective effects against ionizing radiation, UVC, and broadband and narrowband UVB in Chinese hamster ovary (CHO) cells and compared to AA and dimethyl sulfoxide (DMSO). Pretreatment with DMSO, AA, and AA2G showed comparative protective effects in CHO wild type and radiosensitive xrs5 cells for cell death against ionizing radiation with reducing the number of radiation-induced DNA damages. Pretreatment with AA and AA2G protected CHO wild type and UV sensitive UV135 cells from UVC and broadband UV, but not from narrowband UVB. DMSO showed no protective effects against tested UV. The UV filtration effects of AA and AA2G were analyzed with a spectrometer and spectroradiometer. AA and AA2G blocked UVC and reduced short wavelengths of UVB, but had no effect on wavelengths above 300 nm. These results suggest that AA2G protects cells from radiation by acting as a radical scavenger to reduce initial DNA damage, as well as protecting cells from certain UVB wavelengths by filtration.

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Ascorbic Acid 2-O-.ALPHA.-Glucoside-Induced Redox Modulation in Human Keratinocyte Cell Line, SCC: Mechanisms of Photoprotective Effect against Ultraviolet Light B.

Cited by 22 publications

References 0 publications

Chemical analysis and photoprotective effect of an extract of wine from Jacquez grapes

Chemical analysis and photoprotective effect of an extract of wine from Jacquez grapes

Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives

Ascorbic Acid 2-Glucoside Pretreatment Protects Cells from Ionizing Radiation, UVC, and Short Wavelength of UVB

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