Ascorbic acid deficiency and premature rupture of fetal membranes

Wideman, Gilder L.; Baird, Glenn H.; Bolding, O. Thomas

doi:10.1016/0002-9378(64)90885-3

Cited by 72 publications

(27 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of this study offer no support to the observation of Wideman et al [3] of a relationship between decreased serum ASA and PROM. However, the data show a trend to a lower ASA concentration in both serum and amniotic fluid in the PROM group.…”

Section: Discussioncontrasting

confidence: 56%

“…Smoking reduces the ASA concentration in maternal serum and cord blood in preg nancy [3], In populations with a high rate of tobacco use and poor nutritional status, the incidence of PROM may be increased. The purpose of this study was to investigate the relationship between the ASA concentration in serum and amniotic fluid and the effect of dietary ASA intake and cigarette use on these two parameters in smoking and non smoking pregnant women.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ascorbic Acid Concentration in Amniotic Fluid in Late Pregnancy

et al. 1991

View full text Add to dashboard Cite

Amniotic fluid and venous blood specimens were obtained from 34 pregnant women and analyzed for the ascorbic acid concentration. The mean amniotic ascorbic acid concentration of smoking pregnant women was less than 50% of that of non-smoking women. Pregnant women who smoked had a significantly lower serum and amniotic fluid ascorbic acid concentration than those who did not smoke. No differences were observed between the groups with or without premature rupture of the fetal membrane. The results suggest that ascorbic acid in the amniotic fluid reflects the ascorbic acid status in the blood of pregnant women and smoking had a greater effect in decreasing the ascorbic acid concentration in amniotic fluid than in serum.

show abstract

Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Ascorbic Acid Concentration in Amniotic Fluid in Late Pregnancy

et al. 1991

View full text Add to dashboard Cite

show abstract

“…Other reports have suggested that an association exists between low plasma AA levels and an increased incidence of spon taneous abortion [19], premature birth and low birth weight [ 18,20].…”

Section: Introductionmentioning

confidence: 99%

Ascorbic Acid Concentrations in Umbilical Cord Veins and Arteries of Preterm and Term Newborns

et al. 1995

View full text Add to dashboard Cite

Ascorbic acid (AA) is a powerful antioxidant required for the defense against oxidative stress. At present it is not known whether AA may play a role in the developmental process of the fetus. We therefore determined the relationship of AA levels between the umbilical cord vein (UCV) and umbilical cord artery (UCA) of preterm (< 37 weeks of gestation) and term (> 37 weeks of gestation) infants and compared those levels to matched maternal venous AA levels. We also assessed the association between UCV plasma AA levels with birth weight and gestational age by measuring AA in 88 UCV plasma samples and 58 UCA plasma samples obtained from newborn infants ranging in gestational age from 24 to 42 weeks and birth weight from 675 to 5,020 g, by high pressure liquid chromatography. Maternal venous samples were collected at the time of delivery. The mean UCV plasma AA levels (mg/dl) were significantly lower in the preterm group than in the term group (0.43 ± 0.59 and 1.16 ± 0.97, respectively; p < 0.002); however, the mean UCA plasma AA levels did not differ between the groups. In contrast, mean maternal venous plasma AA levels of the preterm group (1.33 ± 0.62) were significantly higher than those of the mothers in the term group (0.72 ± 0.69; p < 0.01). A direct correlation was found between UCV levels and birth weight (r = 0.23, p < 0.05), and UCV levels and gestational age (r = 0.23, p < 0.05). We speculate that the preterm gestation, AA may be transported across the placenta in its oxidized form (dehydroascorbic acid) to the fetus, where it is then reduced to AA. The underlying mechanism(s) involved in this process and the clinical significance of these findings need to be elucidated.

show abstract

“…1 In 1964, a relationship between maternal vitamin C status and the occurrence of PROM was first proposed that vitamin C plays an essential role in the synthesis of collagen as well as its stabilization by cross-linking. 21 Hadley et al (1990) have shown that there were lower levels of ascorbic acid (vitamin C) in serum, leucocytes, and amniotic fluid of cases with PPROM as compared to the control group yet it was unsure considering the effect of hemodilution. 22 Matthews et al (2005) showed vitamin C concentration decline as incresing gestational age due to physiologic hemodilution, reduce intake, and increased oxidative stress during pregnancy.…”

Section: Vitamin C and Prommentioning

confidence: 99%

Is vitamin C able to prevent premature rupture of membranes?

Aryanti¹

2016

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Ascorbic acid deficiency and premature rupture of fetal membranes

Cited by 72 publications

References 5 publications

Ascorbic Acid Concentration in Amniotic Fluid in Late Pregnancy

Ascorbic Acid Concentration in Amniotic Fluid in Late Pregnancy

Ascorbic Acid Concentrations in Umbilical Cord Veins and Arteries of Preterm and Term Newborns

Is vitamin C able to prevent premature rupture of membranes?

Contact Info

Product

Resources

About